DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11070 and Ube4a

DIOPT Version :9

Sequence 1:	NP_609060.1	Gene:	CG11070 / 33932	FlyBaseID:	FBgn0028467	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	NP_001333627.1	Gene:	Ube4a / 140630	MGIID:	2154580	Length:	1085	Species:	Mus musculus

Alignment Length:	1039	Identity:	372/1039 - (35%)
Similarity:	539/1039 - (51%)	Gaps:	119/1039 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 QEGANSDGVPHKLVEEVLLFTLNKAS---------SSAVLCLADVVVE-TSEEMLSEDLVAHALF 68
            ||......:.| :::.:.|.||:.:.         .|..:.|.::.|| ..::.|....|..|:|
Mouse    95 QEMCEQLNINH-MIQRIFLITLDNSDPSLKSGNGIPSRCVYLEEMAVELEDQDWLDMSNVEQAIF 158

  Fly    69 ERLMLAETSQYAAG---------NASEMAMERRAMRYLKGAFTRCGLIQAERKIDCSKI------ 118
            .||:|.:...:...         :|...|.||....||...|.|.       |.:.:|:
Mouse   159 ARLLLQDPGNHLISMTSSTTLNLSADRDAGERHIFCYLYSCFQRA-------KEEITKVPENLLP 216

  Fly   119 -----LALILNNASTCMRQPDLFAPQSFGAQWME-MFEQDEDEHDTSTQEFLIRVTCKVMEEVEP 177
                 ..|.::|..|.:..|:::..|:...|.:: |.|..:..|.....|||        |||
Mouse   217 FAVQCRNLTVSNTRTVLLTPEIYVDQNIHEQLVDLMLEAIQGAHFEDVTEFL--------EEV-- 271

  Fly   178 IEAL------GALKAIFYPVLTELQKNIAKLNLITMKKNTFW-ILGYFVRDKRAAVLGELLIDYT 235
            ||||      .....:..||...|...|..|.|..:....:. ||.||.|.|..|   ::.::|.
Mouse   272 IEALLLDEEVRTFPEVMIPVFDILLSRIKDLELCQILLYAYLDILLYFTRQKDMA---KVFLEYI 333

  Fly   236 TPNPRASGSEYMDTLLGSLLCISILPKTQ--TGKYEFF--------QELSINQTDEALWALLSHH 290
            .|...::|..|..||||.:|.||.|.||.  ...:.||        ||:.:.:.:  :...::..
Mouse   334 QPKDPSNGQMYQKTLLGVILNISCLLKTPGVVENHGFFLNPSRSSPQEIKVQEAN--IHQFMAQF 396

  Fly   291 QQSIFLLVKQLLVLSPETKKKTLQWVGNCLDANVPRGHLWSSINASLEQTAHSTSSDAFMTNLTA 355
            .:.|:.::|.||.||||||...|.|:||||.||..|..:|:  |...|......:||||..||.|
Mouse   397 HEKIYQMLKNLLQLSPETKHCILFWLGNCLHANAGRTKIWA--NQMPEIFFQMYASDAFFLNLGA 459

  Fly   356 VLVRLCAPLCMP-SLKVLLVDPTYCAVP---NKDRQAKGVSMLRAHAETCLLTSEEGEERLTAEK 416
            .|::||.|.|.| |.::|..:||||.:.   :::|:.|.|.|.....||||:.:.  :|....:.
Mouse   460 ALLKLCQPFCKPRSSRLLTFNPTYCVLKDLNDEERKIKSVHMRGLDKETCLIPAV--QEPTFPQS 522

  Fly   417 YNFVTEIFYMTHKCFELSNIPCIERFVRVLRELQNTQMAYGEIVNSDPNSEVAKNLFRMIRDQIQ 481
            ||.|||...:|.....|......::.|::.:.|...|:|:.:...|  :|..|.||    |:|.:
Mouse   523 YNLVTENLALTEYTLYLGFHRLHDQMVKINQNLHRLQVAWRDAQQS--SSPAADNL----REQFE 581

  Fly   482 QVLTI----KNTLAEPTNDMYLLKFFEASAIWLTEIAMLPREIYEQCLDKRDFSPQVFRNMELLS 542
            :::||    |..:.||......|....:.|:.|.::|          :......|     :||..
Mouse   582 RLMTIYLSTKTAMTEPQMLQNCLNLQVSMAVLLVQLA----------IGNEGSQP-----IELSF 631

