DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango1 and SPZ1

DIOPT Version :9

Sequence 1:	NP_609058.2	Gene:	Tango1 / 33930	FlyBaseID:	FBgn0286898	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_115956.3	Gene:	SPZ1 / 84654	HGNCID:	30721	Length:	430	Species:	Homo sapiens

Alignment Length:	440	Identity:	93/440 - (21%)
Similarity:	165/440 - (37%)	Gaps:	123/440 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   821 SQEGAL--LSKLNHLERSLLASHKENLIIKHDLMTTRTKLASIEDNSFGSNDMVADLKKQLESEL 883
            |..|:|  |...:|.......:.|.|.::|        ::..|..|..|..:.:.:.|     ||
Human    45 SSWGSLPFLKNSSHQVTEQQTAQKFNNLLK--------EIKDILKNMAGFEEKITEAK-----EL 96

  Fly   884 YEKAKLQEQVGSLERDLDNAAEAGLE-LNKMLSEVLNGQNGDEAFMSTVDELQRQLNDQEKIIIE 947
            :|:..:.|.|.:.:.::     .||: :|:|||..|.        :|...|.:.....|| :|:|
Human    97 FEETNITEDVSAHKENI-----RGLDKINEMLSTNLP--------VSLAPEKEDNEKKQE-MILE 147

  Fly   948 INNSLAEKSRENSE----LQYTFTEATTRLNSELKTLQEDNYE-----LEMEKSK---------L 994
            .|  :.|....:.|    |.......:|.|...|...:|||.:     :|.:.|:         |
Human   148 TN--ITEDVSAHKENIRGLDKINEMLSTNLPVSLAPEKEDNEKKQQMIMENQNSENTAQVFARDL 210

  Fly   995 QTRLQE--IQAETESELAKALEARNY--EMQKLQN---QIVELTVKWEREHGDLQTSLAKI---- 1048
            ..||:|  :..||:....||....|.  |..|::|   |:::....|.::|    |.|:|:
Human   211 VNRLEEKKVLNETQQSQEKAKNRLNVQEETMKIRNNMEQLLQEAEHWSKQH----TELSKLIKSY 271

  Fly  1049 -EALEDCLKAVGKDAIHNVQELITSAKTRGELNAVHKKLVELQSKVEQEEAHKQRLESQLQQSSQ 1112
             ::.:|..:.:|.:.                        |..|::...|.:.|..||.|:::.|.
Human   272 QKSQKDISETLGNNG------------------------VGFQTQPNNEVSAKHELEEQVKKLSH 312

  Fly  1113 DVEQLKQDFNQSERDKLEAQTRLEVLSGYFREKENDLKKELSLQETKWLQHQGENASTVETQTLM 1177
            |...|:......|.:....|.|:|:|                    |.|.||.:  .|::.:.:.
Human   313 DTYSLQLMAALLENECQILQQRVEIL--------------------KELHHQKQ--GTLQEKPIQ 355

  Fly  1178 KNEIQTLKSQNDELRAEIEAQIASHKAQMGTLENRAHESWLAARQSERRC 1227
            .|..|..|:|......::|....:.:|..||.       |    :.:|.|
Human   356 INYKQDKKNQKPSEAKKVEMYKQNKQAMKGTF-------W----KKDRSC 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango1	NP_609058.2	SH3	42..113	CDD:302595
		GBP_C	<495..585	CDD:303769
		PKK	496..606	CDD:289257
		coiled coil	560..571	CDD:293879
		Drf_FH1	<1291..1337	CDD:283903
SPZ1	NP_115956.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..25
		SMC_prok_B	<63..>340	CDD:274008	72/353 (20%)
		Helix-loop-helix motif. /evidence=ECO:0000255	166..177		2/10 (20%)
		Basic motif. /evidence=ECO:0000255	178..244		17/65 (26%)
		Leucine-zipper	303..324		6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158732
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930