DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11070 and ube4a

DIOPT Version :9

Sequence 1:	NP_609060.1	Gene:	CG11070 / 33932	FlyBaseID:	FBgn0028467	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	XP_009290012.1	Gene:	ube4a / 557121	ZFINID:	ZDB-GENE-070410-21	Length:	1076	Species:	Danio rerio

Alignment Length:	1123	Identity:	356/1123 - (31%)
Similarity:	551/1123 - (49%)	Gaps:	201/1123 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SIEENPFAALLQEGA---------------------------------------NSDGVP----- 23
            :|.:||||||....|                                       |.|.|.
Zfish    10 NISQNPFAALFSSVADAKQFASDQKQQRPTEQQSVDSGESQSESENSASESIDENDDSVAEISRS 74

  Fly    24 -------------HKLVEEVLLFTLNKASSS---------AVLCLADVVVE-TSEEMLSEDLVAH 65
                         :.:::.:.|.||:.:..|         ..:.|.::..: ..::.|:.|.:..
Zfish    75 FRSRQELCEQLNVNHMIQRIFLITLDNSDPSLRSGNGIPPRCVYLEEMAADLDGQDWLNMDTIEQ 139

  Fly    66 ALFERLMLAETSQYAAG---------NASEMAMERRAMRYLKGAFTRCGLIQAERKID--CSKIL 119
            |||.||:|.|...:...         :|...|.|:||:.||...:.|     |:.:|.  ..|:|
Zfish   140 ALFNRLLLQEPGNHLIYMTSCSVVNLSADRDAGEKRAIPYLYACYQR-----AKEEITKVPEKLL 199

  Fly   120 A-------LILNNASTCMRQPDLFAPQSFGAQWMEM---------FEQDEDEHDTSTQEFLIRVT 168
            :       |.::||.|.:..|:::..|:...|.:::         ||:        ..|||..|.
Zfish   200 SFAVHCKNLTVSNARTVLLTPEIYISQNVYEQLLDLLLEAVRGAQFEE--------VVEFLEEVI 256

  Fly   169 CKVMEEVEPIEALGALKAIFYPVLTELQKNIAKLNLITMKKNTFW-ILGYFVRDKRAAVLGELLI 232
            ..::.:.| :...|   .:..||.......:..|:|..:...::. ||.||.|.|..|   ::|:
Zfish   257 ASLLADQE-VRTFG---EVMVPVFDIFHGRVKDLDLCQLLLFSYLEILLYFSRQKDIA---KVLM 314

  Fly   233 DYTTPNPRASGSEYMDTLLGSLLCISILPKTQ--TGKYEFF--------QELSINQTDEALWALL 287
            ::..|....:|.:|..||||::|.||.|.||.  ...:.||        |||.:.:::  :...:
Zfish   315 EHIQPKDPNNGIQYQKTLLGAILNISCLLKTPGVVENHGFFLNPSRSSPQELKVQESN--IHQFM 377

  Fly   288 SHHQQSIFLLVKQLLVLSPETKKKTLQWVGNCLDANVPRGHLWSSINASLEQTAHSTSSDAFMTN 352
            ......::.::|.||..|.||:...|.|:|.||.||:.|..:|:  |...|......:||||..|
Zfish   378 GQFHDKLYQILKNLLQQSGETRHLLLSWLGGCLQANMGRAKIWA--NQMPEIFFQMYASDAFFLN 440

  Fly   353 LTAVLVRLCAPLCMP-SLKVLLVDPTYC---AVPNKDRQAKGVSMLRAHAETCLLTSEEGEERLT 413
            |.|.|::||.|...| |.|:|..:||||   .:..::|:.:.|.......||||:.....:....
Zfish   441 LGAALLKLCQPFSRPYSPKLLTFNPTYCLLKELSEEERRNRNVHARGLDKETCLIPVPPQQTVEF 505

  Fly   414 AEKYNFVTEIFYMTHKCFELSNIPCIERFVRV---LRELQ----NTQMAYGEIVNSDPNSEVAKN 471
            |:.|:.:||...:|.....|......::.|::   |..||    :||::.|.....
Zfish   506 AQSYSLLTENLILTQLTLYLGFHRLHDQMVKMNQSLHRLQGTWRDTQLSGGPAAAE--------- 561

  Fly   472 LFRMIRDQIQQVLTIKNTLAEPTNDMYLLKFFEASAIWLTEIAMLPREIYEQCLDKRDFSPQVFR 536
                :|:|.:.::|:           ||          .|:.|.....:.:.||:.:.....:..
Zfish   562 ----LREQFEHLMTV-----------YL----------STKAATTQPTMLQNCLNLQASCAALLV 601