  Fly   543 DTPPFVAPYMQSVPESIIDNISAFLNAARKLNGEQYINIYFSAHDAFFKMIILFMGSSALVKNPH 607
            ..|...:. :..|||...||:..||...|:. .|..:.....:.:.....|.:|.||...:||||
Mouse   632 PLPDGYSS-LAYVPEFFADNLGDFLIFLRRF-AEDILETSADSLEHVLHFITIFTGSIERMKNPH 694

  Fly   608 LRAKLAEALEFLL------PSRIMGS--HRKTFVSHVFDNHPDRLKVVRSLLNVFVSIEMTGQSV 664
            |||||||.||.::      ||.::.|  |||    .||.|.|...::..:|:.|||.||.||...
Mouse   695 LRAKLAEVLEAVMPHLDQTPSPLVSSVFHRK----RVFCNFPYAPQLAEALIKVFVDIEFTGDPH 755

  Fly   665 QFEQKFNYRRPMYAIMEFLWTKPEHVQCFRDLAVEAEQNMDAIEPPIFLRFINLLINDAIFLLDE 729
            |||||||||||||.|:.::|....:.:..:|||..|.:|::|:.||:||||:|||:|||||||||
Mouse   756 QFEQKFNYRRPMYPILRYMWGTDCYRESIKDLADYASKNLEAMNPPLFLRFLNLLMNDAIFLLDE 820

  Fly   730 SLSNLEQIKQLQQAQDNGEWESLPHTEREQHMTNLQHLGMLARFDNIIGRDTINLLKLLTSKIKS 794
            ::..|.:||..|..:|.||||||....|.:....||..|.||||.||:..:||..|..|||:|||
Mouse   821 AIQYLSKIKIQQIEKDRGEWESLTPEARREKEAGLQMFGQLARFHNIMSNETIGTLSFLTSEIKS 885

  Fly   795 IFCHNSMVDRMAAMLNYFLLNLVGPKKERFKVKDKKEFEFDPAQTVIEISHIYINLSSDESFCLA 859
            :|.|..:.:|:.:||||||.:|||||....||||..||:|.|.|.|.:|..||:||..:|:||..
Mouse   886 LFVHPFLAERIISMLNYFLQHLVGPKMGALKVKDFSEFDFKPQQLVSDICTIYLNLGDEENFCAT 950

  Fly   860 VSQDGRSYSEQLFSYAENILIRIG-GGQLIGDMSEFAVKVARMGAQYKEEQELLADAPEEYLDPI 923
            |.:||||||..||:....:|.:|. .|.:|...|..|.::..:....::|:|..|||.:|:||||
Mouse   951 VPKDGRSYSPTLFAQTVRVLKKINKPGNMIVAFSNLAERIKSLADLQQQEEETYADACDEFLDPI 1015

  Fly   924 ISTLMTDPVVLPSSKVTVDRSTIARHLLSDQTDPFNREPLTMDKVKSNEALKQEIESWIQGKRE 987
            :||||:||||||||:||||||||||||||||||||||.|||||:::.|..||::|:.|:..:::
Mouse  1016 MSTLMSDPVVLPSSRVTVDRSTIARHLLSDQTDPFNRSPLTMDQIRPNTELKEKIQRWLAERKQ 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11070	NP_609060.1	Ufd2P_core	251..898	CDD:287392	253/673 (38%)
CG11070	NP_609060.1	U-box	915..987	CDD:252675	50/71 (70%)
Ube4a	NP_001333627.1	Ufd2P_core	349..990	CDD:371035	253/673 (38%)
		RING-Ubox_UBE4A	1009..1078	CDD:319571	49/68 (72%)
		U-box domain, a modified RING finger	1013..1051	CDD:319571	34/37 (92%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837759
Domainoid	1	1.000	191	1.000	Domainoid score	I3243
eggNOG	1	0.900	-	-		E1_COG5113
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3517
Inparanoid	1	1.050	466	1.000	Inparanoid score	I1525
Isobase	1	0.950	-	0	Normalized mean entropy	S3949
OMA	1	1.010	-	-		QHG53881
OrthoDB	1	1.010	-	-		D194967at2759
OrthoFinder	1	1.000	-	-		FOG0006865
OrthoInspector	1	1.000	-	-		oto93615
orthoMCL	1	0.900	-	-		OOG6_108713
Panther	1	1.100	-	-	LDO	PTHR13931
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1598
SonicParanoid	1	1.000	-	-		X4960
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750