DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31633 and FBXL4

DIOPT Version :9

Sequence 1:NP_723199.1 Gene:CG31633 / 33931 FlyBaseID:FBgn0051633 Length:408 Species:Drosophila melanogaster
Sequence 2:NP_001265645.1 Gene:FBXL4 / 26235 HGNCID:13601 Length:621 Species:Homo sapiens


Alignment Length:346 Identity:77/346 - (22%)
Similarity:141/346 - (40%) Gaps:78/346 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 ENLNDDCVLKIVDYLDLEDQLKLWKSSEPASR-LRSLISYIWQRNREYTIDYYTFNDDYELLNEF 68
            :.|..:.:..|:::|.|.|..:|.::.:..|: ....:.|| ..|.:   .|:...||..|  ||
Human   281 DKLPYELIQLILNHLTLPDLCRLAQTCKLLSQHCCDPLQYI-HLNLQ---PYWAKLDDTSL--EF 339

  Fly    69 LQCIRFTVTELTLQYLAMDHLERWKGHT-FPNM----RQLIYLGDETSEIE-------GDADIAI 121
            ||. |.|:    :|:|.:.    |.|:. |.::    |.|...|.|...:|       .:..:.:
Human   340 LQS-RCTL----VQWLNLS----WTGNRGFISVAGFSRFLKVCGSELVRLELSCSHFLNETCLEV 395

  Fly   122 LVDCFPQLEAIRLSGKTTGNHISRWRNIRRLDLQLCWYLSPQGFEDICQNLRLQTLSIQWQKIEQ 186
            :.:..|.|:|:.||.                    |..|.||.|..|.:...|:.|.:...|:||
Human   396 ISEMCPNLQALNLSS--------------------CDKLPPQAFNHIAKLCSLKRLVLYRTKVEQ 440

  Fly   187 NAYVRSICMLHELEELELD--IVYLNRDNISQLLSLPKLIKLRLHNFYQVDDL----LCEIGSIR 245
            .|.:..:....||:.|.|.  ::..:.|.|:.::. .|..|||..:.::..::    :.|:.|  
Human   441 TALLSILNFCSELQHLSLGSCVMIEDYDVIASMIG-AKCKKLRTLDLWRCKNITENGIAELAS-- 502

  Fly   246 GQDVLTAAFSNNIWMRPTEVLAKLRNLRCLTLVDDEGCAAIDFSTITYCFPLLEQLHLENSRIWV 310
                            ...:|.:|....|.||....||    |:.:.:..|.|::|.|..:|...
Human   503 ----------------GCPLLEELDLGWCPTLQSSTGC----FTRLAHQLPNLQKLFLTANRSVC 547

  Fly   311 NADGIWDVLLACPRLREFSMI 331
            :.| |.::...|.||::..::
Human   548 DTD-IDELACNCTRLQQLDIL 567

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31633NP_723199.1 None
FBXL4NP_001265645.1 F-box-like 280..318 CDD:315592 7/36 (19%)
leucine-rich repeat 295..317 CDD:275381 5/21 (24%)
leucine-rich repeat 318..346 CDD:275381 12/34 (35%)
leucine-rich repeat 347..376 CDD:275381 8/32 (25%)
LRR 1 376..397 2/20 (10%)
leucine-rich repeat 377..398 CDD:275381 1/20 (5%)
AMN1 394..601 CDD:332986 47/218 (22%)
LRR 2 402..421 9/38 (24%)
leucine-rich repeat 403..427 CDD:275381 10/43 (23%)
LRR 3 427..448 6/20 (30%)
leucine-rich repeat 428..452 CDD:275381 6/23 (26%)
LRR 4 452..474 6/21 (29%)
leucine-rich repeat 453..480 CDD:275381 6/27 (22%)
LRR 5 480..501 4/20 (20%)
leucine-rich repeat 481..506 CDD:275381 4/42 (10%)
LRR 6 504..524 5/19 (26%)
leucine-rich repeat 507..534 CDD:275381 8/30 (27%)
LRR 7 532..558 7/26 (27%)
leucine-rich repeat 535..560 CDD:275381 7/25 (28%)
LRR 8 559..583 2/9 (22%)
leucine-rich repeat 561..586 CDD:275381 1/7 (14%)
LRR 9 584..609
leucine-rich repeat 587..612 CDD:275381
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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