Protein Alignment cup and EIF4ENIF1

DIOPT Version :9

• Sequence 1: NP_001285687.1
• Gene: cup / 33934
• FlyBaseID: FBgn0000392
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: XP_006724344.3
• Gene: EIF4ENIF1 / 56478
• HGNCID: 16687
• Length: 1027
• Species: Homo sapiens
• Alignment Length: 859
• Identity: 169/859 - (19%)
• Similarity: 290/859 - (33%)
• Gaps: 268/859 - (31%)

  Fly   347 SKESFVMPRIATCDDIELEGRLRRMNIWRTSDGTRFRTRSTTANLNMNNNNNNECMPAFFKNKNK 411
            ::.|:..|.:.:..|   :|.:.|.::..|..|..|        |::.....::|...:    .|
Human    24 TRGSWRRPLVQSIVD---QGAMDRRSMGETESGDAF--------LDLKKPPASKCPHRY----TK 73

  Fly   412 PNLISDESIIQSQPPQPQTEFQDPAIVNQRRIGSGRLNHSKWGYNDEDYHSYH--NGKSQHMEEV 474
            ..|:..:.:..|:        |.|:.::::....|..:..||      :.|.:  :|:|..:|.:
Human    74 EELLDIKELPHSK--------QRPSCLSEKYDSDGVWDPEKW------HASLYPASGRSSPVESL 124

  Fly   475 NSK--NSKNMTVLQFFDNGE--------ISSQPQRRPNTPVMGMSINRSENDTLHSNESSEDLSR 529
            ..:  ..:...|.:..|..|        :...||||.    .|...:.:.  .:.|..|...|.:
Human   125 KKELDTDRPSLVRRIVDPRERVKEDDLDVVLSPQRRS----FGGGCHVTA--AVSSRRSGSPLEK 183

  Fly   530 ANENY----VKRVMSGFLVVS-------------------KPKSRDVEDRHHR------------ 559
            .::..    .:|:.||.::.:                   :.:.||.:|:..|
Human   184 DSDGLRLLGGRRIGSGRIISARTFEKDHRLSDKDLRDLRDRDRERDFKDKRFRREFGDSKRVFGE 248

  Fly   560 RYRNQN---EEPEWFSCGPTSRLDTIELCGFDEDEEKMLKEGNKNHGLGETERETSKQKMDHKYK 621
            |.||.:   |||||||.||||:.:||||.|||   :|:|:|.:|  |...|.|.|:..|
Human   249 RRRNDSYTEEEPEWFSAGPTSQSETIELTGFD---DKILEEDHK--GRKRTRRRTASVK------ 302

  Fly   622 WTHAEPMGRSKYMPKHDTNNNHNVENMNNVMATEHQQQK-EEKRPGSGRSFQFDKF--NQSQQNY 683
                                 ..:...|..:|.|.:.:. ..:.|.:.:....|..  .||..::
Human   303 ---------------------EGIVECNGGVAEEDEVEVILAQEPAADQEVPRDAVLPEQSPGDF 346

  Fly   684 ESSSYVNHQQPPQTQPQQMQQQSNTNTNNSKFMSFFAN--EGNSSSSSLNEF----------FKQ 736
            :.:.:.|..:.|.............:.:.|:|..:|:|  ...|.||||...          .:|
Human   347 DFNEFFNLDKVPCLASMIEDVLGEGSVSASRFSRWFSNPSRSGSRSSSLGSTPHEELERLAGLEQ 411

  Fly   737 AI---NQGHGN-------------------------------------NPEQPKSLGHIGQMPSV 761
            ||   .|..||                                     |.|:.|...|.|.:.||
Human   412 AILSPGQNSGNYFAPIPLEDHAENKVDILEMLQKAKVDLKPLLSSLSANKEKLKESSHSGVVLSV 476

  Fly   762 DQLEAKWR--------RNS----LNNVGETANKQTDN-----------FQKLIGSL--SSAKPQS 801
            :::||..:        :||    ..::.||.:..|:|           |.||:.::  |...|..
Human   477 EEVEAGLKGLKVDQQVKNSTPFMAEHLEETLSAVTNNRQLKKDGDMTAFNKLVSTMKASGTLPSQ 541

  Fly   802 QAVGYDAISNFIMQQQQYQQQQQKQHL--IIQQQQQHTAFLASLQLKAILGRADTQLLLLRLTKG 864
            ..|..:..|:.:...:...|...|..|  ::.|..|..|  :|..|..::|..:....||    |
Human   542 PKVSRNLESHLMSPAEIPGQPVPKNILQELLGQPVQRPA--SSNLLSGLMGSLEPTTSLL----G 600

  Fly   865 EISKHGLLVQLANPRLTDMD--REAITAVLQFTNTQQQ------QQQHKQQLDMLSSTVIASQLQ 921
            :.:....|.|:...|....|  |..|.:.:.||...||      |...|..     |.:.|.|:.
Human   601 QRAPSPPLSQVFQTRAASADYLRPRIPSPIGFTPGPQQLLGDPFQGMRKPM-----SPITAQQMS 660

  Fly   922 NL-------------HNLAIV------------------------QQTLAARQQPQHNPQTQAP- 948
            .|             |:||:.                        ||.:.....|.|...:.:|
Human   661 QLELQQAALEGLALPHDLAVQAANFYQPGFGKPQVDRTRDGFRNRQQRVTKSPAPVHRGNSSSPA 725

  Fly   949 ------HQLSQEDLQAHANVIMRNAVMKRKIEEQTSKLINGGAKHQAQ----QQYLNRGQQRQAR 1003
                  ..||...........|..:..|.|.|..:.|...|.:|...|    :..|:......|.
Human   726 PAASITSMLSPSFTPTSVIRKMYESKEKSKEEPASGKAALGDSKEDTQKASEENLLSSSSVPSAD 790

  Fly  1004 PDAN--SNALLHAL 1015
            .|::  :|:.|.||
Human   791 RDSSPTTNSKLSAL 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cup	NP_001285687.1	DUF2477	227..>305	CDD:287586
EIF4ENIF1	XP_006724344.3	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157425
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006297
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12269
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.030