DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11070 and ube4b

DIOPT Version :9

Sequence 1:	NP_609060.1	Gene:	CG11070 / 33932	FlyBaseID:	FBgn0028467	Length:	993	Species:	Drosophila melanogaster
Sequence 2:	XP_031762209.1	Gene:	ube4b / 100491174	XenbaseID:	XB-GENE-6037352	Length:	1331	Species:	Xenopus tropicalis

Alignment Length:	1041	Identity:	262/1041 - (25%)
Similarity:	461/1041 - (44%)	Gaps:	193/1041 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 TLNKASSSAVLCLADVVVETSEEMLSEDLVAHALFERLMLAETSQYAAGNASEMAMERRAMRYLK 98
            |.:...|...|...|....:|:|...|:..:...|.....:.|...|.....|...|...:.||.
Frog   396 TYDSHMSLLSLTCPDEAEGSSDEENHEEEFSCVQFGSSATSSTESCADHFTIETCKETEMLNYLI 460

  Fly    99 GAFTRCGLIQAERKI-------DCSKIL-----------ALILNNAST---CMRQPDLFAPQ--- 139
            ..|.|.|:  .|||.       |.|::|           ||:|..|.|   .::||.|..|.
Frog   461 ECFDRVGI--EERKAPKMCSQPDVSQLLSNIRLQCICHAALVLQGALTQPRSLQQPSLVVPYMLC 523

  Fly   140 ---SFGAQWMEMFEQDEDEHDTSTQEFLIRVTCKVMEEVEPIEALGALKAIFYPVLTELQKNIAK 201
               .||      |.|:           |:|.|.: .|||        .|.||.|:|..|.:...:
Frog   524 RNLPFG------FIQE-----------LVRTTYQ-DEEV--------FKHIFVPILQGLSQAATE 562

  Fly   202 LNLITMK-KNTFWILGYFVRDK------RAAVLGELLIDYTTPNPRASGSEYMD-TLLGSLLCIS 258
            .:|.:.. |.....||.....|      ...::..|.:....|...|||.|... :.|||...:|
Frog   563 CSLDSDNFKYPLMALGELCEIKFGKTHPVCCLITSLPLWLPKPLSPASGRELQRLSFLGSYFSLS 627

  Fly   259 ILPKTQ---TGKYEFFQELSINQT---DEALWALLSHHQQSIFLLVKQLLVLSPETKKKTLQWVG 317
            :..:..   ..||.....:::..|   .::|...|...:|.:|.::..:| |:.||::..|.::.
Frog   628 VFAEDDNKVVEKYFSGPAITLENTRVVSQSLQHYLESARQELFKIIHSIL-LNGETREAALNYMA 691

  Fly   318 NCLDANVPRGHLWSSINASLEQTAHSTSSDAFMTNLTAVLVRLCAPLCMPSLKVLLVDPTY---- 378
            ..::||:.:        |.::......|:|.||.|...||.:|.:     .:|:..|||.|
Frog   692 ALVNANIKK--------AQIQTDDRLVSTDGFMLNFLWVLQQLSS-----KIKLETVDPMYIFHP 743

  Fly   379 -CAV--PNKDRQAKGVSMLRAHAE--TCLLTSEEGEERLTAEKYNFVTEIFYMTHKCFELSNIPC 438
             |.:  |:.:      :.::|..|  |..::....:..|.:|. .|.||.|::|.....|:.:|.
Frog   744 KCRILLPSDE------TRIKASTEEVTSWMSDISNDPSLFSEP-KFPTECFFLTLHAHHLAILPS 801

  Fly   439 IERFVRVLRELQNTQMAYGEIVNSD------PNSEVAKNLFRMIRDQIQQVLTIKNTLAEPTNDM 497
            ..|::|.||.::.......|:.|::      |.:...:.:.:..:.|:::::..|
Frog   802 CRRYIRRLRAIRELNRTVEELKNNESQWKDSPLAARHREMLKRCKTQLKKLVRCK---------- 856

