Protein Alignment cup and LOC5666753

DIOPT Version :10

• Sequence 1: NP_523493.3
• Gene: cup / 33934
• FlyBaseID: FBgn0000392
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: XP_001688305.3
• Gene: LOC5666753 / 5666753
• VectorBaseID: AGAMI1_008451
• Length: 2106
• Species: Anopheles gambiae
• Alignment Length: 1285
• Identity: 244/1285 - (18%)
• Similarity: 400/1285 - (31%)
• Gaps: 465/1285 - (36%)

  Fly     5 EAEQENGAGALKIATNAGATDRPAHQQLPLPVEDQQDEVLTPAEKGKFE--------------YP 55
            :::...|.|.   |.:.|.|..|.:.    |..:||...:.....|...              :|
Mosquito  1003 QSDLNGGEGG---APSGGRTPGPPND----PFAEQQPMAIGGGGGGSIPRLIMPGNDPAIGAIHP 1060

  Fly    56 P----PP----PPPTP------VQAPLATKATALNASQEHDDDEANSEKWEDPCAPPPPPPLP-- 104
            |    ||    ||.||      .|..||.| ..||...|:..:....       .|||..|.|
Mosquito  1061 PVVAAPPAGGAPPTTPDGGAVRQQELLAFK-KLLNQMSENQMNGGGG-------GPPPHQPGPPV 1117

  Fly   105 ------------TSAFLATGLGYLKLPAFKLKDALEKAITKLEANKRTLKASPESSRSIKNKNVV 157
                        .:|..|...|....|..:     ..|::.|.|..:.:..:|........::
Mosquito  1118 QQHHGHPAHAAHMAAVAAQHQGGQGPPPHQ-----GAAMSALPAMLQMMHMAPMPHPGTDQRH-- 1175

  Fly   158 ALEMLPRRSNPET------IGDGSM--------LASTSTAVMLQTKKPAVIVEMERRCKII--NL 206
            |.|:|.|   |||      :..|.:        |.:.:||...:....||:.......:::  :|
Mosquito  1176 ATELLKR---PETQTLMMAVARGEVSQHSLWQQLTNPATAQSHREIISAVLGACNGGSRVVSPSL 1237

  Fly   207 LAKQNQILESI------------SGEAIPMHGPSKHLHED---EGLTLQVLSARASTPYTQPSSM 256
            |...|.|...:            :|..:..| |.:.:...   .|:..::.|.|....:||  |:
Mosquito  1238 LLNPNSIQPPMPMPIPPPAAPAGAGANLLFH-PKQQVRLSPLPNGMPQRIPSPRELQYHTQ--SI 1299

  Fly   257 LSCTAVSCDLE--------------HDSPRKQVASKEAVPEQQSSQVQQKRPPSTGIHKPGSLRA 307
            |....:...||              ....::|....:...:||..|.||::.||.  .:|.|.:.
Mosquito  1300 LQNALIRKKLEEQRENYRKRQEQQQQQQQQQQQQQHQQQQQQQQQQQQQQQQPSQ--PQPASQQQ 1362

  Fly   308 PKAVRPTTAPVVSSKPVKSYTRSRLMDIRNGMFNALMHRSKESFVMPRIATCDDIELEGRLRRMN 372
            |:.......|....:.:|...:            .:||:..
Mosquito  1363 PQPPEQPGQPEELQQKLKEQQQ------------PMMHQGP------------------------ 1391

  Fly   373 IWRTSDGTRFRTRSTTANLNMNNNNNNECMPAFFKNKNKPNLISDESIIQSQPPQPQTEFQDPAI 437
                                          ||....:|.|:|           |..|:| ||.|.
Mosquito  1392 ------------------------------PAAQSMQNFPHL-----------PPAQSE-QDAAP 1414

  Fly   438 VNQRRIGSGRLNHSKWGYNDEDYHSYHNGKSQHMEEVNSKNSKNMTVLQFFDNGEISSQP--QRR 500
            ..|.       :.|....:.|..|:.|:....|.                      |:||  |:.
Mosquito  1415 QQQH-------HQSAAEPSQEPRHAQHSDAPDHQ----------------------SAQPTGQQP 1450

  Fly   501 PNTPVMG------------------------------------MSINRSENDTLHSNE--SSEDL 527
            .|...||                                    .:::.|:.:.:.:.:  |...|
Mosquito  1451 ANPAEMGPAAAAAAVPGGTSMIKAGGGGPVGGGRIISGGAAASAAVSPSKQNQMQTQQVASPTPL 1515

