DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11070 and ube4b

DIOPT Version :9

Sequence 1:	NP_609060.1	Gene:	CG11070 / 33932	FlyBaseID:	FBgn0028467	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	XP_021325394.1	Gene:	ube4b / 170784	ZFINID:	ZDB-GENE-020205-1	Length:	1349	Species:	Danio rerio

Alignment Length:	1078	Identity:	270/1078 - (25%)
Similarity:	462/1078 - (42%)	Gaps:	234/1078 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GVPHKLVEEVLLFTLNKASSSAVL---CLADVVVETSEEMLSEDLVAHALFERLMLAETSQYAAG 82
            |.|..:.....|.|...:||...|   .|:|:..::|:|...|:  ....|..:....:...:||
Zfish   390 GSPTTMARRTALATRMPSSSPFSLLFFALSDLPQDSSDEEQEEE--GEEDFSGVQFGSSLGASAG 452

  Fly    83 NAS----------EMAMERRAMRYLKGAFTRCGLIQAERKI------------------DCSKIL 119
            ..:          |...|...:.||...|...|:  .|||.                  .|....
Zfish   453 GMAGDSGSDRFTIESCKETEMLNYLIERFDSVGM--EERKAPKMCSQPAVSQLLSNIRSQCISHA 515

  Fly   120 ALILNNASTCMR---QPDLFA--------PQSFGAQWMEMFEQDEDEHDTSTQEFLIRVTCKVME 173
            ||:|..|.|..|   ||.|..        |..|..:.:.|..|:||
Zfish   516 ALVLQGALTQPRAPLQPSLLVPYMLCRNLPYGFIQELVRMTHQEED------------------- 561

  Fly   174 EVEPIEALGALKAIFYPVLTELQKNIAKLNLITMKKNTFWILGYFVRDKRAAVLGELLIDYT--- 235
                     ..|.||.|:|..|        .:.:|:.:|....:.......|.|.|:....|
Zfish   562 ---------VFKQIFVPILQGL--------ALAVKECSFDSDNFKFPLMALAELCEIKFGKTHPV 609

  Fly   236 ----------TPNPRA--SGSEYMD-TLLGSLLCISILPKTQT---GKYEFFQELSINQTDEALW 284
                      .|:|.:  :|.|... :.||:...:|:..:..|   .||.....:::..| ..:.
Zfish   610 CNLITSLPLWCPDPLSPGTGREIQRLSFLGAFFSLSVFAEDDTKVGDKYFSGPAITMENT-RVVS 673

  Fly   285 ALLSHHQQS----IFLLVKQLLVLSPETKKKTLQWVGNCLDANVPRGHLWSSINASLEQTAHSTS 345
            ..|.|:.:|    :|.::..:| |:.||::..|.::...::.||.:        |.::......|
Zfish   674 QSLQHYLESARGDLFKILHNIL-LNGETREAALSYMAALVNRNVKK--------AQMQTDDKLVS 729

  Fly   346 SDAFMTNLTAVLVRLCAPLCMPSLKVLL--VDPTYCAVPNKDRQAKGVSMLRAHAETCLLTSEEG 408
            :|.||.|...||.:|       |:|:.|  |||.|...|.                 |.|.....
Zfish   730 TDGFMMNFLWVLQQL-------SMKIKLETVDPLYIFHPK-----------------CRLNVSPE 770

  Fly   409 EERLTA----------------EKYN---FVTEIFYMTHKCFELSNIPCIERFVRVLRELQNTQM 454
            |.||.|                .|::   |.||.|::|.....||.:||..|::|.||.:::...
Zfish   771 ETRLKATMEELKSWLTELHEDPTKFSEPKFPTECFFLTLHAHHLSILPCCRRYIRRLRAIRDLNR 835

  Fly   455 AYGEIVNSD---PNSEVA---KNLFRMIRDQIQQVLTIKNTLAEPTNDMYLLKFFEASAIWLTEI 513
            ...|:.||:   .:|.:|   :.:.:..:.|:::::..|                 |.|    :.
Zfish   836 TVEELKNSENQWKDSPLAGRHREMLKRCKTQLKKLVRSK-----------------ACA----DA 879

