DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11070 and CG9934

DIOPT Version :9

Sequence 1:	NP_609060.1	Gene:	CG11070 / 33932	FlyBaseID:	FBgn0028467	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_001162967.1	Gene:	CG9934 / 34699	FlyBaseID:	FBgn0032467	Length:	1217	Species:	Drosophila melanogaster

Alignment Length:	1129	Identity:	288/1129 - (25%)
Similarity:	479/1129 - (42%)	Gaps:	274/1129 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 NSDGVPHKLVEEVLLFTLNKASSSAVLC--------------------LADVVVET--------- 53
            ::|....:|:..:|..|.|:..|.:::|                    :|:|::|.
  Fly   200 SADEQNEQLLSRLLNATWNEYGSGSIICAQSASFLEQQPHRRFDFECIVANVLMEAVLKIYNGEL 264

  Fly    54 ----------------------SEEMLSEDLVAHALFERLMLA--ETSQYAAG-------NASEM 87
                                  |::...::::|:|:......|  ||:..|||       .:||.
  Fly   265 IEGDGVSVKADDKEFSSAKKIKSDDTEVQEILANAVATGGATASGETAAAAAGASGPIEATSSEA 329

  Fly    88 A--------------MERRAMRYLKGAFTRCGLIQAERKIDCSKILALILNNASTCMRQPDLFAP 138
            |              .:...:.||    .||   ....:.:||:         .|.:.||.|
  Fly   330 AGTCVAPPVLSIVATTKHHVLLYL----IRC---YQNYQTECSR---------KTPLTQPAL--- 375

  Fly   139 QSFGAQWMEM--------FEQDEDEH-DTS-----------TQEFLIRVTCKVMEEVEPIEALGA 183
            |....|.|.|        ..|:.:.| |.|           ::.|||.:.....::.|      |
  Fly   376 QLAFEQVMRMTVLVLTDRIYQNLNGHMDQSALLDLMYMAKVSEPFLIDLIAHTHQDRE------A 434

  Fly   184 LKAIFYPVLTEL----QKNI--AKLNLITMKKNTFWILGYFVRDKRAAVLGELLIDYTTPNP--- 239
            ...||..||..|    |:||  :|:::..::    | |...|..|..:|  ..:.|..:..|
  Fly   435 FDTIFSQVLRGLFAGMQRNICTSKISVQQIE----W-LSKLVVIKVGSV--RPIADLVSRQPNFL 492

  Fly   240 -----RASGSEYMD-TLLGSLLCISILPKTQTGKYEFFQELSINQTDEA-----LWALLSHHQQS 293
                 :.||.|.:. :.||..|.:|:..:......||..:   |:.::|     .|.|  |..::
  Fly   493 PPICTKISGREIVKCSFLGPFLSVSLFAEENIKFAEFTTK---NKLEDASSSRLRWEL--HSMRT 552

  Fly   294 IFLLVKQLLVLSPETKKKTLQWVGNCLDANVPRGHLWSSINASLEQTAHSTSSDAFMTNLTAVLV 358
            ...:|...|.::..::.|||:::.:.|..|..|...     ||.|:.   .:.|.||.||.:||.
  Fly   553 NMHVVFHSLCVNASSRPKTLEYIASILRHNDRRVQF-----ASDEKL---LARDGFMINLMSVLQ 609

  Fly   359 RLCAPLCMPSLKVLL--VDPTYCAVPNKDRQAKGVSMLRAHAETCLLTSEEGEERLTA------- 414
            :|       |:|:.|  ::|.:....|        |::....:|.:..|||......|
  Fly   610 QL-------SVKIKLDRIEPNFHYYKN--------SLVNIEQDTKIRYSEEEYRNFLARDFSQPV 659

  Fly   415 EKYNFVTEIFYMTHKCFELSNIPCIERF---VRVLRELQ-------NTQMAYGEIVNSDPNSEVA 469
            |..||.|:.:::|.:...|..:|.|:|:   ||.::|||       .|:..:.....::.|::..
  Fly   660 ENTNFQTQCWFLTLQAHHLGYLPAIQRYRQKVRAIKELQKLIDELDRTKSHWMNSRYANRNNQFK 724

