DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cort and CDC20.1

DIOPT Version :9

Sequence 1:	NP_001260144.1	Gene:	cort / 33937	FlyBaseID:	FBgn0000351	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_195053.1	Gene:	CDC20.1 / 829463	AraportID:	AT4G33270	Length:	457	Species:	Arabidopsis thaliana

Alignment Length:	483	Identity:	105/483 - (21%)
Similarity:	180/483 - (37%)	Gaps:	151/483 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 ERFIPNRFERENIEF-NLKYIGKRKERDILETGVTLTAS---YWRQSGFISNINRTFGIGERRLF 114
            :|||||| ...|.:: :......||.:|  :|....:.|   |.:|.....|:|.|      |:.
plant    35 DRFIPNR-SAMNFDYAHFALTEGRKGKD--QTAAVSSPSKEAYRKQLAETMNLNHT------RIL 90

  Fly   115 QFSSQ-QGTRSRVVDNDSAD-SDWPCNPRARPYAIQNA--THEMPGICSPVDYNMMDWSSGGMVA 175
            .|.:: |.....:..|.||. ...|.:.:.|.|..|.:  |.:.|.|......|::||.|..::|
plant    91 AFRNKPQAPVELLPSNHSASLHQQPKSVKPRRYIPQTSERTLDAPDIVDDFYLNLLDWGSANVLA 155

  Fly   176 MSSGQDVMLWRNLDEST-------MVFSVESP-TSLKYSPDGKHLAIGCMDRNYPVLDLWE---- 228
            ::....|.||   |.||       .:...:.| ||:.::|||:|:|:|.   |...:.||:
plant   156 IALDHTVYLW---DASTGSTSELVTIDEEKGPVTSINWAPDGRHVAVGL---NNSEVQLWDSASN 214

  Fly   229 ---------------------------------------VRSPTEFLVSYRKLFFKSMGY---IS 251
                                                   :|||  .:.:||       |:   :.
plant   215 RQLRTLKGGHQSRVGSLAWNNHILTTGGMDGLIINNDVRIRSP--IVETYR-------GHTQEVC 270

  Fly   252 CIEWSHDGKEVICGTQCGVI------IVLAMPTLNTLMQLREHRHTVKKMKFAPTHKYFASSDTD 310
            .::||..|:::..|....|:      :..:..|...|.:|.||...||.:.:.|
plant   271 GLKWSGSGQQLASGGNDNVVHIWDRSVASSNSTTQWLHRLEEHTSAVKALAWCP----------- 324

  Fly   311 GKIFIFDAVLKVRLLKLDG----RSIVFDWHPWTGEDL-AVAERSPASIFIFNIPRRQFVASYRR 370
                     .:..||...|    |:|.| |:..||..| :|...|.....:::...|:.::|:
plant   325 ---------FQANLLATGGGGGDRTIKF-WNTHTGACLNSVDTGSQVCSLLWSKNERELLSSH-- 377

  Fly   371 RDDRIVIKTLTYSKITGELLVNVIRRDDADLAVCEILVLASLNRVVDLMSHQDRGTLFLMWNPDG 435
                    ..|.:::|                   :....|:.::.:|..|..| .|::..:|||
plant   378 --------GFTQNQLT-------------------LWKYPSMVKMAELTGHTSR-VLYMAQSPDG 414

  Fly   436 TKIATGGLDDTFSLWNFF---PTYKREA 460
            ..:|:...|:|...||.|   .|.|:.|
plant   415 CTVASAAGDETLRFWNVFGVPETAKKAA 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cort	NP_001260144.1	WD40	<166..453	CDD:225201	70/351 (20%)
		WD40	166..451	CDD:295369	68/349 (19%)
		WD40 repeat	201..244	CDD:293791	16/85 (19%)
		WD40 repeat	251..287	CDD:293791	8/41 (20%)
		WD40 repeat	292..326	CDD:293791	4/33 (12%)
		WD40 repeat	334..369	CDD:293791	9/35 (26%)
		WD40 repeat	377..419	CDD:293791	3/41 (7%)
		WD40 repeat	427..466	CDD:293791	13/37 (35%)
CDC20.1	NP_195053.1	WD40	<149..444	CDD:225201	72/360 (20%)
		WD40 repeat	185..222	CDD:293791	11/39 (28%)
		WD40 repeat	229..264	CDD:293791	5/43 (12%)
		WD40 repeat	269..311	CDD:293791	7/41 (17%)
		WD40 repeat	318..356	CDD:293791	12/58 (21%)
		WD40 repeat	361..399	CDD:293791	5/66 (8%)
		WD40 repeat	405..431	CDD:293791	8/25 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19918
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910