  Fly   514 AMLPREIYEQCLDKRDFSPQVFRNMELLSDTPPFVA-PYMQSVPESI-------IDNISAFLNAA 570
            .:|...:..:||  :.||..:...:.::....|.|: |....:|:|.       |::::.|:
Zfish   880 GLLDENLLRRCL--QFFSMVIQLILRMVEPAFPHVSLPLNPEIPKSFAALPEFYIEDVAEFM--- 939

  Fly   571 RKLNGEQYIN--IYFSAHDAFFKMIILFMGSSALVKNPHLRAKLAEALEFLLPSRIMGSHRKTFV 633
              |...||..  :|....:.....:|:|:.|...:|||:|.|||.|.| |:....:....::.|
Zfish   940 --LFIVQYFPQVLYEPCTEDIVTFLIVFICSQNYIKNPYLIAKLVEVL-FVTNPAVQPRTQRFF- 1000

  Fly   634 SHVFDNHPDRL-KVVRSLLNVFVSIEMTGQSVQFEQKFNYRRPMYAIMEFLWTKPEHVQCFRDLA 697
             .:.:|||..: ::|.:|:..:..:|.||.:.:|..||..|..:..|.:.||....|...|.:..
Zfish  1001 -EMLENHPLSVNQLVPALMKFYTDVEHTGATSEFYDKFTIRYHISTIFKSLWQNINHQGTFLEEF 1064

  Fly   698 VEAEQNMDAIEPPIFLRFINLLINDAIFLLDESLSNLEQIKQLQQAQDNGE-WESLPHTEREQHM 761
            ...:|         |:|:||:||||..|||||||.:|::|.::|:...|.| |:.||..:::...
Zfish  1065 NSGKQ---------FVRYINMLINDTTFLLDESLESLKRIHEIQEEMKNKEQWDLLPREQQQSRQ 1120

  Fly   762 TNLQHLGMLARFDNIIGRDTINLLKLLTSKIKSIFCHNSMVDRMAAMLNYFLLNLVGPKKERFKV 826
            :.|.....::|....:..:|:::..:||.:::..|....:..|:||||||.|..|.|||....||
Zfish  1121 SQLTQDERVSRSYLALATETVDMFHILTKQVQKPFLRPELGPRLAAMLNYNLQQLCGPKCRDLKV 1185

  Fly   827 KDKKEFEFDPAQTVIEISHIYINLSSDESFCLAVSQDGRSYSEQLFSYAENILIRIGGGQLIGDM 891
            ::.:::.|:|.:.:.:::.||:.|.... |..|::.|.||||.:||   |.::.::   :..|..
Zfish  1186 ENPEKYGFEPKKLLDQLTDIYLQLDCPR-FAKAIADDQRSYSRELF---EEVISKM---RKAGIK 1243

  Fly   892 SEFAV--------KVARMGAQYKEEQELLADAPEEYLDPIISTLMTDPVVLPSSKVTVDRSTIAR 948
            |..|:        ||..:.|:..:.:...:|||:|:.||::.|||||||.|||..: :|||.|.|
Zfish  1244 STIAIEKFKLLLEKVEEIVARNSQSEMDYSDAPDEFKDPLMDTLMTDPVQLPSGNI-MDRSIILR 1307

  Fly   949 HLLSDQTDPFNREPLTMDKVKSNEALKQEIESWIQGKR 986
            |||:..||||||:|||...::....||:.|::|::.|:
Zfish  1308 HLLNSPTDPFNRQPLTESMLEPVPELKERIQAWMREKQ 1345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11070	NP_609060.1	Ufd2P_core	251..898	CDD:287392	173/700 (25%)
CG11070	NP_609060.1	U-box	915..987	CDD:252675	37/72 (51%)
ube4b	XP_021325394.1	Atrophin-1	<239..413	CDD:331285	6/22 (27%)
		Ufd2P_core	638..1258	CDD:313606	173/700 (25%)
		RING-Ubox_UBE4B	1271..1345	CDD:319572	37/74 (50%)
		U-box domain, a modified RING finger	1281..1318	CDD:319572	23/37 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5113
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53881
OrthoDB	1	1.010	-	-		D194967at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1598
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.860