Protein Alignment cort and fzr-1

DIOPT Version :10

• Sequence 1: NP_523494.1
• Gene: cort / 33937
• FlyBaseID: FBgn0000351
• Length: 483
• Species: Drosophila melanogaster
• Sequence 2: NP_001382697.1
• Gene: fzr-1 / 174516
• WormBaseID: WBGene00001510
• Length: 704
• Species: Caenorhabditis elegans
• Alignment Length: 480
• Identity: 97/480 - (20%)
• Similarity: 155/480 - (32%)
• Gaps: 183/480 - (38%)

  Fly    70 LKYIGKRKERDILETGVTLTASYWRQSGFISNINRTFGIGERRLFQFSSQQGTRSRVVDNDSADS 134
            :||.|:          .|.||:        |.....||:..:||.:
 Worm   342 VKYGGQ----------ATTTAT--------SPFGGPFGVDSQRLLR------------------- 369

  Fly   135 DWPCNPR-------ARPYAIQNATHEMPGICSPVDYNMMDWSSGGMVAMSSGQDVMLWR------ 186
                .||       ..||.:.:|    |.:......|::||||...:::.....|.||.
 Worm   370 ----TPRKPIRKVPKNPYKVLDA----PELQDDFYLNLVDWSSQNQLSVGLAACVYLWSATTSQV 426

  Fly   187 -NLDESTMVFSVESPTSLKYSPDGKHLAIGCMDRNYPVLDLWEV--RSPTEFLVSYRKLFFKSMG 248
             .|.:.......:..||:::...|..||:|   .:..|..:|:|  :..|..|..:       ..
 Worm   427 IKLCDLGQTNEQDQVTSVQWCDKGDLLAVG---TSRGVTQIWDVTTQKKTRELTGH-------SS 481

  Fly   249 YISCIEWSHDGKEVIC-GTQCGVIIVLAMPTLNTLM--QLREHRHTVKKMKFAPTHKYFASSDTD 310
            .:.|:.|:.|   .|| |::...|:...:...:..|  :|..||..|..:|::|..:..||...|
 Worm   482 RVGCLAWNAD---TICSGSRDRTIMHRDIRCDDNDMGRKLTNHRQEVCGLKWSPDKQLLASGGND 543

  Fly   311 GKIFIFDAVLKVRLLKLDGRSIVFDWHPWTGEDLAVAERSPASIFIFNIPRRQFVASYRRRDDRI 375
            .::.:                       |                  |:.|.:.:.:|.:.:  .
 Worm   544 NQLLV-----------------------W------------------NLRRNEPIQTYTQHN--A 565

  Fly   376 VIKTLTYSKITGELLV-------------NVIRRD-----DADLAVCEI--------LV------ 408
            .:|.|.:|.....|||             |.:...     |....||.:        ||
 Worm   566 AVKALAWSPHHHGLLVSGGGTADRCLRFWNTLTAQPMQCVDTGSQVCNVAWSKHSSELVSTHGYS 630

  Fly   409 ----------LASLNRVVDLMSHQDRGTLFLMWNPDGTKIATGGLDDTFSLWNFF-----PTYKR 458
                      ..||..|..|:.||.| .|:|..:|||..|.||..|:|...|:.|     ||..|
 Worm   631 FNHLQVIIWKYPSLQPVTKLVGHQYR-VLYLAMSPDGESIVTGAGDETLRFWHVFNKGNPPTITR 694

  Fly   459 EAILRKQEQKAKDKCSSLSLYKGIR 483
                           |.|:|:..||
 Worm   695 ---------------SKLNLHSTIR 704

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cort	NP_523494.1	WD40	<168..451	CDD:441893	68/336 (20%)
		WD40 repeat	201..244	CDD:293791	11/44 (25%)
		WD40 repeat	251..287	CDD:293791	9/38 (24%)
		WD40 repeat	292..326	CDD:293791	6/33 (18%)
		WD40 repeat	334..369	CDD:293791	3/34 (9%)
		WD40 repeat	377..419	CDD:293791	15/83 (18%)
		WD40 repeat	427..466	CDD:293791	15/43 (35%)
fzr-1	NP_001382697.1	WD40	348..693	CDD:441893	88/436 (20%)
		WD40 repeat	441..478	CDD:293791	11/39 (28%)
		WD40 repeat	484..520	CDD:293791	9/38 (24%)
		WD40 repeat	525..561	CDD:293791	9/76 (12%)
		WD40 repeat	568..606	CDD:293791	7/37 (19%)
		WD40 repeat	611..651	CDD:293791	7/39 (18%)