DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11070 and UFD2

DIOPT Version :9

Sequence 1:	NP_609060.1	Gene:	CG11070 / 33932	FlyBaseID:	FBgn0028467	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_010091.2	Gene:	UFD2 / 851337	SGDID:	S000002349	Length:	961	Species:	Saccharomyces cerevisiae

Alignment Length:	891	Identity:	237/891 - (26%)
Similarity:	408/891 - (45%)	Gaps:	119/891 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 STQEFLIRVTCKVMEEVEPIEALGALKAIFYPVLTELQKNIA--KLNLITMKKNTFWILGYFVRD 221
            |..:||.::..:.:.|.   .||..|.|:|..:|....|:::  .||...:..|...|...||..
Yeast   126 SYTDFLSQIIQRAILEG---TALDLLNAVFPTLLEYCNKHVSHFDLNESVIYNNVLTIFELFVTF 187

  Fly   222 KRAA----VLGELLIDYTTPNPRASGSEYMDTLLGSLLCISILPKTQTGKYEFFQEL--SINQTD 280
            |..|    .:.....||:. .|:....:   |:||.:|.:|.: :.......:...|  |..||.
Yeast   188 KPIAEIFTKIDGFFADYSC-KPQDFERK---TILGPILSLSPI-EAAVAIRNYGDNLLRSKQQTA 247

  Fly   281 EALWALLSHHQ---QSIFLLVKQLLVLSPETKKKTLQWVGNCLDANVPRGHLWSSINASLEQTAH 342
            ....:|.:.|:   ..:|.:|.:|:..|..::...:.:..:..:.|    ||..:.:...::
Yeast   248 MIHESLQAEHKVVIDRLFFIVDKLVRGSLNSRTDMISYFAHIANKN----HLRRADHPPFKE--- 305

  Fly   343 STSSDAFMTNLTAVLVRLCAP-LCMPSLKVLLVDPTYCAVPNKDRQAKGVSMLRAHAETCLLTSE 406
             .||:.||:|:|.:|||...| |.:...|:..:|..|...|:......|.:.|.:..:..  .:.
Yeast   306 -LSSNGFMSNITLLLVRFSQPFLDISYKKIDKIDANYFNNPSLFIDLSGETRLNSDFKEA--DAF 367

  Fly   407 EGEERLTAE-KYNFVTEIFYMT----H------KCFEL---SNIPCIERFVRVLRELQNTQMAYG 457
            ..:.|.||: |.||:::.|::|    |      ..||.   |.|..::..:..::::......:.
Yeast   368 YDKNRKTADSKPNFISDCFFLTLTYLHYGLGGTLSFEEKMGSEIKALKEEIEKVKKIAANHDVFA 432

  Fly   458 EIVNSD-PNSEVAKNLFRMIRDQIQQVLTIKNTLAEPTNDMYLLKFFEASAIWLTEIA------- 514
            ..:.:. ...|.|......:|      ..::...|..:..:.:..|...::.:|..:.
Yeast   433 RFITAQLSKMEKALKTTESLR------FALQGFFAHRSLQLEVFDFICGASTFLIRVVDPEHEFP 491

  Fly   515 -------MLPREIYEQCLDKRDFSPQVFRNMELLSDTP-PFVAPYMQSVPESIIDNISAFLNAAR 571
                   ::|.:|..:.:|..||         |.:..| ||     :..||.:::.
Yeast   492 FKQIKLPLIPDQIGVENVDNADF---------LRAHAPVPF-----KYYPEFVVEG--------- 533

  Fly   572 KLNGEQYINIYFSAH-------DAFFKMIILFMGSSALVKNPHLRAKLAEALEF-LLPSRIMGSH 628
            .:|...||:.|.::.       .:|.:...:.:....||.||||:.||.:.|.. .:|   :..:
Yeast   534 PVNYSLYISKYQTSPIFRNPRLGSFVEFTTMVLRCPELVSNPHLKGKLVQLLSVGAMP---LTDN 595

  Fly   629 RKTFVSHVFDNHPDRL---KVVRSLLNVFVSIEMTGQSVQFEQKFNYRRPMYAIMEFLWTK-PEH 689
            ...|:..:|::  |.|   .::.:||:.:|.:|.||.|.||..|||.|..:..|:|.|:.| |.:
Yeast   596 SPGFMMDIFEH--DELVNKNLLYALLDFYVIVEKTGSSSQFYDKFNSRYSISIILEELYYKIPSY 658

  Fly   690 VQCFRDLAVEAEQNMDAIEPPIFLRFINLLINDAIFLLDESLSNLEQIKQLQQAQDNGEWESLPH 754
            .   ..|..:::.|.|     .|:||:..::||..|||||.||||.::..:|...||....:.|.
Yeast   659 K---NQLIWQSQNNAD-----FFVRFVARMLNDLTFLLDEGLSNLAEVHNIQNELDNRARGAPPT 715

  Fly   755 TERE--QHMTNLQHLGMLARFDNIIGRDTINLLKLLTSKIKSIFCHNSMVDRMAAMLNYFLLNLV 817
            .|.|  :..|.|......|:....:...::.|.::.:..|.:.|....:|.|:|:||||.|.:||
Yeast   716 REEEDKELQTRLASASRQAKSSCGLADKSMKLFEIYSKDIPAAFVTPEIVYRLASMLNYNLESLV 780

  Fly   818 GPKKERFKVKDKKEFEFDPAQTVIEISHIYINLSSDESFCLAVSQDGRSYSEQLFSYAENILIR- 881
            |||....||||.:.:.|:|...:..::.:|||||....|..||::|.||::..||..|.:||.|
Yeast   781 GPKCGELKVKDPQSYSFNPKDLLKALTTVYINLSEQSEFISAVAKDERSFNRNLFVRAVDILGRK 845

  Fly   882 --IGGGQLIGDMSEFAVKVARMGAQYKEEQELLADAPEEYLDPIISTLMTDPVVLPSSKVTVDRS 944
              :...:.|..:..||.|........:||.....|.|:|:|||::.|:|.|||:||:||:.:|||
Yeast   846 TGLASPEFIEKLLNFANKAEEQRKADEEEDLEYGDVPDEFLDPLMYTIMKDPVILPASKMNIDRS 910

  Fly   945 TIARHLLSDQTDPFNREPLTMDKVKSNEALKQEIESWIQGKREAAR 990
            ||..|||||.||||||.||.::.|..||.|:|:|..:.:.|:|.|:
Yeast   911 TIKAHLLSDSTDPFNRMPLKLEDVTPNEELRQKILCFKKQKKEEAK 956

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11070	NP_609060.1	Ufd2P_core	251..898	CDD:287392	169/699 (24%)
CG11070	NP_609060.1	U-box	915..987	CDD:252675	39/71 (55%)
UFD2	NP_010091.2	UFD2	1..961	CDD:227444	237/891 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343958
Domainoid	1	1.000	87	1.000	Domainoid score	I1856
eggNOG	1	0.900	-	-		E1_COG5113
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53881
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13931
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1598
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.880