Protein Alignment cort and Fzr1

DIOPT Version :10

• Sequence 1: NP_523494.1
• Gene: cort / 33937
• FlyBaseID: FBgn0000351
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_001101544.2
• Gene: Fzr1 / 314642
• RGDID: 1308713
• Length: 493
• Species: Rattus norvegicus
• Alignment Length: 519
• Identity: 118/519 - (22%)
• Similarity: 188/519 - (36%)
• Gaps: 158/519 - (30%)

  Fly    53 GERFIPNR--------FERENIEFNLKYIGKRKERDILETGVTLTASYWRQSGFISNINRTFGIG 109
            |:||||:|        |.|.| |........||.:|..........:|   |..:.  |...|.|
  Rat    45 GDRFIPSRAGANWSVNFHRIN-ENEKSPSQNRKAKDATSDNGKDGLAY---SALLK--NELLGAG 103

  Fly   110 ----------ERR----------LFQFSSQQGTRSRVVDND-SADSDWPCNPRAR---------- 143
                      :||          ||.:|......|....|| |..|..|.:.:::
  Rat   104 IEKVQDPQTEDRRLQPSTPEHKGLFTYSLSSKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPT 168

  Fly   144 ------PYAIQNATHEMPGICSPVDYNMMDWSSGGMVAMSSGQDVMLW--------RNLDESTMV 194
                  |:.:.:|    |.:......|::||||..::::..|..|.||        |..|
  Rat   169 RKISKIPFKVLDA----PELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCD----- 224

  Fly   195 FSVE--SPTSLKYSPDGKHLAIGCMDRNYPVLDLWEVRSPTEFLVSYRKLFFKSMGY---ISCIE 254
            .|||  |.||:.:|..|..:|:|   .:...:.:|:..:..:..|        ..|:   :..:.
  Rat   225 LSVEGDSVTSVGWSERGNLVAVG---THKGFVQIWDAAAGKKLSV--------LEGHTARVGALA 278

  Fly   255 WSHDGKEVICGTQCGVIIV--LAMPTLNTLMQLREHRHTVKKMKFAPTHKYFASSDTDGKIFIFD 317
            |:.|  ::..|::..:|:.  :..|.|.:..:|:.||..|..:|::..|:..||...|.|:.:::
  Rat   279 WNAD--QLSSGSRDRMILQRDIRTPALQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWN 341

  Fly   318 --------------AVLKV--------RLLKLDG----RSIVFDWHPWTGEDLAVAERSPASIFI 356
                          |.:|.        .||...|    |.|.| |:..||:.|...
  Rat   342 HSSLSPVQQYTEHLAAVKAIAWSPHQHGLLASGGGTADRCIRF-WNTLTGQPLQCI--------- 396

  Fly   357 FNIPRRQFVASYRRRDDRIVIKTLTYSKITGELLVNVIRRDDADLAVCEILV--LASLNRVVDLM 419
                           |....:..|.:||...||:      .....:..:|||  ..||.:|..|.
  Rat   397 ---------------DTGSQVCNLAWSKHANELV------STHGYSQNQILVWKYPSLTQVAKLT 440

  Fly   420 SHQDRGTLFLMWNPDGTKIATGGLDDTFSLWNFFPTYKREAILRKQEQKAKDKCSSLSLYKGIR 483
            .|..| .|:|..:|||..|.||..|:|...||.|          .:.:..|:..|.|:|:..||
  Rat   441 GHSYR-VLYLAMSPDGEAIVTGAGDETLRFWNVF----------SKTRSTKESVSVLNLFTRIR 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cort	NP_523494.1	WD40	<168..451	CDD:441893	75/325 (23%)
		WD40 repeat	201..244	CDD:293791	8/42 (19%)
		WD40 repeat	251..287	CDD:293791	7/37 (19%)
		WD40 repeat	292..326	CDD:293791	10/55 (18%)
		WD40 repeat	334..369	CDD:293791	5/34 (15%)
		WD40 repeat	377..419	CDD:293791	11/43 (26%)
		WD40 repeat	427..466	CDD:293791	13/38 (34%)
Fzr1	NP_001101544.2	WD40	<200..472	CDD:441893	73/321 (23%)
		WD40 repeat	232..269	CDD:293791	8/47 (17%)
		WD40 repeat	275..311	CDD:293791	7/37 (19%)
		WD40 repeat	316..352	CDD:293791	7/35 (20%)
		WD40 repeat	359..397	CDD:293791	11/62 (18%)
		WD40 repeat	402..440	CDD:293791	11/43 (26%)
		WD40 repeat	446..487	CDD:293791	15/50 (30%)