Protein Alignment cort and FZR1

DIOPT Version :9

• Sequence 1: NP_001260144.1
• Gene: cort / 33937
• FlyBaseID: FBgn0000351
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: XP_016882352.1
• Gene: FZR1 / 51343
• HGNCID: 24824
• Length: 528
• Species: Homo sapiens
• Alignment Length: 522
• Identity: 118/522 - (22%)
• Similarity: 191/522 - (36%)
• Gaps: 161/522 - (30%)

  Fly    53 GERFIPNR--------FERENIEFNLKYIGKRKERDILETGVTLTASYWRQSGFISNINRTFGIG 109
            |:||||:|        |.|.| |........||.:|..........:|   |..:.  |...|.|
Human    77 GDRFIPSRAGANWSVNFHRIN-ENEKSPSQNRKAKDATSDNGKDGLAY---SALLK--NELLGAG 135

  Fly   110 ----------ERRLFQ--------FSSQQGTRSRVVDNDSADSDWPCNPRAR------------- 143
                      :|||..        |:....|:....|:.:..|.:..:|.:.
Human   136 IEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPT 200

  Fly   144 ------PYAIQNATHEMPGICSPVDYNMMDWSSGGMVAMSSGQDVMLW--------RNLDESTMV 194
                  |:.:.:|    |.:......|::||||..::::..|..|.||        |..|
Human   201 RKISKIPFKVLDA----PELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCD----- 256

  Fly   195 FSVE--SPTSLKYSPDGKHLAIGCMDRNYPVLDLWEVRSPTEFLVSYRKLFFKSM--GY---ISC 252
            .|||  |.||:.:|..|..:|:|   .:...:.:|:.       .:.:||   ||  |:   :..
Human   257 LSVEGDSVTSVGWSERGNLVAVG---THKGFVQIWDA-------AAGKKL---SMLEGHTARVGA 308

  Fly   253 IEWSHDGKEVICGTQCGVIIV--LAMPTLNTLMQLREHRHTVKKMKFAPTHKYFASSDTDGKIFI 315
            :.|  :.:::..|::..:|:.  :..|.|.:..:|:.||..|..:|::..|:..||...|.|:.:
Human   309 LAW--NAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLV 371

  Fly   316 FD--------------AVLKV--------RLLKLDG----RSIVFDWHPWTGEDLAVAERSPASI 354
            ::              |.:|.        .||...|    |.|.| |:..||:.|...
Human   372 WNHSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRF-WNTLTGQPLQCI------- 428

  Fly   355 FIFNIPRRQFVASYRRRDDRIVIKTLTYSKITGELLVNVIRRDDADLAVCEILV--LASLNRVVD 417
                             |....:..|.:||...||:      .....:..:|||  ..||.:|..
Human   429 -----------------DTGSQVCNLAWSKHANELV------STHGYSQNQILVWKYPSLTQVAK 470

  Fly   418 LMSHQDRGTLFLMWNPDGTKIATGGLDDTFSLWNFFPTYKREAILRKQEQKAK-DKCSSLSLYKG 481
            |..|..| .|:|..:|||..|.||..|:|...||.|.        :.:..|.| :..|.|:|:..
Human   471 LTGHSYR-VLYLAMSPDGEAIVTGAGDETLRFWNVFS--------KTRSTKVKWESVSVLNLFTR 526

  Fly   482 IR 483
            ||
Human   527 IR 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cort	NP_001260144.1	WD40	<166..453	CDD:225201	80/331 (24%)
		WD40	166..451	CDD:295369	78/329 (24%)
		WD40 repeat	201..244	CDD:293791	9/42 (21%)
		WD40 repeat	251..287	CDD:293791	6/37 (16%)
		WD40 repeat	292..326	CDD:293791	10/55 (18%)
		WD40 repeat	334..369	CDD:293791	5/34 (15%)
		WD40 repeat	377..419	CDD:293791	11/43 (26%)
		WD40 repeat	427..466	CDD:293791	13/38 (34%)
FZR1	XP_016882352.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810