DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cort and slp1

DIOPT Version :9

Sequence 1:	NP_001260144.1	Gene:	cort / 33937	FlyBaseID:	FBgn0000351	Length:	483	Species:	Drosophila melanogaster
Sequence 2:	NP_593161.1	Gene:	slp1 / 2543222	PomBaseID:	SPAC821.08c	Length:	488	Species:	Schizosaccharomyces pombe

Alignment Length:	505	Identity:	98/505 - (19%)
Similarity:	170/505 - (33%)	Gaps:	169/505 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VCDSPNKNSKLDKKSLTPFKKVRRKNWKQEAAYKSDTSKGQEVSYVGERFIPNRFERENIEFNLK 71
            :|.||...|:                    .|.:||            ||||:|....|
pombe    73 LCGSPRNKSR--------------------PASRSD------------RFIPSRPNTAN------ 99

  Fly    72 YIGKRKERDILETGVTLTASYWRQSGFISNINR--TFGIGERRLFQFSSQQGTRSRVVDNDSADS 134
                                     .|:::|:.  .|...|...........||......|:.::
pombe   100 -------------------------AFVNSISSDVPFDYSESVAEACGFDLNTRVLAFKLDAPEA 139

  Fly   135 DWPCNPRA------RPYAIQ-----NATHE----MPGICSPVDYNMMDWSSGGMVAMSSGQDVML 184
            ..|.:.|.      ||....     |.|.|    .|||......|::|||:..:||::..::|.:
pombe   140 KKPVDLRTQHNRPQRPVVTPAKRRFNTTPERVLDAPGIIDDYYLNLLDWSNLNVVAVALERNVYV 204

  Fly   185 WR----------NLDESTMVFSVESPTSLKYSPDGKHLAIGCMDRNYPVLDLWEVRSPTEFLVSY 239
            |.          ..||||.|.||      |:|.||..|::|.   ...::|:::|.|.|:.
pombe   205 WNADSGSVSALAETDESTYVASV------KWSHDGSFLSVGL---GNGLVDIYDVESQTKL---- 256

  Fly   240 RKLFFKSMGYISCIEWSHDGKEVI-CGTQCGVI----IVLAMPTLNTLMQLREHRHTVKKMKFAP 299
             :........:.|:.|:   :.|: .|::.|.|    :.:|...:.|   |:.|...|..:.:..
pombe   257 -RTMAGHQARVGCLSWN---RHVLSSGSRSGAIHHHDVRIANHQIGT---LQGHSSEVCGLAWRS 314

  Fly   300 THKYFASSDTDGKIFIFDAVLKV-RLLKLDGRSIV--FDWHPWTGEDLA---------------- 345
            .....||...|..:.|:||...: :..|.:..:.|  ..|.||....||
pombe   315 DGLQLASGGNDNVVQIWDARSSIPKFTKTNHNAAVKAVAWCPWQSNLLATGGGTMDKQIHFWNAA 379

  Fly   346 -------VAERSPASIFIFNIPRRQFVASYRRRDDRIVIKTLTYSKITGELLVNVIRRDDADLAV 403
                   |...|..:..|::...::.::::...|:.:.|  .:||.
pombe   380 TGARVNTVDAGSQVTSLIWSPHSKEIMSTHGFPDNNLSI--WSYSS------------------- 423

  Fly   404 CEILVLASLNRVVDLMSHQDRGTLFLMWNPDGTKIATGGLDDTFSLWNFF 453
                  :.|.:.||:.:|..| .|:...:|||..::|...|:....|..:
pombe   424 ------SGLTKQVDIPAHDTR-VLYSALSPDGRILSTAASDENLKFWRVY 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cort	NP_001260144.1	WD40	<166..453	CDD:225201	67/327 (20%)
		WD40	166..451	CDD:295369	66/325 (20%)
		WD40 repeat	201..244	CDD:293791	10/42 (24%)
		WD40 repeat	251..287	CDD:293791	9/40 (23%)
		WD40 repeat	292..326	CDD:293791	7/34 (21%)
		WD40 repeat	334..369	CDD:293791	8/57 (14%)
		WD40 repeat	377..419	CDD:293791	6/41 (15%)
		WD40 repeat	427..466	CDD:293791	7/27 (26%)
slp1	NP_593161.1	WD40	<164..487	CDD:225201	74/351 (21%)
		WD40	202..464	CDD:295369	61/309 (20%)
		WD40 repeat	225..261	CDD:293791	12/49 (24%)
		WD40 repeat	266..301	CDD:293791	8/40 (20%)
		WD40 repeat	309..343	CDD:293791	6/33 (18%)
		WD40 repeat	349..388	CDD:293791	6/38 (16%)
		WD40 repeat	393..433	CDD:293791	8/66 (12%)
		WD40 repeat	439..463	CDD:293791	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0305
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19918
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910