DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11070 and ufd-2

DIOPT Version :9

Sequence 1:	NP_609060.1	Gene:	CG11070 / 33932	FlyBaseID:	FBgn0028467	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_495691.1	Gene:	ufd-2 / 174295	WormBaseID:	WBGene00006734	Length:	984	Species:	Caenorhabditis elegans

Alignment Length:	917	Identity:	217/917 - (23%)
Similarity:	384/917 - (41%)	Gaps:	206/917 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 DEDEHDTSTQEF-----LIR--VTCKVMEEVEPIEALGALKAIFYPVLTELQKNIAK-LNLITMK 208
            ||.:.|..|:.|     ::|  :.|:..|:.:                .|:.:.|.: :||
Worm   196 DECDEDAITETFNPIFGILRSGIICQRFEDNK----------------DEIVRQILRVMNL---- 240

  Fly   209 KNTFWILGYFVRDKRAAVLGELLID----YTTPNPRASGSEY-MDTLLGSLLCISILPKTQTGKY 268
                 :|...:.......|..||::    ..||:.:..|.|: :.:.||......:....:...:
Worm   241 -----LLSIRLPSNGPRPLSNLLVNREDFLPTPSEKIQGREFGLMSFLGPFFSYGLESSARRPNH 300

  Fly   269 EFFQEL---------SINQTDEALWALLSHHQQSIFLLVKQLLV-LSPE--TKKKTLQWVGNCLD 321
            ..|.:.         |:| |::.|:   ......|..::.||:: |:.:  ::.|||:|:...:.
Worm   301 RVFVDCEEDARKYDGSVN-TEQKLY---FQRMDPIRTMLHQLMLPLASDQGSRNKTLRWIATIIS 361

  Fly   322 ANVPRGHLWSSINASLEQTAHSTSSDA----FMTNLTAVLVRLCAPLCMPSLKVLLVDPTYCAVP 382
            .|            .:...:|...||.    :|||..:|:......:   .|..::||  |..:|
Worm   362 TN------------DIRTRSHYDPSDVLCDHYMTNFLSVMYMFSEKI---DLSKIIVD--YPFLP 409

  Fly   383 NKDRQAKGVSMLRAHAETCLLTSEEGEERLTA------EKYNFVTEIFYMTHKCFELSNIPC--- 438
            :        |::....||.|...|.|.....:      ::|:|.|..|::|.....|...|.
Worm   410 S--------SLINISKETRLKMDESGAVAFASQFADRPDEYHFSTVCFFLTIAAQRLVIPPLMNQ 466

  Fly   439 IERFVRVLRELQNTQMAYGEIVNS---DPNSEVAKNL------FRMIRDQIQQVLTIKNTLAEPT 494
            |..:.|.|:||::...|..|.:|:   ...:||.|.|      ::::.   :.:|.:|....:|.
Worm   467 ISEYSRHLKELKHKINALKEKLNTVSGFERAEVEKKLNYETEHWKLMS---RHLLCVKTQAQDPA 528

  Fly   495 NDMYLLKFFEASAIWLTEIAMLPREIYEQCLDKRDFSPQVFRNMELLSD---TPPFVAPYMQSVP 556
            .....:.|.:....::..:                    :..|::||.|   .|..|:....::|
Worm   529 LMASSMDFVDKQMKFILNL--------------------LCDNLDLLGDDSQLPTEVSQMFCALP 573

  Fly   557 ESIIDNISAF----LNAARKLNGEQYINIYFSAHDAFFKMIILFMGSSALVKNPHLRAKLAEALE 617
            |..:::...|    ::...||..|:..       |...::.:||. ....:|:|.|.:||...|.
Worm   574 EYFLEDALDFYIFAISNGMKLLMERNA-------DWISRLTVLFT-QYHYIKSPFLVSKLVRVLS 630

  Fly   618 FLLPSRIMGSHRKTFVSHVFDNHPDRLKVVR----------SLLNVFVSIEMTGQSVQFEQKFNY 672
            .:.|                   |....|||          .::..:...|..|   .|.:|||.
Worm   631 SIQP-------------------PLWFNVVRLRMAQENLLMCMIKFYSDFEDNG---DFYEKFNV 673

  Fly   673 RRPMYAIMEFLWTKPEHVQCFRDLAVE--AEQNMDAIEPPIFLRFINLLINDAIFLLDESLSNLE 735
            |..:..::|.:.....:...|.|:|.|  ||          |:||:|::||||.:.:|||||.|:
Worm   674 RGNIQYMLEKMEEDMFYKGKFMDMARECGAE----------FIRFVNMVINDATWCIDESLSGLK 728

  Fly   736 QIKQLQQAQDNG-EWESLPHTEREQHMTNLQHLGML----ARFDNIIGRDTINLLKLLTSKIKS- 794
            .|..:::...|. ||::     .:|.:.| |.||:.    .:....:|....||..||:..:.|
Worm   729 SIHDVEKKMANKVEWDN-----TDQEIRN-QDLGVYEEAKRKVKGWLGTAKSNLKLLLSITVNSP 787

  Fly   795 -IFCHNSMVDRMAAMLNYFLLNLVGPKKERFKVKDKKEFEFDPAQTVIEISHIYINLSSDESFCL 858
             .|....:.:|:|||||:.|..|:|.|....||||.:.:.::|.:.|..:..||:.|:. .:|..
Worm   788 EPFRTPVLGERLAAMLNHNLSQLIGSKASELKVKDPRSYGWEPREFVSLLISIYLKLNM-PAFVK 851

  Fly   859 AVSQDGRSYSEQLFSYAENILIR---IGGGQL--IGDMSEFAVKVARMGAQYKEEQELLADAPEE 918
            .::.|.|:||.:.|..|...:.:   :|..||  ...::|...|.....|:.:||.:   |.|||
Worm   852 YIAYDERTYSPEFFHNAIECMRKNSIVGFSQLESFEHLAEDVKKEYEAKAELEEEYD---DVPEE 913

  Fly   919 YLDPIISTLMTDPVVLPSSKVTVDRSTIARHLLSDQTDPFNREPLTMDKVKSNEALKQEIESWIQ 983
            :.|||:..:|.|||.|||..| :||:.|.|||||...:||||.||:.:::..:..||.:|:.||.
Worm   914 FKDPIMDAIMVDPVKLPSGHV-MDRAVIERHLLSTPNNPFNRAPLSHNELSPDSELKAKIQEWIC 977

  Fly   984 GKREAAR 990
            .||.:.:
Worm   978 QKRNSKK 984

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11070	NP_609060.1	Ufd2P_core	251..898	CDD:287392	157/711 (22%)
CG11070	NP_609060.1	U-box	915..987	CDD:252675	34/71 (48%)
ufd-2	NP_495691.1	Ufd2P_core	283..893	CDD:313606	157/708 (22%)
		RING-Ubox_UBE4B	906..980	CDD:319572	35/77 (45%)
		U-box domain, a modified RING finger	916..953	CDD:319572	20/37 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53881
OrthoDB	1	1.010	-	-		D194967at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1598
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.960