DRSC/TRiP Functional Genomics Resources

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Protein Alignment cort and Cdc20

DIOPT Version :10

Sequence 1:NP_523494.1 Gene:cort / 33937 FlyBaseID:FBgn0000351 Length:483 Species:Drosophila melanogaster
Sequence 2:NP_075712.2 Gene:Cdc20 / 107995 MGIID:1859866 Length:499 Species:Mus musculus


Alignment Length:547 Identity:119/547 - (21%)
Similarity:206/547 - (37%) Gaps:136/547 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 DSPNKNS------KLDKKSLTPF-KKVRRKNWKQEAAYKSDTSKGQEVSYV--------GERFIP 58
            |:|..|:      :..|::..|. ..:|..|....|......:.|:..|.|        |:||||
Mouse    17 DAPIPNAPVARWQRKAKEATGPAPSPMRAANRSHSAGRTPGRTPGKSSSKVQTTPSKPGGDRFIP 81

  Fly    59 NR--FERENIEFNLKYIGKRKERDILETGVTLTASYWRQSGFISNINRTFGIGERRLFQFSSQ-- 119
            .|  .:.|...|.|.     ||....:.|......:  |..:..|:| .|.:.|.::.:.|.:  
Mouse    82 QRSASQMEVASFLLS-----KENQPEDRGTPTKKEH--QKAWSLNLN-GFDVEEAKILRLSGKPQ 138

  Fly   120 ---QGTRSRVVDNDSADSDWPCNPRARPYAIQNATHEMPGICSPV--------DY--NMMDWSSG 171
               :|.::|:....|        .:|.|.:.:.....:|.:...:        ||  |::|||||
Mouse   139 NAPEGYQNRLKVLYS--------QKATPGSSRKTCRYIPSLPDRILDAPEIRNDYYLNLVDWSSG 195

  Fly   172 GMVAMSSGQDVMLWR-NLDESTMVFSVESP----TSLKYSPDGKHLAIGCMDRNYPVLDLWEVRS 231
            .::|::....|.||. ...:...:..:|.|    :|:.:..:|.:||:|..:..   :.||:|:.
Mouse   196 NVLAVALDNSVYLWNAGSGDILQLLQMEQPGDYISSVAWIKEGNYLAVGTSNAE---VQLWDVQQ 257

  Fly   232 PTEFLVSYRKLFFKSMGYISCIEWSHDGKEVICGTQCGVI----IVLAMPTLNTLMQLREHRHTV 292
            ....    |.:...| ..:|.:.|  :...:..|::.|.|    :.:|...:.|   |..|...|
Mouse   258 QKRL----RNMTSHS-ARVSSLSW--NSYILSSGSRSGHIHHHDVRVAEHHVAT---LSGHSQEV 312

  Fly   293 KKMKFAPTHKYFASSDTDGKIFIFD--------AVLKVRLLKLDGRSIVFDWHPWTGEDLAV-AE 348
            ..:::||..::.||...|..:.::.        |.|:. ..:..|......|.||....||. ..
Mouse   313 CGLRWAPDGRHLASGGNDNIVNVWPSGPGESGWAPLQT-FTQHQGAVKAVAWCPWQSNILATGGG 376

  Fly   349 RSPASIFIFNIPRRQFVASYRRRDDRIVIKTLTYSKITGELLVNVIRRDDADLAVCEIL------ 407
            .|...|.|:|:                         .:|..|..|    |....||.||      
Mouse   377 TSDRHIRIWNV-------------------------CSGACLSAV----DVHSQVCSILWSPHYK 412

  Fly   408 ----------------VLASLNRVVDLMSHQDRGTLFLMWNPDGTKIATGGLDDTFSLWNFFPTY 456
                            ...::.:|.:|..|..| .|.|..:|||..:|:...|:|..||..|   
Mouse   413 ELISGHGFAQNQLVIWKYPTMAKVAELKGHTAR-VLGLTMSPDGATVASAAADETLRLWRCF--- 473

  Fly   457 KREAILRKQEQKAKDKCSSLSLYKGIR 483
            :.:..||::.:||....||| :::|||
Mouse   474 EMDPALRREREKASVAKSSL-IHQGIR 499

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cortNP_523494.1 WD40 <168..451 CDD:441893 68/322 (21%)
WD40 repeat 201..244 CDD:293791 9/42 (21%)
WD40 repeat 251..287 CDD:293791 8/39 (21%)
WD40 repeat 292..326 CDD:293791 8/41 (20%)
WD40 repeat 334..369 CDD:293791 9/35 (26%)
WD40 repeat 377..419 CDD:293791 9/63 (14%)
WD40 repeat 427..466 CDD:293791 13/38 (34%)
Cdc20NP_075712.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 27..82 12/54 (22%)
WD 1 182..221 12/38 (32%)
WD40 repeat 188..224 CDD:293791 10/35 (29%)
WD40 <190..471 CDD:441893 69/324 (21%)
WD 2 224..263 9/45 (20%)
WD40 repeat 229..266 CDD:293791 9/43 (21%)
WD 3 266..303 7/39 (18%)
WD40 repeat 272..307 CDD:293791 8/39 (21%)
WD 4 307..346 7/38 (18%)
WD40 repeat 312..352 CDD:293791 8/40 (20%)
WD 5 353..395 12/66 (18%)
WD40 repeat 359..397 CDD:293791 12/66 (18%)
WD 6 397..438 6/40 (15%)
WD40 repeat 402..440 CDD:293791 5/37 (14%)
WD 7 441..480 13/42 (31%)

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