DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11070 and UBE4A

DIOPT Version :9

Sequence 1:	NP_609060.1	Gene:	CG11070 / 33932	FlyBaseID:	FBgn0028467	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_004779.2	Gene:	UBE4A / 9354	HGNCID:	12499	Length:	1073	Species:	Homo sapiens

Alignment Length:	1107	Identity:	377/1107 - (34%)
Similarity:	551/1107 - (49%)	Gaps:	170/1107 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SIEENPFAALL---------------QEGANSDGVP----------------------------- 23
            :|..||||||.               |....||.:|
Human     9 NISSNPFAALFGSLADAKQFAAIQKEQLKQQSDELPASPDDSDNSVSESLDEFDYSVAEISRSFR 73

  Fly    24 -----------HKLVEEVLLFTLNKAS---------SSAVLCLADVVVE-TSEEMLSEDLVAHAL 67
                       :.:::.:.|.||:.:.         .|..:.|.::.|| ..::.|....|..||
Human    74 SQQEICEQLNINHMIQRIFLITLDNSDPSLKSGNGIPSRCVYLEEMAVELEDQDWLDMSNVEQAL 138

  Fly    68 FERLMLAETSQYAAG---------NASEMAMERRAMRYLKGAFTRCGLIQAERKIDCSKI----- 118
            |.||:|.:...:...         :|...|.||....||...|.|.       |.:.:|:
Human   139 FARLLLQDPGNHLINMTSSTTLNLSADRDAGERHIFCYLYSCFQRA-------KEEITKVPENLL 196

  Fly   119 ------LALILNNASTCMRQPDLFAPQSFGAQWME-MFEQDEDEHDTSTQEFLIRVTCKVMEEVE 176
                  ..|.::|..|.:..|:::..|:...|.:: |.|..:...:...:.:...|| :.:|||
Human   197 PFAVQCRNLTVSNTRTVLLTPEIYVDQNIHEQLVDLMLEAIQGAREYMNKIYFEDVT-EFLEEV- 259

  Fly   177 PIEAL------GALKAIFYPVLTELQKNIAKLNLITMKKNTFW-ILGYFVRDKRAAVLGELLIDY 234
             ||||      .....:..||...|...|..|.|..:....:. ||.||.|.|..|   ::.::|
Human   260 -IEALILDEEVRTFPEVMIPVFDILLGRIKDLELCQILLYAYLDILLYFTRQKDMA---KVFVEY 320

  Fly   235 TTPNPRASGSEYMDTLLGSLLCISILPKTQ--TGKYEFF--------QELSINQTDEALWALLSH 289
            ..|....:|..|..||||.:|.||.|.||.  ...:.:|        ||:.:.:.:  :...::.
Human   321 IQPKDPTNGQMYQKTLLGVILSISCLLKTPGVVENHGYFLNPSRSSPQEIKVQEAN--IHQFMAQ 383

  Fly   290 HQQSIFLLVKQLLVLSPETKKKTLQWVGNCLDANVPRGHLWSSINASLEQTAHSTSSDAFMTNLT 354
            ..:.|:.::|.||.||||||...|.|:||||.||..|..:|:  |...|......:||||..||.
Human   384 FHEKIYQMLKNLLQLSPETKHCILSWLGNCLHANAGRTKIWA--NQMPEIFFQMYASDAFFLNLG 446

  Fly   355 AVLVRLCAPLCMP-SLKVLLVDPTYCAVP---NKDRQAKGVSMLRAHAETCLLTSEEGEERLTAE 415
            |.|::||.|.|.| |.::|..:|||||:.   :::|:.|.|.|.....||||:.:.  :|....:
Human   447 AALLKLCQPFCKPRSSRLLTFNPTYCALKELNDEERKIKNVHMRGLDKETCLIPAV--QEPKFPQ 509

  Fly   416 KYNFVTEIFYMTHKCFELSNIPCIERFVRVLRELQNTQMAYGEIVNSDPNSEVAKNLFRMIRDQI 480
            .||.|||...:|.....|......::.|::.:.|...|:|:.:...|  :|..|.||    |:|.
Human   510 NYNLVTENLALTEYTLYLGFHRLHDQMVKINQNLHRLQVAWRDAQQS--SSPAADNL----REQF 568

  Fly   481 QQVLTI----KNTLAEPTNDMYLLKFFEASAIWLTEIAMLPREIYEQCLDKRDFSPQVFRNMELL 541
            ::::||    |..:.||......|....:.|:.|.::|          :......|     :||
Human   569 ERLMTIYLSTKTAMTEPQMLQNCLNLQVSMAVLLVQLA----------IGNEGSQP-----IEL- 617

