DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG13771 and ACOT9

DIOPT Version :9

Sequence 1:	NP_609061.2	Gene:	CG13771 / 33933	FlyBaseID:	FBgn0031844	Length:	451	Species:	Drosophila melanogaster
Sequence 2:	NP_001032248.1	Gene:	ACOT9 / 23597	HGNCID:	17152	Length:	448	Species:	Homo sapiens

Alignment Length:	394	Identity:	128/394 - (32%)
Similarity:	195/394 - (49%)	Gaps:	25/394 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 VAKKIREHVGVEGGY--HI-IPKSRDGLLKFQPK-QDELPNRSMLDSQTTAQVLLETDALLRQRF 108
            |..|:||.||....:  |: ..:.|..|..|..| ||.||.|.|.||.....:.|.::..||:::
Human    49 VRDKLREIVGASTNWRDHVKAMEERKLLHSFLAKSQDGLPPRRMKDSYIEVLLPLGSEPELREKY 113

  Fly   109 VYGRGLLRMGRIIEELDLLAVWICHLH--IHLPNLPEGVPLPYTFITMLVDHAHFLQDKFIADAD 171
            :..:..:|.|||:|:||.|.|.||::|  ||...:.     |.:.:|.|||.....:.....:.|
Human   114 LTVQNTVRFGRILEDLDSLGVLICYMHNKIHSAKMS-----PLSIVTALVDKIDMCKKSLSPEQD 173

  Fly   172 VSLSGHVSYTDNNFMEVTAYVRQ----SGMLLAKGIFVVEARDAINNGPAPVNPLVPANELEESL 232
            :..|||||:.....|||...:.|    ....:....||:.|||:.|.|||.||||:|.:..||.|
Human   174 IKFSGHVSWVGKTSMEVKMQMFQLHGDEFCPVLDATFVMVARDSENKGPAFVNPLIPESPEEEEL 238

  Fly   233 HQEAQKRHQER-AKALYRLESQQPTKEEQQLMYELFTRTKGDDGPSPSDMT----TLPPNSRWMS 292
            .::.:.....| |.:...|....|:.||:..::|:|..|.     .|..::    .||.|:.||.
Human   239 FRQGELNKGRRIAFSSTSLLKMAPSAEERTTIHEMFLSTL-----DPKTISFRSRVLPSNAVWME 298

  Fly   293 TWRRRTLMHPFPENRNESNTIFGGFIIRKAIEISYMTASLYSNQRCMIRFIADVTFAHSIPVHSY 357
            ..:.::|....|:.||..|.|||||::|||.|:::.||..:...|..:..:.|:.|...:.|.|.
Human   299 NSKLKSLEICHPQERNIFNRIFGGFLMRKAYELAWATACSFGGSRPFVVAVDDIMFQKPVEVGSL 363

  Fly   358 IKLKAYVVFTHENYIQLLTVVNAIDGNSFTELKCNVLHLTYSCSKAVPEILPRSYHEALWYLTGR 422
            :.|.:.|.||..||||:.................||.|.|:...|.||.:.|::|.|::.||.|:
Human   364 LFLSSQVCFTQNNYIQVRVHSEVASLQEKQHTTTNVFHFTFMSEKEVPLVFPKTYGESMLYLDGQ 428

  Fly   423 RYFN 426
            |:||
Human   429 RHFN 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG13771	NP_609061.2	BFIT_BACH	91..220	CDD:239526	41/134 (31%)
CG13771	NP_609061.2	BFIT_BACH	289..400	CDD:239526	35/110 (32%)
ACOT9	NP_001032248.1	BFIT_BACH	101..226	CDD:239526	41/129 (32%)
ACOT9	NP_001032248.1	BFIT_BACH	295..404	CDD:239526	34/108 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151887
Domainoid	1	1.000	268	1.000	Domainoid score	I1868
eggNOG	1	0.900	-	-		E1_COG1607
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H8206
Inparanoid	1	1.050	268	1.000	Inparanoid score	I3034
Isobase	1	0.950	-	0	Normalized mean entropy	S5060
OMA	1	1.010	-	-		QHG55517
OrthoDB	1	1.010	-	-		D786592at2759
OrthoFinder	1	1.000	-	-		FOG0002448
OrthoInspector	1	1.000	-	-		otm41069
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12655
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1631
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820