DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cort and CDC20B

DIOPT Version :10

Sequence 1:NP_523494.1 Gene:cort / 33937 FlyBaseID:FBgn0000351 Length:483 Species:Drosophila melanogaster
Sequence 2:NP_001163873.1 Gene:CDC20B / 166979 HGNCID:24222 Length:519 Species:Homo sapiens


Alignment Length:507 Identity:102/507 - (20%)
Similarity:193/507 - (38%) Gaps:150/507 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    33 WKQE--AAYKSDT-SKGQEVSYVGE---RFIPNRFERENIEFNLKYIGKRKERDILET---GVTL 88
            |:|.  .|..||: .:.|..:|:.|   ..:....|:|.:.     :|.|||:  |:|   |::.
Human    77 WQQSQTRALSSDSFGEEQSTTYLPEASGSVLKTPPEKETLT-----LGSRKEQ--LKTPSKGISE 134

  Fly    89 TASY--------------WRQSGFISNINRTFGIGERRLFQ-FSSQ---QGTRSRVVDNDSADSD 135
            |::.              |::|        ....|::.|.| |.:|   |....::...:.::..
Human   135 TSNSALHFCKAPHAMDRDWKES--------VASKGQKCLKQLFVTQNVVQQANGKMQLCEQSECV 191

  Fly   136 WP-CNP--RARPYAIQNATHEMPGICSPV----------DY--NMMDWSSGGMVAMSSGQDVMLW 185
            |. |..  |...:.::::......|..|.          ||  |::|||...:||::.|..|.:|
Human   192 WKGCKDGVRDESFHLKSSGDINDSILQPEVKIHITGLRNDYYLNILDWSFQNLVAIALGSAVYIW 256

  Fly   186 --------RNLDESTMVFSVESPTSLKYSPDGKHLAIGCMDRNYPVLDLWEVRSPTEFLVSYRKL 242
                    .|:|.|.....:.|.:.:|   :|..||:|..:..   :.||:|.:        :|.
Human   257 NGENHNGIENIDLSLTCNYISSVSWIK---EGTCLAVGTSEGE---VQLWDVVT--------KKR 307

  Fly   243 FFKSMGYIS---CIEWSHDGKEVICGTQCGVI----IVLAMPTLNTLMQLREHRHTVKKMKFAPT 300
            ....:|::|   .:.|:|  ..:..|::.|.:    :.:|...:.||    .|:..|..:|::|.
Human   308 LRNMLGHLSVVGALSWNH--FILSSGSRLGRVYHHDVRVAQHHVGTL----RHKQAVCALKWSPD 366

  Fly   301 HKYFASSDTDGKIFIF----DAVLKVRLLKLDGRSI---VFDWHPWTGEDLAVAERSPASIFIFN 358
            .:..:|..:||.:.|:    .|..:.:.||:..:|.   ..||.||....||:..          
Human   367 GRLLSSGCSDGLLTIWPHDPGASAQGQPLKVITQSTAVKAMDWCPWQSGVLAIGG---------- 421

  Fly   359 IPRRQFVASYRRRDDRIVIKTLTYSKITGELLVNVIRRDDADLAVCEILVL-------------- 409
                      ..:|.|:.|..:...|        .|:....:..:|.::.|              
Human   422 ----------GMKDGRLHILDINAGK--------SIQTPSTNSQICSLIWLPKTKEIATGQGTPK 468

  Fly   410 --------ASLNRVVDLMSHQDRGTLFLMWNPDGTKIATGGLDDTFSLWNFF 453
                    .:::|......|:.| .|.|..:||.|::.:...|.|.|:||.:
Human   469 NDVTVWTCPTVSRSGGFFGHRGR-VLHLSLSPDQTRVFSAAADGTASVWNCY 519

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cortNP_523494.1 WD40 <168..451 CDD:441893 65/326 (20%)
WD40 repeat 201..244 CDD:293791 9/42 (21%)
WD40 repeat 251..287 CDD:293791 8/42 (19%)
WD40 repeat 292..326 CDD:293791 8/37 (22%)
WD40 repeat 334..369 CDD:293791 6/34 (18%)
WD40 repeat 377..419 CDD:293791 6/63 (10%)
WD40 repeat 427..466 CDD:293791 10/27 (37%)
CDC20BNP_001163873.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 79..133 16/60 (27%)
WD 1 229..266 11/36 (31%)
WD40 repeat 235..271 CDD:293791 11/35 (31%)
WD 2 271..310 10/52 (19%)
WD40 <274..517 CDD:441893 55/291 (19%)
WD40 repeat 276..313 CDD:293791 10/50 (20%)
WD 3 311..341 6/31 (19%)
WD40 repeat 319..350 CDD:293791 5/32 (16%)
WD 4 353..392 9/38 (24%)
WD40 repeat 358..399 CDD:293791 10/40 (25%)
WD 5 399..441 12/69 (17%)
WD40 repeat 405..443 CDD:293791 11/65 (17%)
WD 6 443..484 3/40 (8%)
WD40 repeat 448..486 CDD:293791 3/37 (8%)
WD 7 487..519 12/32 (38%)

Return to query results.
Submit another query.