Protein Alignment cup and Eif4enif1

DIOPT Version :10

• Sequence 1: NP_523493.3
• Gene: cup / 33934
• FlyBaseID: FBgn0000392
• Length: 1117
• Species: Drosophila melanogaster
• Sequence 2: XP_006251352.1
• Gene: Eif4enif1 / 305468
• RGDID: 1560908
• Length: 1004
• Species: Rattus norvegicus
• Alignment Length: 826
• Identity: 167/826 - (20%)
• Similarity: 292/826 - (35%)
• Gaps: 248/826 - (30%)

  Fly   359 CDDIELEGRLRRMNIWRTSDGTRFRTRSTTANLNMNNNNNNECMPAFFKNKNKPNLISDESIIQS 423
            |..|..:..:.:.::..|.:|..|        |::..      :|    ....|:..:.|.::..
  Rat    11 CKKIVHQEAMEKRSVDETENGDAF--------LDLKK------LP----TSKSPHRYTKEELLDI 57

  Fly   424 QPPQPQTEFQDPAIVNQRRIGSGRLNHSKWGYNDEDYHSYH--NGKSQHMEEVNSK-NSKNMTVL 485
            : .:|.:: |.|:.::::....|..:..||      :.|.:  :|:|..:|.:..: .|...:::
  Rat    58 K-ERPYSK-QRPSCLSEKYDSDGVWDPEKW------HASLYPASGRSSPVESLKKEPESDRPSLV 114

  Fly   486 QFF---------DNGEISSQPQRRPNTPVMGMSINRSENDTLHSNESSEDLSRANENY----VKR 537
            :..         |:.::...||||.    .|...:.:.  .:.|..|...|.:.::..    .:|
  Rat   115 RRIADPRERVKEDDLDVVLSPQRRS----FGGGCHVTA--AVSSRRSGSPLEKDSDGLRLLGGRR 173

  Fly   538 VMSGFLVVS-------------------KPKSRDVEDRHHR------------RYRNQN---EEP 568
            :.||.::.:                   :.:.||.:|:..|            |.||.:   |||
  Rat   174 IGSGRIISARAFEKDHRLSDKDLRDLRDRDRERDYKDKRFRREFGDSKRVFGERRRNDSYTEEEP 238

  Fly   569 EWFSCGPTSRLDTIELCGFDEDEEKMLKEGNKNHGLGETERETSKQKMDHKYKWTHAEPMGRSKY 633
            ||||.||||:.:||||.|||   :|:|:|.:|  |...|.|.|:..:
  Rat   239 EWFSAGPTSQSETIELTGFD---DKILEEDHK--GRKRTRRRTASVR------------------ 280

  Fly   634 MPKHDTNNNHNV---ENMNNVMATEHQQQKE--------EKRPGSGRSFQFDKFNQSQQNYESSS 687
              :.....|..|   :.:..::|.|....:|        |:.||     :|| ||:
  Rat   281 --EGIVECNGGVAEEDEVEVILAQEPSADQEVPRDVILPEQSPG-----EFD-FNE--------- 328

  Fly   688 YVNHQQPPQTQPQQMQQQSNTNTNNSKFMSFFAN--EGNSSSSSLNEF----------FKQAI-- 738
            :.|..:.|.............:.:.|:|..:|:|  ...|.||||...          .:||:
  Rat   329 FFNLDKVPCLASMIEDVLGEGSVSASRFSRWFSNPSRSGSRSSSLGSTPHEELERLAGLEQAVLS 393

  Fly   739 -NQGHGNNPEQPKSLGHIGQMPSVDQLEAKWRRNSLNNVGETANKQTDNFQKLIGSLSSAKPQSQ 802
             .|..||         :...:||.|..|.|      .::.|...|...:.:.|:.|||:.|.:.:
  Rat   394 PGQNSGN---------YFAPIPSEDHAENK------VDILEMLQKAKVDLKPLLSSLSANKEKLK 443

  Fly   803 AVGYDAISNFIMQQQQYQQQQQKQHLIIQQQQQHTAFLASLQLKAILGRADTQLLLLRLTKGEIS 867
            ...:   |..::..::. :...|...:.||.:..|.|:|. .|:..|...        .:..::.
  Rat   444 ESSH---SGVVLSVEEV-EAGLKGLKVDQQIKNSTPFMAE-HLEETLSAV--------TSNRQLK 495

  Fly   868 KHGLLVQLANPRLTDMDREAITAVLQFTNTQQQQQQHKQQLDMLSSTVIASQLQNLHNLAIVQQT 932
            |.|           ||     ||..:..||            |.:|..:.:|.:...||   :..
  Rat   496 KDG-----------DM-----TAFNKLVNT------------MKASGTLPTQPKVSRNL---ESH 529

  Fly   933 LAARQQPQHNPQTQAPHQLSQE----DLQAHANVIMRNAVMKRKIEEQTSKLINGGAKHQAQQQY 993
            |.|   |...|....|..:.||    .:|..|:..:.:.:|...  |.|:.|::..|......|.
  Rat   530 LLA---PAEIPGQPVPKNILQELLGQPVQRPASSNLLSGLMGSL--EPTASLLSQRAPSPPMSQV 589

  Fly   994 LNRGQQRQARPDANSNALLHALISGGGNNHASGYPMNGQPQKHHSNLRFGDNQNFQSFESNQPHF 1058
            .        |..|.|...||..|..     ..|:|..  ||:     ..||  .||.........
  Rat   590 F--------RTQAASADYLHPRIPS-----PIGFPSG--PQQ-----LLGD--PFQGMRKPMSPV 632

  Fly  1059 ATQYKQ-QYQQSQQQH---PHQQPQQLNSLHQNNAGAVNSFNKAQM 1100
            ..|..| :.||:..:.   ||....|....:|      ..|:|.|:
  Rat   633 TAQMSQLELQQAALEGLTLPHDLAVQTTPFYQ------PGFSKPQV 672

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cup	NP_523493.3	EIF4E-T	425..967	CDD:371079	127/621 (20%)
Eif4enif1	XP_006251352.1	EIF4E-T	49..730	CDD:371079	159/770 (21%)