Protein Alignment Tango1 and Mia3

DIOPT Version :10

• Sequence 1: NP_609058.2
• Gene: Tango1 / 33930
• FlyBaseID: FBgn0286898
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: NP_001385613.1
• Gene: Mia3 / 683007
• RGDID: 1591600
• Length: 1920
• Species: Rattus norvegicus
• Alignment Length: 2038
• Identity: 405/2038 - (19%)
• Similarity: 649/2038 - (31%)
• Gaps: 794/2038 - (38%)

  Fly    29 PTLTWAATLSDKRLCADPKCEQIISMGIAKITYAIGGEGLISFKINSPIRVLSKSAGSNMQLWGV 93
            |.|:.....||.::|.|.:|..::..|.|...:.......::||....:.|..|.||.:.::|..
  Rat    24 PDLSPGRRFSDLKVCGDAECSMLMYRGKALEDFTGPDCRFVNFKKGDDVYVYYKLAGGSPEVWAG 88

  Fly    94 DINGRRGYANKDFI--------------------------------------------------- 107
            .:....||..||.|
  Rat    89 SVRQSFGYFPKDLIKVLHKYTEEELRVPADETDFVCFEGGRDDFNSYNIEELLGFLELEDSVPEK 153

  Fly   108 MEKKILV---RDK----------DLLYEVPVV------GPGSPVQSVETPVQSVETTVQPVLNAS 153
            :||...|   |:|          ||..|..||      |.|:..:|.|      |...||....|
  Rat   154 LEKAAEVSQHREKSPEGSREHELDLASEPEVVRVDSEDGEGAFSESTE------ELQGQPSAQES 212

  Fly   154 ESTDDLATTTTSPLEIAVDSIVVEHDKLQ----DQQVPDPTAASKAQ-----VQVIEGTELPLEA 209
            ....|.|......::.::|:.   .|||:    :.:..:.:.||..|     .||:. ||:.::
  Rat   213 HPHPDTAAANAQGVQSSLDTF---EDKLKVPGTENRTGNSSPASVEQEKTDAYQVLR-TEMSID- 272

  Fly   210 IAATTEGSIVPETAADPQEATNL--------------------------DS-------TVVDTKE 241
             ..|..||......:| .|||.|                          ||       |.||..|
  Rat   273 -LKTKFGSTADALVSD-DEATRLVTSLEDGFDEELDAEYYLMDDEEEHTDSSDELPLLTFVDNDE 335

  Fly   242 --------PQALNSEAIKLQEEPKAQ--------------------------------------- 259
                    .:.|..:...|.||.|.:
  Rat   336 KAPGEPTMEKYLTDKDPNLNEEDKVEPSLAPGIRNDNKDVLTTWGDTFFSIVTGGEGKSGVVDLE 400

  Fly   260 ---------QPATEAEKPPPLP-------QAINAELEDADDFDYGDDETD------------DDS 296
                     ..::...||.|.|       :..:..:|:....|..|.|||            .:|
  Rat   401 RSLQEEDLLASSSHQRKPRPTPGYPARDDEGGDLLVEEPKTSDVKDSETDPELVNTGEGKDVQES 465

  Fly   297 QQG-----SQD-----------------------------------------NESIVEIANDNKS 315
            :.|     |:|                                         .|.::.|:.:...
  Rat   466 RGGLAHPESEDAKSETASAYRPQNSKLNPLPAAAKGKDFTLKAVFEKKENGLKEPVIHISKETVH 530

  Fly   316 INESIELK------------------------PLSVAQLKKTDKVEDSKDETKEKHAEMEVSK-- 354
            .:::.|:|                        ||.||.|...:|.:.|||.|:.....:..||
  Rat   531 EDKTREMKGDGLESELVHRAARSSEVENNKHQPLGVAPLVGNNKPDASKDSTEVPDTSVSGSKAG 595

  Fly   355 --------------QEDSSLPTETLNVTALEEQIDQKEFP--------KQVLD-AAVELKSSDP- 395
                          |...|.|.|    |.|..::..| .|        :|..| |||..|.:|.
  Rat   596 QQEGFREPGLKTQNQPRFSPPEE----TGLSRELGGK-VPISGRNLSRQQERDVAAVVSKHADEK 655

  Fly   396 --LPVEEVTE--TVAEPPRTIVEDKINEEIVPVSAKIQAKPATVNPTEPIVAQSDAEIKA----- 451
              .|.||..|  |.||||:  |..:..|...|       :..:|.|.:|.|.:.:.|.:.
  Rat   656 TGFPEEEGREDLTDAEPPK--VTQRTQEAESP-------EVLSVQPVKPEVEEEEEEEEEEEEDH 711