  Fly   542 SDTPPFVAPY--MQSVPESIIDNISAFLNAARKLNGEQYINIYFSAHDAFFKMIILFMGSSALVK 604
              |.|....|  :..|||...||:..||...|:. .:..:.....:.:.....|.:|.||...:|
Human   618 --TFPLPDGYSSLAYVPEFFADNLGDFLIFLRRF-ADDILETSADSLEHVLHFITIFTGSIERMK 679

  Fly   605 NPHLRAKLAEALEFLL------PSRIMGS--HRKTFVSHVFDNHPDRLKVVRSLLNVFVSIEMTG 661
            ||||||||||.||.::      |:.::.|  |||    .||.|.....::..:|:.|||.||.||
Human   680 NPHLRAKLAEVLEAVMPHLDQTPNPLVSSVFHRK----RVFCNFQYAPQLAEALIKVFVDIEFTG 740

  Fly   662 QSVQFEQKFNYRRPMYAIMEFLWTKPEHVQCFRDLAVEAEQNMDAIEPPIFLRFINLLINDAIFL 726
            ...|||||||||||||.|:.::|....:.:..:|||..|.:|::|:.||:||||:|||:||||||
Human   741 DPHQFEQKFNYRRPMYPILRYMWGTDTYRESIKDLADYASKNLEAMNPPLFLRFLNLLMNDAIFL 805

  Fly   727 LDESLSNLEQIKQLQQAQDNGEWESLPHTEREQHMTNLQHLGMLARFDNIIGRDTINLLKLLTSK 791
            |||::..|.:||..|..:|.|||:||....|.:....||..|.||||.||:..:||..|..|||:
Human   806 LDEAIQYLSKIKIQQIEKDRGEWDSLTPEARREKEAGLQMFGQLARFHNIMSNETIGTLAFLTSE 870

  Fly   792 IKSIFCHNSMVDRMAAMLNYFLLNLVGPKKERFKVKDKKEFEFDPAQTVIEISHIYINLSSDESF 856
            |||:|.|..:.:|:.:||||||.:|||||....||||..||:|.|.|.|.:|..||:||..:|:|
Human   871 IKSLFVHPFLAERIISMLNYFLQHLVGPKMGALKVKDFSEFDFKPQQLVSDICTIYLNLGDEENF 935

  Fly   857 CLAVSQDGRSYSEQLFSYAENILIRIG-GGQLIGDMSEFAVKVARMGAQYKEEQELLADAPEEYL 920
            |..|.:||||||..||:....:|.:|. .|.:|...|..|.::..:....::|:|..|||.:|:|
Human   936 CATVPKDGRSYSPTLFAQTVRVLKKINKPGNMIMAFSNLAERIKSLADLQQQEEETYADACDEFL 1000

  Fly   921 DPIISTLMTDPVVLPSSKVTVDRSTIARHLLSDQTDPFNREPLTMDKVKSNEALKQEIESWIQGK 985
            |||:||||.||||||||:||||||||||||||||||||||.|||||:::.|..||::|:.|:..:
Human  1001 DPIMSTLMCDPVVLPSSRVTVDRSTIARHLLSDQTDPFNRSPLTMDQIRPNTELKEKIQRWLAER 1065

  Fly   986 RE 987
            ::
Human  1066 KQ 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11070	NP_609060.1	Ufd2P_core	251..898	CDD:287392	251/675 (37%)
CG11070	NP_609060.1	U-box	915..987	CDD:252675	50/71 (70%)
UBE4A	NP_004779.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..56		4/22 (18%)
		UFD2	170..1068	CDD:227444	349/946 (37%)
		Ufd2P_core	337..978	CDD:287392	251/675 (37%)
		U-box	995..1067	CDD:252675	50/71 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147676
Domainoid	1	1.000	373	1.000	Domainoid score	I898
eggNOG	1	0.900	-	-		E1_COG5113
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3517
Inparanoid	1	1.050	523	1.000	Inparanoid score	I1263
Isobase	1	0.950	-	0	Normalized mean entropy	S3949
OMA	1	1.010	-	-		QHG53881
OrthoDB	1	1.010	-	-		D194967at2759
OrthoFinder	1	1.000	-	-		FOG0006865
OrthoInspector	1	1.000	-	-		oto90039
orthoMCL	1	0.900	-	-		OOG6_108713
Panther	1	1.100	-	-	LDO	PTHR13931
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4960
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720