  Fly   498 YLLKFFEASAIWLTEIAMLPREIYEQCLDKRDFSPQVFR-------------NMELLSDTPPFVA 549
                   |.|    :..:|......:||   :|...|.:             .|.|..|.|...|
Frog   857 -------ACA----DTGLLDESFLRRCL---NFYGMVIQFLLRIMDPSYPNITMPLNLDIPKMFA 907

  Fly   550 PYMQSVPESIIDNISAFLNAARKLNGEQYINIYFSAHDAF-------FKMIILFMGSSALVKNPH 607
                ::||..:::::.||          :..:.::....|       ...:::.:.:...::||:
Frog   908 ----TLPEFYVEDVAEFL----------FFIVQYAPQVLFEPCTQDVATFLVVLLCNQNYIRNPY 958

  Fly   608 LRAKLAEALEFLLPSRIMGSHRKTFVSHVFDNHPDRLK-VVRSLLNVFVSIEMTGQSVQFEQKFN 671
            |.|||.|.:....|:.   .||......:.::||...| :|.||:..:..:|.||.:.:|..||.
Frog   959 LVAKLVEVMFVTNPAI---QHRTQKFFEMIESHPLSTKLLVPSLMKFYTDVEHTGSTSEFYDKFT 1020

  Fly   672 YRRPMYAIMEFLWTKPEHVQCFRDLAVEAEQNMDAIEPPIFLRFINLLINDAIFLLDESLSNLEQ 736
            .|..:..|.:.||....|...|.:.....:|         |:|:||:||||..|||||||.:|::
Frog  1021 IRYHISTIFKSLWQNMAHHSTFMEEFNSGKQ---------FVRYINMLINDTTFLLDESLESLKR 1076

  Fly   737 IKQLQQAQDNGE-WESLPHTEREQHMTNLQHLGMLARFDNIIGRDTINLLKLLTSKIKSIFCHNS 800
            |.::|:...|.| ||.||..:::...:.|.....::|....:..:|:::..:||.:::..|....
Frog  1077 IHEMQEEMRNKEHWEQLPRDQQQARQSQLAQDERVSRSYLALATETVDMFHILTKQVQKPFLRPE 1141

  Fly   801 MVDRMAAMLNYFLLNLVGPKKERFKVKDKKEFEFDPAQTVIEISHIYINLSSDESFCLAVSQDGR 865
            :..|:|||||:.|..|.|||....||::.:::.|:|.:.:.:::.||::|.. ..|..|::.|.|
Frog  1142 LGPRLAAMLNFNLQQLCGPKCRDLKVENPEKYGFEPKKLLDQLTDIYLHLDC-ARFAKAIADDQR 1205

  Fly   866 SYSEQLFSYAENILIRIGGGQLIGDMSEFAVKVARMGAQYKEE-------QEL-LADAPEEYLDP 922
            |||::||   |.::.::   :..|..|..|::..::.|:..||       .|: .:|||:|:.||
Frog  1206 SYSKELF---EEVISKM---KKAGIKSTIAIEKFKLLAEKVEEIVARNARAEIDYSDAPDEFRDP 1264

  Fly   923 IISTLMTDPVVLPSSKVTVDRSTIARHLLSDQTDPFNREPLTMDKVKSNEALKQEIESWIQGKRE 987
            ::.||||:||.|||..: :|||.|.||||:..||||||:.||.:.::....||::|::|::.|:.
Frog  1265 LMDTLMTEPVRLPSGTI-MDRSIILRHLLNSSTDPFNRQTLTENMLEPVPELKEKIQAWMRDKQN 1328

  Fly   988 A 988
            |
Frog  1329 A 1329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11070	NP_609060.1	Ufd2P_core	251..898	CDD:287392	162/689 (24%)
CG11070	NP_609060.1	U-box	915..987	CDD:252675	35/71 (49%)
ube4b	XP_031762209.1	Ufd2P_core	620..1240	CDD:402160	163/697 (23%)
ube4b	XP_031762209.1	RING-Ubox_UBE4B	1253..1327	CDD:319572	35/74 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D194967at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010