Protein Alignment cup and 4E-T

DIOPT Version :9

• Sequence 1: NP_001285687.1
• Gene: cup / 33934
• FlyBaseID: FBgn0000392
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: NP_726618.3
• Gene: 4E-T / 43836
• FlyBaseID: FBgn0052016
• Length: 1010
• Species: Drosophila melanogaster
• Alignment Length: 933
• Identity: 207/933 - (22%)
• Similarity: 333/933 - (35%)
• Gaps: 258/933 - (27%)

  Fly   341 NALMHRS-KESFVMPRIATCDDIELEGRLRRMNIWRTSDGTRFRTRSTTANLNMNNNNNNEC--- 401
            |.:.||| ..|.:||..|.          ||..|            |..:|...:|...|.|
  Fly   128 NIIDHRSISSSHLMPAFAK----------RRFVI------------SKGSNSEESNEGINTCASK 170

  Fly   402 -MPAFFKNKNKPNLISDESIIQ-SQPPQPQTEFQDPAIV---NQRRIGSGRL--NHSKWGYNDED 459
             ..|...::....|.:.|:.:. .||...|.....|...   .:||||||||  ....|.|
  Fly   171 GKAASSPSRKGSELDTAETCLNFVQPDHDQCMSSSPTFSTSRQERRIGSGRLLPRSDNWDY---- 231

  Fly   460 YHSYHNGKSQHMEEVNSKNSKNMTVLQFFDNGEIS-------SQPQRRPNTPVMGMSINR--SEN 515
                   |::...|.:.:|.|..:     .||..|       :|.|.|..| ..|..:.|  ...
  Fly   232 -------KNEKTVEASIENEKETS-----PNGSGSTSSLNQHNQSQHRSRT-FSGRLVERVPEVT 283

  Fly   516 DTLHSNESSEDLSRANENYVKRVMSGFLVVSKPKSRDVEDRHHRRYRNQNEEPEWFSCGPTSRLD 580
            |.....:|.:...|...|  .|.:||    .:|.|.....:....|. .:|||||||.||.|:|:
  Fly   284 DRRFQYDSKKSFDRQGIN--NRRISG----KEPFSTQSRSKRGNSYL-IHEEPEWFSAGPKSQLE 341

  Fly   581 TIELCGFDE---DEEKMLKEGNKNHGLGETERETSKQKMDHKYKWTHAEPMGRSKYMPKHDTNNN 642
            ||:|.||::   :||:.:.| :||:.:.:.::....|               .||  .:....|:
  Fly   342 TIDLHGFEDLEKNEERSVTE-DKNNQIQQLDKNLDAQ---------------ASK--DEASMRNS 388

  Fly   643 HNVENMNNVMATEHQQQKEEKRPGSGRSFQFDKFNQSQQNYESSSYVNHQQPPQTQPQQMQQQSN 707
            ::..|...|:.::.::..:|            ....|.||.....:.|..:|.|.||   .|...
  Fly   389 NDSLNFREVIPSDEKKHTDE------------NVVTSIQNSTDLGHPNKNKPIQMQP---SQNPE 438

  Fly   708 TNTNNSKFM-------SFFANE--GNSSSSSLNEFFKQAINQGHGNNPEQPKSLGHIGQ----MP 759
            :..|...|:       |..:|:  |.|.|...:.|.:....:...||.|.|.......|    :|
  Fly   439 SEFNFDAFLNMHPLDNSVLSNDETGKSDSKGTSRFSRWFRQKEAANNNEFPGFRESHAQEKRGIP 503

  Fly   760 SVDQLEAK-----WRRNSLNNVG----ETAN------KQTDNFQKLIGSLSSAKPQ-------SQ 802
            ||..|||:     .|.:.:|.:.    :|..      :.|:.|:||:..|.|...|       .:
  Fly   504 SVKDLEAQMIKVDMRTDLINPIAGSLCQTVQMEKPIARDTEAFKKLLQQLGSQARQHHPCNDDCR 568

  Fly   803 AVGYDAISNFIMQQQQYQQQQQKQHLIIQQQQQHTAFLASLQLKA---ILGRADTQLLLLRLTKG 864
            .:....|:|.:..:.:..|:....||   ||.:.:..:.::...:   :..|.:.|.|:.||..|
  Fly   569 TINLSNIANHVHLESKLHQKINDGHL---QQPELSVNVPTMPTSSHVFLQKRLEIQHLIQRLHCG 630

  Fly   865 EISKHGLLVQLANPRLTDMDREAITAVL----------------------QFTNTQQQQQQHKQQ 907
            ::|...|..:|.||......::.|..||                      .|...|...|.:.|:
  Fly   631 DVSHDFLEKELDNPSTPAATKDVIATVLNEYSHSKRNPVVTGDPNIFTQQSFLQPQSVHQHYSQE 695

  Fly   908 L---DMLSSTVIASQLQNLHN---------LAIVQQTLAAR--QQPQ---HNPQTQAPHQLSQED 955
            |   :..:.|:  :||.:..|         .:::::..|.:  |.|.   .|||... ||.:.:.
  Fly   696 LHSQNTANHTI--NQLISHGNSPTPLAFTPTSVLRKMTADKDTQSPSTYCQNPQYHV-HQQNAKQ 757

  Fly   956 LQAHANVIMRNAVMKRKIEEQTSKLINGGA--------KHQAQQQYLNRGQQRQARPDANSNALL 1012
            :....||:.........::   .::|.||.        :|.:.....:|.||.......|.. ::
  Fly   758 VGTRENVLEPQLTATMAVQ---PRMILGGGNFAIGQNNQHLSPNMSQSRNQQVLKWTSGNMQ-MV 818

  Fly  1013 HA------LISGGGNN--HA-SGYPMNG---------QPQKHHSNLRFGDNQNFQSFESN----- 1054
            |.      ::.||.|:  |: |..|...         ||.......||   :..||.|||
  Fly   819 HGKTFGRPILKGGLNSMPHSNSALPFTAHKIEMQPIHQPHLQQQQHRF---KAVQSVESNLNTES 880

  Fly  1055 ------QPHFATQYKQQYQQSQQQHPHQQPQQLN------SLHQ----------------NNAGA 1091
                  .|   ..:.|.|.|.||||.|.: |||:      .:|:                :::|.
  Fly   881 VHQNITSP---VGWHQLYMQHQQQHHHTR-QQLSQRVIYGEMHRQSNPQMSPPVPGFSDSSDSGN 941

  Fly  1092 V---NSFNKAQMQAQSAISMLPN 1111
            |   ||......|....||...|
  Fly   942 VIKANSLTSPSYQRDERISSPTN 964

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cup	NP_001285687.1	DUF2477	227..>305	CDD:287586
4E-T	NP_726618.3	EIF4E-T	10..736	CDD:371079	153/691 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466611
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006297
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12269
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.030