DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11070 and Ube4b

DIOPT Version :9

Sequence 1:	NP_609060.1	Gene:	CG11070 / 33932	FlyBaseID:	FBgn0028467	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	XP_036020183.1	Gene:	Ube4b / 63958	MGIID:	1927086	Length:	1465	Species:	Mus musculus

Alignment Length:	1089	Identity:	274/1089 - (25%)
Similarity:	468/1089 - (42%)	Gaps:	244/1089 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SIEENPFAALLQE--GANSDGVPHKLVEEVLLFTLNKASSSAVLCLADVVVETSEEMLSE----D 61
            |:..:||:.|..|  |.:||.      :|                      |..||.|.|    |
Mouse   516 SMSNSPFSFLFLELSGDSSDD------DE----------------------EEDEEELDEGGGDD 552

  Fly    62 LVAHALFERLMLAETSQYAAGNAS-----------EMAMERRAMRYLKGAFTRCGLIQAERKIDC 115
            ..::..|      .:|..|:|.||           |...|...:.||...|.|.|:.:.:....|
Mouse   553 DFSYVQF------GSSLGASGGASNWDSYSDHFTIETCKETDMLNYLIECFDRVGIEEKKAPKMC 611

  Fly   116 SK--ILALILNNASTC-----------------MRQPDLFAPQSFGAQWMEMFEQDEDEHDTSTQ 161
            |:  :..|:.|..|.|                 ::||....|..........|.|:
Mouse   612 SQPAVSQLLSNIRSQCISHTALVLQGSLTQPRSLQQPSFLVPYMLCRNLPYGFIQE--------- 667

  Fly   162 EFLIRVTCKVMEEVEPIEALGALKAIFYPVLTELQKNIAKLNLITMKKNTFWILGYFVRDKRAAV 226
              |:|.|.: .|||        .|.||.|:|..|.....:.:|.:         .||.....|
Mouse   668 --LVRTTHQ-DEEV--------FKQIFIPILQGLALAAKECSLES---------DYFKYPLMA-- 710

  Fly   227 LGELL---IDYTTPN-----------PRA----SGSEYMD-TLLGSLLCISILPKTQ---TGKYE 269
            ||||.   ...|.|.           |::    ||.|... :.||:....|:..:..   ..||.
Mouse   711 LGELCETKFGKTHPMCNLVASLPLWLPKSLSPGSGRELQRLSYLGAFFSFSVFAEDDAKVVEKYF 775

  Fly   270 FFQELSINQT---DEALWALLSHHQQSIFLLVKQLLVLSPETKKKTLQWVGNCLDANVPRGHLWS 331
            ....:::..|   .::|...|...:|.:|.::..:| |:.||::..|.::...::||:.:
Mouse   776 SGPAITLENTRVVSQSLQHYLELGRQELFKILHSIL-LNGETREAALSYMAALVNANMKK----- 834

  Fly   332 SINASLEQTAHSTSSDAFMTNLTAVLVRLCAPLCMPSLKVLLVDPTY-----CAV--PNKDRQAK 389
               |.::......|:|.||.||..||.:|..     .:|:..|||||     |.:  ||.:.:..
Mouse   835 ---AQMQADDRLVSTDGFMLNLLWVLQQLST-----KIKLETVDPTYIFHPRCRITLPNDETRIN 891

  Fly   390 GVSMLRAHAETCLLTSEEGEERLTAEKY---------NFVTEIFYMTHKCFELSNIPCIERFVRV 445
            .             |.|:..|||| |.|         .|.||.|::|.....||.:|...|::|.
Mouse   892 A-------------TMEDVNERLT-ELYGDQPPFSEPKFPTECFFLTLHAHHLSILPSCRRYIRR 942

  Fly   446 LRELQNTQMAYGEIVNSD------PNSEVAKNLFRMIRDQIQQVLTIKNTLAEPTNDMYLLKFFE 504
            ||.::.......::.|::      |.:...:.:.:..:.|:::::..|
Mouse   943 LRAIRELNRTVEDLKNNESQWKDSPLATRHREMLKRCKTQLKKLVRCK----------------- 990

