Protein Alignment Ube4A and ufd-2

DIOPT Version :10

• Sequence 1: NP_609060.1
• Gene: Ube4A / 33932
• FlyBaseID: FBgn0028467
• Length: 993
• Species: Drosophila melanogaster
• Sequence 2: NP_495691.1
• Gene: ufd-2 / 174295
• WormBaseID: WBGene00006734
• Length: 984
• Species: Caenorhabditis elegans
• Alignment Length: 917
• Identity: 217/917 - (23%)
• Similarity: 384/917 - (41%)
• Gaps: 206/917 - (22%)

  Fly   152 DEDEHDTSTQEF-----LIR--VTCKVMEEVEPIEALGALKAIFYPVLTELQKNIAK-LNLITMK 208
            ||.:.|..|:.|     ::|  :.|:..|:.:                .|:.:.|.: :||
 Worm   196 DECDEDAITETFNPIFGILRSGIICQRFEDNK----------------DEIVRQILRVMNL---- 240

  Fly   209 KNTFWILGYFVRDKRAAVLGELLID----YTTPNPRASGSEY-MDTLLGSLLCISILPKTQTGKY 268
                 :|...:.......|..||::    ..||:.:..|.|: :.:.||......:....:...:
 Worm   241 -----LLSIRLPSNGPRPLSNLLVNREDFLPTPSEKIQGREFGLMSFLGPFFSYGLESSARRPNH 300

  Fly   269 EFFQEL---------SINQTDEALWALLSHHQQSIFLLVKQLLV-LSPE--TKKKTLQWVGNCLD 321
            ..|.:.         |:| |::.|:   ......|..::.||:: |:.:  ::.|||:|:...:.
 Worm   301 RVFVDCEEDARKYDGSVN-TEQKLY---FQRMDPIRTMLHQLMLPLASDQGSRNKTLRWIATIIS 361

  Fly   322 ANVPRGHLWSSINASLEQTAHSTSSDA----FMTNLTAVLVRLCAPLCMPSLKVLLVDPTYCAVP 382
            .|            .:...:|...||.    :|||..:|:......:   .|..::||  |..:|
 Worm   362 TN------------DIRTRSHYDPSDVLCDHYMTNFLSVMYMFSEKI---DLSKIIVD--YPFLP 409

  Fly   383 NKDRQAKGVSMLRAHAETCLLTSEEGEERLTA------EKYNFVTEIFYMTHKCFELSNIPC--- 438
            :        |::....||.|...|.|.....:      ::|:|.|..|::|.....|...|.
 Worm   410 S--------SLINISKETRLKMDESGAVAFASQFADRPDEYHFSTVCFFLTIAAQRLVIPPLMNQ 466

  Fly   439 IERFVRVLRELQNTQMAYGEIVNS---DPNSEVAKNL------FRMIRDQIQQVLTIKNTLAEPT 494
            |..:.|.|:||::...|..|.:|:   ...:||.|.|      ::::.   :.:|.:|....:|.
 Worm   467 ISEYSRHLKELKHKINALKEKLNTVSGFERAEVEKKLNYETEHWKLMS---RHLLCVKTQAQDPA 528

  Fly   495 NDMYLLKFFEASAIWLTEIAMLPREIYEQCLDKRDFSPQVFRNMELLSD---TPPFVAPYMQSVP 556
            .....:.|.:....::..:                    :..|::||.|   .|..|:....::|
 Worm   529 LMASSMDFVDKQMKFILNL--------------------LCDNLDLLGDDSQLPTEVSQMFCALP 573

  Fly   557 ESIIDNISAF----LNAARKLNGEQYINIYFSAHDAFFKMIILFMGSSALVKNPHLRAKLAEALE 617
            |..:::...|    ::...||..|:..       |...::.:||. ....:|:|.|.:||...|.
 Worm   574 EYFLEDALDFYIFAISNGMKLLMERNA-------DWISRLTVLFT-QYHYIKSPFLVSKLVRVLS 630

  Fly   618 FLLPSRIMGSHRKTFVSHVFDNHPDRLKVVR----------SLLNVFVSIEMTGQSVQFEQKFNY 672
            .:.|                   |....|||          .::..:...|..|   .|.:|||.
 Worm   631 SIQP-------------------PLWFNVVRLRMAQENLLMCMIKFYSDFEDNG---DFYEKFNV 673

  Fly   673 RRPMYAIMEFLWTKPEHVQCFRDLAVE--AEQNMDAIEPPIFLRFINLLINDAIFLLDESLSNLE 735
            |..:..::|.:.....:...|.|:|.|  ||          |:||:|::||||.:.:|||||.|:
 Worm   674 RGNIQYMLEKMEEDMFYKGKFMDMARECGAE----------FIRFVNMVINDATWCIDESLSGLK 728

  Fly   736 QIKQLQQAQDNG-EWESLPHTEREQHMTNLQHLGML----ARFDNIIGRDTINLLKLLTSKIKS- 794
            .|..:::...|. ||::     .:|.:.| |.||:.    .:....:|....||..||:..:.|
 Worm   729 SIHDVEKKMANKVEWDN-----TDQEIRN-QDLGVYEEAKRKVKGWLGTAKSNLKLLLSITVNSP 787

  Fly   795 -IFCHNSMVDRMAAMLNYFLLNLVGPKKERFKVKDKKEFEFDPAQTVIEISHIYINLSSDESFCL 858
             .|....:.:|:|||||:.|..|:|.|....||||.:.:.::|.:.|..:..||:.|:. .:|..
 Worm   788 EPFRTPVLGERLAAMLNHNLSQLIGSKASELKVKDPRSYGWEPREFVSLLISIYLKLNM-PAFVK 851

  Fly   859 AVSQDGRSYSEQLFSYAENILIR---IGGGQL--IGDMSEFAVKVARMGAQYKEEQELLADAPEE 918
            .::.|.|:||.:.|..|...:.:   :|..||  ...::|...|.....|:.:||.:   |.|||
 Worm   852 YIAYDERTYSPEFFHNAIECMRKNSIVGFSQLESFEHLAEDVKKEYEAKAELEEEYD---DVPEE 913

  Fly   919 YLDPIISTLMTDPVVLPSSKVTVDRSTIARHLLSDQTDPFNREPLTMDKVKSNEALKQEIESWIQ 983
            :.|||:..:|.|||.|||..| :||:.|.|||||...:||||.||:.:::..:..||.:|:.||.
 Worm   914 FKDPIMDAIMVDPVKLPSGHV-MDRAVIERHLLSTPNNPFNRAPLSHNELSPDSELKAKIQEWIC 977

  Fly   984 GKREAAR 990
            .||.:.:
 Worm   978 QKRNSKK 984

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ube4A	NP_609060.1	Ufd2P_core	251..898	CDD:463080	157/711 (22%)
		RING-Ubox_UBE4A	917..986	CDD:438319	32/68 (47%)
ufd-2	NP_495691.1	Ufd2P_core	283..893	CDD:463080	157/708 (22%)
		RING-Ubox_UBE4B	907..980	CDD:438320	34/76 (45%)