DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cup and Eif4enif1

DIOPT Version :9

Sequence 1:	NP_001285687.1	Gene:	cup / 33934	FlyBaseID:	FBgn0000392	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_001160019.1	Gene:	Eif4enif1 / 74203	MGIID:	1921453	Length:	983	Species:	Mus musculus

Alignment Length:	755	Identity:	161/755 - (21%)
Similarity:	272/755 - (36%)	Gaps:	225/755 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   404 AFFKNK-----NKPNLISDESIIQSQPPQPQTEFQDPAIVNQRRIGSGRLNHSKWGYNDEDYHSY 463
            ||.:.|     ..|:..:.|.::..: .:|.:: |.|:.::::....|..:..||      :.|.
Mouse    13 AFLELKKLPTSKSPHRYTKEELLDIK-ERPYSK-QRPSCLSEKYDSDGVWDPEKW------HASL 69

  Fly   464 H--NGKSQHMEEV--NSKNSKNMTVLQFFDNGE--------ISSQPQRRPNTPVMGMSINRSEND 516
            :  :|:|..:|.:  .|::.:...|.:..|..|        :...||||.    .|...:.:.
Mouse    70 YPASGRSSPVESLKKESESDRPSLVRRIADPRERVKEDDLDVVLSPQRRS----FGGGCHVTA-- 128

  Fly   517 TLHSNESSEDLSRANENY----VKRVMSGFLVVS-------------------KPKSRDVEDRHH 558
            .:.|..|...|.:.::..    .:|:.||.::.:                   :.:.||.:|:..
Mouse   129 AVSSRRSGSPLEKDSDGLRLLGGRRIGSGRIISARAFEKDHRLSDKDLRDLRDRDRERDYKDKRF 193

  Fly   559 R------------RYRNQN---EEPEWFSCGPTSRLDTIELCGFDEDEEKMLKEGNKNHGLGETE 608
            |            |.||.:   |||||||.||||:.:||||.|||   :|:|:|.:|  |...|.
Mouse   194 RREFGDSKRVFGERRRNDSYTEEEPEWFSAGPTSQSETIELTGFD---DKILEEDHK--GRKRTR 253

  Fly   609 RETSKQKMDHKYKWTHAEPMGRSKYMPKHDTNNNHNV---ENMNNVMATEHQQQKE--------E 662
            |.|:..|                    :.....|..|   :.:..::|.|....:|        |
Mouse   254 RRTASVK--------------------EGIVECNGGVAEEDEVEVILAQEPSADQEVPRDVILPE 298

  Fly   663 KRPGSGRSFQFDKFNQSQQNYESSSYVNHQQPPQTQPQQMQQQSNTNTNNSKFMSFFAN--EGNS 725
            :.||     :|| ||:         :.|..:.|.............:.:.|:|..:|:|  ...|
Mouse   299 QSPG-----EFD-FNE---------FFNLDKVPCLASMIEDVLGEGSVSASRFSRWFSNPSRSGS 348

  Fly   726 SSSSLNEF----------FKQAI---NQGHGNNPEQPKSLGHIGQMPSVDQLEAKWRRNSLNNVG 777
            .||||...          .:||:   .|..||         :...:||.|..|.|      .::.
Mouse   349 RSSSLGSTPHEELERLAGLEQAVLSPGQNSGN---------YFAPIPSEDHAENK------VDIL 398

  Fly   778 ETANKQTDNFQKLIGSLSSAKPQSQAVGYDAISNFIMQQQQYQ--------QQQQK-------QH 827
            |...|...:.:.|:.|||:.|.:.:...:   |..::..::.:        .||.|       :|
Mouse   399 EMLQKAKVDLKPLLSSLSANKEKLKESSH---SGVVLSVEEVEAGLKGLKVDQQMKNSTPFMAEH 460

  Fly   828 L-----------IIQQQQQHTAFLASLQLKAILGRADTQLLLLR------LTKGEI-----SKHG 870
            |           .:::....|||...:......|...||..:.|      |...||     ||:.
Mouse   461 LEETLSAASSNRQLKKDGDMTAFNKLVNTMKASGTLPTQPKVSRNVESHLLAPAEIPGQPVSKNI 525

  Fly   871 LLVQLANPRLTDMDREA-------ITAVLQFTNTQQQQQQHKQQLDMLSSTVIASQLQNLHNL-- 926
            |...|..|    :.|.|       :...|:.|.:...|:.....:..:..|..|| ...||..
Mouse   526 LQELLGQP----VQRPASSNLLSGLMGSLEATASLLSQRAPSPPMSQVFRTQAAS-ADYLHPRIP 585

  Fly   927 ------AIVQQTLAARQQPQHNPQTQAPHQLSQEDLQAHANVIMRNAVMKRKIEEQTSKLINGG- 984
                  :..||.|....|....|.:....|:||.:||..|   :....:...:..||:.....|
Mouse   586 SPIGFPSGPQQLLGDPFQGMRKPMSPVSAQMSQLELQQAA---LEGLALPHDLAVQTAPFYQPGF 647

  Fly   985 AKHQAQ--QQYLNRGQQRQARPDANSNALLHALISGGGNN 1022
            :|.|..  :..|...|||.::    |.|.:|     |||:
Mouse   648 SKPQVDRTRDGLRNRQQRMSK----SPAPMH-----GGNS 678

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cup	NP_001285687.1	DUF2477	227..>305	CDD:287586
Eif4enif1	NP_001160019.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		3/8 (38%)
		EIF4E-T	29..710	CDD:371079	157/739 (21%)
		YXXXXLphi motif. /evidence=ECO:0000269\|PubMed:16343815	29..35		1/5 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..99		12/65 (18%)
		Interaction with CSDE1. /evidence=ECO:0000250\|UniProtKB:Q9NRA8	130..160		6/29 (21%)
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q9NRA8	194..210		2/15 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..229		14/22 (64%)
		Interaction with DDX6. /evidence=ECO:0000250\|UniProtKB:Q9NRA8	218..239		16/23 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..360		6/18 (33%)
		Nuclear export signal. /evidence=ECO:0000250\|UniProtKB:Q9NRA8	437..446		0/8 (0%)
		Interaction with LSM14A. /evidence=ECO:0000250\|UniProtKB:Q9NRA8	447..489		8/41 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	585..616		5/30 (17%)
		Nuclear export signal. /evidence=ECO:0000250\|UniProtKB:Q9NRA8	612..637		6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	642..693		13/46 (28%)
		Interaction with PATL1. /evidence=ECO:0000250\|UniProtKB:Q9NRA8	694..712
		Atrophin-1	707..>934	CDD:367360
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..800
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	906..951
		Interaction with LSM14A. /evidence=ECO:0000250\|UniProtKB:Q9NRA8	938..983
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847835
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006297
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12269
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.030