  Fly   470 KNLFRMIRDQIQQVLTIKNTLAEP-----------TNDMYLLKFFEASAIWLTEIAMLPREIYEQ 523
            :...:.:|...:.....:.||.:|           |...::|..||...|....|:.||   .:|
  Fly   725 ERWEKQLRKLNRSKTCCEITLLDPGLLQRCTEFYSTVCEFMLYQFEGRPIEGPFISKLP---VQQ 786

  Fly   524 CLDKRDFSPQVFRNMELLSDTPPFVAPYMQSVPESIIDNISAFLNAARKLNGEQYIN--IYFSAH 586
            .|....||                      ::||..||:|:.|:     |...|:.|  |.....
  Fly   787 LLPTDAFS----------------------ALPEWYIDDIAEFI-----LFTMQHANMDIRQGID 824

  Fly   587 DAFFKMIILFMGSSALVKNPHLRAKLAEALEFLLPSRIMGSHRKTFVSHVFDNHPDRLKVVRSLL 651
            .:....::..:.:|.|:|||::.|||.|.: |:...:...|......:|....:    .:|.||:
  Fly   825 HSIITWLLTCVCASHLIKNPYVTAKLVEVM-FVFSLKPANSVNAAMWNHELAQN----ALVSSLM 884

  Fly   652 NVFVSIEMTGQSVQFEQKFNYRRPMYAIMEFLWTKPEHVQCFRDLAVEAEQNMDAIEPPIFLRFI 716
            ..:|.:|.||||.:|..||..|..:..:.:.:|..|.|.|     ||..|..:.    ..|::|:
  Fly   885 RFYVDVETTGQSTEFYDKFTIRYHISHLFKSMWENPIHRQ-----AVICESRVG----NQFVKFV 940

  Fly   717 NLLINDAIFLLDESLSNLEQIKQLQQ-AQDNGEWESLPHTEREQHMTNLQHLGMLARFDNIIGRD 780
            |:|:||..|||||.|.||::|.|.|| ..|......:...:::..:|.|.......|....:.|:
  Fly   941 NMLMNDTTFLLDECLENLKRIHQTQQLLSDKANLSKMSAEQQQSRLTQLATDERQCRSYLTLARE 1005

  Fly   781 TINLLKLLTSKIKSIFCHNSMVDRMAAMLNYFLLNLVGPKKERFKVKDKKEFEFDPAQTVIEISH 845
            |::|...|||.||..|..:.:|||:::|||:.|..|.|||....|||:..::.::|...:.:|..
  Fly  1006 TVDLFHYLTSDIKEPFMRDELVDRLSSMLNFNLKQLAGPKCNDLKVKNPAKYGWEPRSLLAQIFD 1070

  Fly   846 IYINLSSDESFCLAVSQDGRSYSEQLFSYAENILIRIGGGQLIGDMSEFAVKVARMGAQYKEEQE 910
            ||::|..|. |..|::.|.||:..|:.:.|.:.:.|:.        ...||:|.|..|..:...|
  Fly  1071 IYLHLDCDR-FAEALAADERSFDVQICNEAASRIKRLA--------LRSAVEVERFKALTQRAHE 1126

  Fly   911 L----------LADAPEEYLDPIISTLMTDPVVLPSSKVTVDRSTIARHLLSDQTDPFNREPLTM 965
            :          .||||:|:.||::.|||:|||||||..| :||:.|.||||:..||||||:|||.
  Fly  1127 IYVTNLQTEDECADAPDEFKDPLMDTLMSDPVVLPSGTV-MDRAIITRHLLNSCTDPFNRQPLTE 1190

  Fly   966 DKVKSNEALKQEIESW---IQGKR 986
            |.:.:|..|||.|::|   .:|||
  Fly  1191 DMLVANIELKQRIDAWRKEQRGKR 1214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11070	NP_609060.1	Ufd2P_core	251..898	CDD:287392	176/684 (26%)
CG11070	NP_609060.1	U-box	915..987	CDD:252675	42/75 (56%)
CG9934	NP_001162967.1	Ufd2P_core	510..1124	CDD:287392	179/694 (26%)
CG9934	NP_001162967.1	U-box	1141..1211	CDD:252675	39/70 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449865
Domainoid	1	1.000	79	1.000	Domainoid score	I3030
eggNOG	1	0.900	-	-		E1_COG5113
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D194967at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR13931
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1598
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.880