  Fly   528 SRANENYVKRVMSGFLVVSKPKSRDVEDRHHRRYRNQNEE--PEWFSCGPTSRLDTIEL------ 584
            :....:.:::     :..::.|..|....||.:.:.|.::  |:....||..: ..:.|
Mosquito  1516 AFTPTSVLRK-----MTAAQEKEPDSAIPHHMQQQQQQQQLPPQQQQQGPMPQ-PQLPLPPAHPQ 1574

  Fly   585 CGFDEDEEKMLKEGNKNH------GLGET-------ERETSKQKMDHKYKWTHAEPMGRSKYMPK 636
            ...:|.:::..::|:..|      ||..:       .::..||:|..:.: .|.:|.....:.|:
Mosquito  1575 MMLNEQQQQQQQQGHLPHVEPGRMGLNYSALLEMMQHQQYMKQQMQQQMQ-QHQKPFPLHPHGPQ 1638

  Fly   637 HDTNNNHNVENMNNVMATEHQQQKEEKRPGSGRSFQFDKFNQSQQNYESSSYVNHQQPPQTQPQQ 701
            |..  .|.:...........|||::::.|...:..||..               ..||||::.||
Mosquito  1639 HPV--MHPMPGGPQPPQPPPQQQQQQQPPQPSQPGQFPA---------------ESQPPQSEQQQ 1686

  Fly   702 MQQQSNTNTNNSKFMSFFANEGNSSSSSLNEFFKQAINQGHGNNPEQPKSLGHIGQMPS-----V 761
            .||:.          |.|...|......:|.........|..:.|..|..:..:|.|||     :
Mosquito  1687 QQQRP----------SPFGQPGPHPPPPMNMMHHHGPGVGANHLPVVPAIINPMGSMPSSVVGAM 1741

  Fly   762 DQLEAKWRRNSLNNVGETANKQTDNFQKLIGSLSSAKPQSQAVGYDAI--SNFIMQQQQYQQQQQ 824
            ..::.....|...|:.:...:|..:      ::..::||.|..|...:  ....:|||| ||||.
Mosquito  1742 RNMQPAMPNNIPWNMKQLQQQQPQS------NVPQSQPQPQPGGPGQLMPPQLALQQQQ-QQQQN 1799

  Fly   825 KQHLIIQQQQQHTAFLASLQLKAILGRADTQLLLLRLTKGEISKHGLLVQLANPRLTDMDREAIT 889
            .|:...|||||.......:.:....||.        :.||.....|.:.|
Mosquito  1800 SQNQPQQQQQQQPQPPQHMNMPKPQGRP--------ILKGGSGNGGQMPQ--------------- 1841

  Fly   890 AVLQFTNTQQQQQQHKQQLDMLSSTVIASQLQNLHNLAIVQQTLAARQQPQH--NPQT------- 945
                  ..||||||.:||:.:            :|.|            |||  :|.|
Mosquito  1842 ------QLQQQQQQQQQQMPL------------IHPL------------PQHALSPMTGPLNFGG 1876

  Fly   946 --QAPHQLSQEDLQAHANVIMRNAVMKRKIEEQTSKLINGGAKHQAQQQYLNRGQQRQARPDANS 1008
              ..|.|..|:..|                ::|        .:.|.|||...:.||:|.:|
Mosquito  1877 NMDFPQQQQQQQQQ----------------QQQ--------QQQQQQQQQQQQQQQQQQQP---- 1913

  Fly  1009 NALLHALISGGGNNHASGYPMNGQPQKHHSNLRFGDNQNFQSFESNQPHFATQYKQQYQQSQQQH 1073
                       .||:.||.|:.|   .||........|..|  :..||        ..||.|||.
Mosquito  1914 -----------FNNNRSGNPILG---AHHPMAPPSSQQGPQ--QQQQP--------GQQQQQQQP 1954

  Fly  1074 PHQQPQQLNSLHQNNAGAVNSF------NKAQMQAQSAI-------SMLP 1110
            |||||||   ..|::...::..      .:.|||.|.||       :|:|
Mosquito  1955 PHQQPQQ---QQQHSPNMISPHMQQLLQQQRQMQQQRAIRNQHVHMNMMP 2001

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cup	NP_523493.3	EIF4E-T	425..967	CDD:371079	115/620 (19%)
LOC5666753	XP_001688305.3	None