  Fly   537 NMELLSDTP-----PFVAPYMQS-----VPESIIDNISAFLNAARKLNGEQYINIYFSAHDAFFK 591
            .:.|.:..|     .|..|.:::     |||...:|:..|....|:. .::.:.....:.:....
Zfish   602 QLSLGNQGPEHIPLTFPLPSLENSLLCYVPEFFAENMGDFFIFLRRF-ADEVLESSAESLEHVLT 665

  Fly   592 MIILFMGSSALVKNPHLRAKLAEALEFLLP----------SRIMGSHRKTFVSHVFDNHPDRLKV 646
            .|.:.||:...:|||||||||||.||.::|          ..||...::.|.|:   .|..:|
Zfish   666 FITVLMGNVDRMKNPHLRAKLAEVLEAVMPHMETLSPGAAQPIMFQRQRVFSSY---RHAPQL-- 725

  Fly   647 VRSLLNVFVSIEMTGQSVQFEQKFNYRRPMYAIMEFLWTKPEHVQCFRDLAVEAEQNMDAIEPPI 711
            ..:|:.|||.||.||...|||||||||||||||::::|.:..:.:..::||..|.:|::|:.||:
Zfish   726 AEALITVFVDIEFTGDPHQFEQKFNYRRPMYAILKYMWGEKSYRESIKNLADYASENLEAMNPPL 790

  Fly   712 FLRFINLLINDAIFLLDESLSNLEQIKQLQQAQDNGEWESLPHTEREQHMTNLQHLGMLARFDNI 776
            ||||:|||:|||||||||::..|.:||.||..:|.|||:||....|.:..::||..|.|.||.||
Zfish   791 FLRFLNLLMNDAIFLLDEAIQYLSKIKILQLERDRGEWDSLAPDARREKESSLQMFGQLGRFHNI 855

  Fly   777 IGRDTINLLKLLTSKIKSIFCHNSMVDRMAAMLNYFLLNLVGPKKERFKVKDKKEFEFDPAQTVI 841
            :..:||..|..|||:||.:|.|..:.:|:.:||||||.:|||||....||||..||:|.|.|.|.
Zfish   856 MSNETIGTLAFLTSEIKGLFVHPFLAERIISMLNYFLQHLVGPKMGALKVKDFSEFDFKPQQLVS 920

  Fly   842 EISHIYINLSSDESFCLAVSQDGRSYSEQLFSYAENILIRIG-GGQLIGDMSEFAVKVARMGAQY 905
            :|..||:||..:|:||..|.:||||||..||.....:|.:|. .|.:|...|..|.|:..:..::
Zfish   921 DICTIYLNLGDEENFCATVPKDGRSYSPTLFCQTVRVLKKINKPGDMIISFSLLADKIKSLADRH 985

  Fly   906 KEEQELLADAPEEYLDPIISTLMTDPVVLPSSKVTVDRSTIARHLLSDQTDPFNREPLTMDKVKS 970
            ::|:|..:|||:|:||||:||||.|||:||||.||||||||||||||||||||||.|||||:::.
Zfish   986 QQEEETFSDAPDEFLDPIMSTLMLDPVLLPSSNVTVDRSTIARHLLSDQTDPFNRSPLTMDQIRP 1050

  Fly   971 NEALKQEIESWIQGKREA 988
            ||.|:|:|..|:...:::
Zfish  1051 NEELRQQIMKWLADHKQS 1068

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11070	NP_609060.1	Ufd2P_core	251..898	CDD:287392	232/688 (34%)
CG11070	NP_609060.1	U-box	915..987	CDD:252675	51/71 (72%)
ube4a	XP_009290012.1	UFD2	179..1075	CDD:227444	326/954 (34%)
		Ufd2P_core	333..978	CDD:287392	232/688 (34%)
		U-box	995..1067	CDD:252675	51/71 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581503
Domainoid	1	1.000	340	1.000	Domainoid score	I1061
eggNOG	1	0.900	-	-		E1_COG5113
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3517
Inparanoid	1	1.050	494	1.000	Inparanoid score	I1356
OMA	1	1.010	-	-		QHG53881
OrthoDB	1	1.010	-	-		D194967at2759
OrthoFinder	1	1.000	-	-		FOG0006865
OrthoInspector	1	1.000	-	-		oto39183
orthoMCL	1	0.900	-	-		OOG6_108713
Panther	1	1.100	-	-	LDO	PTHR13931
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1598
SonicParanoid	1	1.000	-	-		X4960
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800