  Fly   452 -PSESVISSTTPAPVVEEAPQKADPVGLPP-----LFEK-----------KNFENPNNYY----- 494
             |.|.::.........:.........|..|     :|||           || ::|.|..
  Rat   712 DPHEVLLEDENAVSAQQSRENHPSTHGRRPDMNSQVFEKVILGTLNLNTEKN-KHPANVILDTGK 775

  Fly   495 --KQLQEE-----QEKQRLVAEAEE-------------------QKRLQEEADQQKRLQE----- 528
              :...||     :|...:|.:.||                   :|..|....::..|:|
  Rat   776 KSETTSEEAGDMGKESGSVVVDREESHVADVRAQGPSQVHSLPDKKAAQTPGSKEAVLRENPSDL 840

  Fly   529 -----EAALNKRLLE----------EAEQQKRLQEEAEQ-----------------------QKR 555
                 |...|...||          |.|..|:|.:...|                       .|.
  Rat   841 QKDNPEGPRNTLGLEDPGGEEISGGELEDTKKLGDSESQGPDAEDLGDDPSQRATPEIPDIVLKS 905

  Fly   556 LQEE------------------------AELNKRLLEEAEKQKRLHEES---------EQLQRSS 587
            ::|:                        .||...|.:.:.|.:..|.:|         :::.|:|
  Rat   906 IREDMPIINSFFKDDQQSLYRFLKYFDVRELEGLLQDMSIKLRSAHRDSLPYNVEKVLDKVFRAS 970

  Fly   588 EE-----AEPQLSVQEANMQQLNDSVDS--QSNEIVDNNNRQQPEQYQQHHHHTESAFNHPSTAS 645
            |.     ||..|....:.::.|:...:|  :..|::|:        .|...:.....::...||.
  Rat   971 ESLILSVAEKMLDTPVSKIRDLDAKENSPLEEAEVLDD--------IQDLIYFVRYQYSGVETAP 1027

  Fly   646 HTTPTPDAESPYAAVQEETTEASQTDNHREGVGYV------------EPVA---LPATA----SP 691
            ..||.|..|. :|...||...|.|....:|..|.:            :||.   ||...    .|
  Rat  1028 LATPPPPEEG-WAGPGEEMQPAQQDRLPQENTGDISVQVSEDRNLLDQPVTSVQLPEEPDLLDQP 1091

  Fly   692 VSEVPIKEDAAGFGLFATIVDTVNNFIGKDPQSDPADSSDELHRILYPGRPEV--PPSQRKAED- 753
            |:.|.:.||          .|.:|     .|.::            ||...|:  .||..|..|
  Rat  1092 VTSVQLPED----------TDVLN-----QPMTE------------YPSASEISQKPSTEKEIDL 1129

  Fly   754 -FAPA-------DVDGYCARFQAKDEHC----HRSISLDNFVEVMADKLV----DHSQ------- 795
             |.|.       |::....|...:....    ..|.||.:|:..::..||    |..|
  Rat  1130 GFVPEGGPVGADDIEKQQERTAERPADAPPLESTSGSLYSFILYLSKMLVATLPDSVQPGPDFYG 1194

  Fly   796 -----LLLCVVIAAISSLFFMFAYYCFC-------------------NSSQEGA-LLSKLNHLER 835
                 :::..|:..:|  |.:|::....                   |..:|.| |:.||:..|:
  Rat  1195 LPWQPVVVTAVLGVVS--FAIFSWRTILVVKSRIYQVTEKQISEKLENIKKENAELMQKLSSYEQ 1257

  Fly   836 SLLAS-------HKENLIIKHDLMTTRTKLASIEDNSFGSNDMVADLKKQLESELYEKAKLQEQV 893
            .:..|       .|:|||:..:.:..:.|:..:|:.:....|....|:.|||||..:..|.|:.:
  Rat  1258 KIKESKKYVQETKKQNLILSDEAIKYKDKIKVLEETNVSLGDKAKSLRLQLESEREQNVKNQDLI 1322

  Fly   894 GSLERDLDNAAEAGLELNKMLSEVLNGQNGDEAFMSTVDELQRQLNDQEKIIIEINNSLAEKSRE 958
            ...::.::.           |.:|:: .|..|     :.|:|..||:            |:.|.|
  Rat  1323 LENKKSIEK-----------LKDVIS-MNASE-----LSEVQVALNE------------AKLSEE 1358