  Fly   505 ASAIWLTEIAMLPREIYEQCLDKRDFSPQVFR----------NMELLSDTPPFVAPYMQSVPESI 559
            |.|    :..:|......:||:......|:..          .:.|.|:.|...|    ::||..
Mouse   991 ACA----DAGLLDESFLRRCLNFYGLLIQLMLRILDPAYPDVTLPLNSEVPKVFA----ALPEFY 1047

  Fly   560 IDNISAFLNAARKLNGEQYINIYFSAHDAFFKMIILFMGSSALVKNPHLRAKLAEALEFLLPSRI 624
            :::::.||....:.:.:.   :|..........:::.:.:...::||:|.|||.|.:....|| :
Mouse  1048 VEDVAEFLFFIVQYSPQV---LYEPCTQDIVMFLVVMLCNQNYIRNPYLVAKLVEVMFMTNPS-V 1108

  Fly   625 MGSHRKTFVSHVFDNHPDRLK-VVRSLLNVFVSIEMTGQSVQFEQKFNYRRPMYAIMEFLWTKPE 688
            ....:|.|  .:.:|||...| :|.||:..:..:|.||.:.:|..||..|..:..|.:.||....
Mouse  1109 QPRTQKFF--EMIENHPLSTKLLVPSLMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNIA 1171

  Fly   689 HVQCFRDLAVEAEQNMDAIEPPIFLRFINLLINDAIFLLDESLSNLEQIKQLQQAQDNGE-WESL 752
            |...|.:.....:|         |:|:||:||||..|||||||.:|::|.::|:...|.| |:.|
Mouse  1172 HHGTFMEEFNSGKQ---------FVRYINMLINDTTFLLDESLESLKRIHEVQEEMKNKEQWDQL 1227

  Fly   753 PHTEREQHMTNLQHLGMLARFDNIIGRDTINLLKLLTSKIKSIFCHNSMVDRMAAMLNYFLLNLV 817
            |..:::...:.|.....::|....:..:|:::..|||.:::..|....:..|:|||||:.|..|.
Mouse  1228 PRDQQQARQSQLAQDERVSRSYLALATETVDMFHLLTKQVQKPFLRPELGPRLAAMLNFNLQQLC 1292

  Fly   818 GPKKERFKVKDKKEFEFDPAQTVIEISHIYINLSSDESFCLAVSQDGRSYSEQLFSYAENILIRI 882
            |||....||::.:::.|:|.:.:.:::.||:.|.. ..|..|::.|.||||::||   |.::.::
Mouse  1293 GPKCRDLKVENPEKYGFEPKKLLDQLTDIYLQLDC-ARFAKAIADDQRSYSKELF---EEVISKM 1353

  Fly   883 GGGQLIGDMSEFAVKVARMGAQYKEE-------QEL-LADAPEEYLDPIISTLMTDPVVLPSSKV 939
               :..|..|..|::..::.|:..||       .|: .:|||:|:.||::.|||||||.|||..|
Mouse  1354 ---RKAGIKSTIAIEKFKLLAEKVEEIVAKNARAEIDYSDAPDEFRDPLMDTLMTDPVRLPSGTV 1415

  Fly   940 TVDRSTIARHLLSDQTDPFNREPLTMDKVKSNEALKQEIESWIQGKREA 988
             :|||.|.||||:..||||||:.||...::....||::|::|::.|:.:
Mouse  1416 -MDRSIILRHLLNSPTDPFNRQMLTESMLEPVPELKEQIQAWMREKQSS 1463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11070	NP_609060.1	Ufd2P_core	251..898	CDD:287392	167/686 (24%)
CG11070	NP_609060.1	U-box	915..987	CDD:252675	37/71 (52%)
Ube4b	XP_036020183.1	PHA03247	<296..521	CDD:223021	1/4 (25%)
		Ufd2P_core	754..1374	CDD:402160	168/694 (24%)
		RING-Ubox_UBE4B	1387..1461	CDD:319572	37/74 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5113
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53881
OrthoDB	1	1.010	-	-		D194967at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1598
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.860