  Fly   959 NSELQYTFTEATTRLNSELKTLQEDNYELEMEKSKLQTRLQE---IQAE----------TESELA 1010
            |             :.||...:||:|..|:.:|.:||.:::|   ..||          ::.:|.
  Rat  1359 N-------------VKSECHRVQEENARLKKKKEQLQQQIEEWSRSHAELTEQIRSFETSQKDLE 1410

  Fly  1011 KALEARNYEMQKLQNQIVELT-VKWEREH------GDLQTSLAKIEALEDCLKAVGKDAIHNVQE 1068
            .||..::..:..|.|.|.:|. ::.|.|.      |:....||..|...|..|.: ||   .:::
  Rat  1411 VALTHKDDNISALTNCITQLNRLECELESEDADKGGNESDELANGEMGGDRSKKI-KD---RIKQ 1471

  Fly  1069 LITSAKTRGELNAVHKKLVELQSKVEQEEAHKQRLESQLQQSSQDVEQLKQDFNQSERDKLEAQT 1133
            ::..::|:..::.|.:.|..||.|:....:.|..||.|:::...|...|:......|.:....:.
  Rat  1472 MMDVSRTQTAVSIVEEDLKLLQLKLRASMSTKCNLEDQIKKLEDDRSSLQTAKAGLEDECKTLRQ 1536

  Fly  1134 RLEVLSGYFREKENDLKKELSLQETKWLQHQGENASTVETQTLMKNEIQTLKSQNDELRAEIEAQ 1198
            ::|:|:..:::||..|:|:||.:|.:....:.:..:..|...|...|::|.|.:.:|:..|::..
  Rat  1537 KVEILNELYQQKEMALQKKLSQEEYERQDREQKLTAADEKVVLAAEEVKTYKRRIEEMEEELQKT 1601

  Fly  1199 IASHKAQMGTLENRAHESWLAARQSERRCEEALAEAASLRRKLTTM------------------- 1244
            ..|.|.|:...|.:||::||.||.:||...|...|||:||.||..|
  Rat  1602 ERSFKNQIAAHEKKAHDNWLKARAAERAMAEEKREAANLRHKLLEMTQKMAMRQDEPVIVKPMPG 1666

  Fly  1245 -----------------------ASGG-----------------------------GGV------ 1251
                                   .|||                             |.:
  Rat  1667 RPNTQNPPRRGLLSQNGSFGPSPVSGGECSPPLPVESPGRPLSATLSRRDTPRSEFGSLDRHLPR 1731

  Fly  1252 ------------GGDPGVMEAIAANGTSVLGA------ELKTAP-SPLPLPGSPLLNMP------ 1291
                        ..|||....:.::..|...|      ::..|| .|.|.||.||:..|
  Rat  1732 PRWPSEASGKHSASDPGPPPVVNSSSRSSSPAKAMDEGKVNMAPKGPPPFPGVPLMGGPVPPPIR 1796

  Fly  1292 -NPLPFLAAPFSPFMGLPPPFLPPTGAGGARPPPLGRMRSPPPSSRGDRD-----RERYSDYSDY 1350
             .|.|.|..||.| ..|||||:|     |.| ||||.....|....|.||     ||....::.:
  Rat  1797 YGPPPQLCGPFGP-RPLPPPFVP-----GMR-PPLGVREYAPGVLPGKRDLPVDPREFVPGHTPF 1854

  Fly  1351 DDYDDDEEDDRGMDRRRRHSGSWGRRH---RGSY----SHSPRTYRSLSPSDSRYNYNDTETDFS 1408
                             |..||.|.|.   .|:.    ||.|:.|
  Rat  1855 -----------------RPPGSLGPREFFIPGTRLPPPSHGPQDY-------------------- 1882

  Fly  1409 PPPSP---PPVPSGRSATSRPYS 1428
            |||.|   ..:|||....::|.|
  Rat  1883 PPPPPALRDSLPSGPREEAQPAS 1905

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tango1	NP_609058.2	SH3	42..113	CDD:473055	19/121 (16%)
		PTZ00121	<191..672	CDD:173412	148/829 (18%)
		Smc	<495..>623	CDD:440809	37/234 (16%)
		SMC_prok_B	854..>1197	CDD:274008	81/362 (22%)
		CwlO1	1078..>1335	CDD:443091	86/359 (24%)
Mia3	NP_001385613.1	SH3	38..109	CDD:473055	17/70 (24%)
		Mplasa_alph_rch	<1230..1615	CDD:275316	97/430 (23%)
		PHA03307	1665..>1920	CDD:223039	61/285 (21%)