DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tango1 and Mia3

DIOPT Version :9

Sequence 1:	NP_609058.2	Gene:	Tango1 / 33930	FlyBaseID:	FBgn0286898	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	XP_038947420.1	Gene:	Mia3 / 683007	RGDID:	1591600	Length:	1920	Species:	Rattus norvegicus

Alignment Length:	2038	Identity:	405/2038 - (19%)
Similarity:	649/2038 - (31%)	Gaps:	794/2038 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PTLTWAATLSDKRLCADPKCEQIISMGIAKITYAIGGEGLISFKINSPIRVLSKSAGSNMQLWGV 93
            |.|:.....||.::|.|.:|..::..|.|...:.......::||....:.|..|.||.:.::|..
  Rat    24 PDLSPGRRFSDLKVCGDAECSMLMYRGKALEDFTGPDCRFVNFKKGDDVYVYYKLAGGSPEVWAG 88

  Fly    94 DINGRRGYANKDFI--------------------------------------------------- 107
            .:....||..||.|
  Rat    89 SVRQSFGYFPKDLIKVLHKYTEEELRVPADETDFVCFEGGRDDFNSYNIEELLGFLELEDSVPEK 153

  Fly   108 MEKKILV---RDK----------DLLYEVPVV------GPGSPVQSVETPVQSVETTVQPVLNAS 153
            :||...|   |:|          ||..|..||      |.|:..:|.|      |...||....|
  Rat   154 LEKAAEVSQHREKSPEGSREHELDLASEPEVVRVDSEDGEGAFSESTE------ELQGQPSAQES 212

  Fly   154 ESTDDLATTTTSPLEIAVDSIVVEHDKLQ----DQQVPDPTAASKAQ-----VQVIEGTELPLEA 209
            ....|.|......::.::|:.   .|||:    :.:..:.:.||..|     .||:. ||:.::
  Rat   213 HPHPDTAAANAQGVQSSLDTF---EDKLKVPGTENRTGNSSPASVEQEKTDAYQVLR-TEMSID- 272

  Fly   210 IAATTEGSIVPETAADPQEATNL--------------------------DS-------TVVDTKE 241
             ..|..||......:| .|||.|                          ||       |.||..|
  Rat   273 -LKTKFGSTADALVSD-DEATRLVTSLEDGFDEELDAEYYLMDDEEEHTDSSDELPLLTFVDNDE 335

  Fly   242 --------PQALNSEAIKLQEEPKAQ--------------------------------------- 259
                    .:.|..:...|.||.|.:
  Rat   336 KAPGEPTMEKYLTDKDPNLNEEDKVEPSLAPGIRNDNKDVLTTWGDTFFSIVTGGEGKSGVVDLE 400

  Fly   260 ---------QPATEAEKPPPLP-------QAINAELEDADDFDYGDDETD------------DDS 296
                     ..::...||.|.|       :..:..:|:....|..|.|||            .:|
  Rat   401 RSLQEEDLLASSSHQRKPRPTPGYPARDDEGGDLLVEEPKTSDVKDSETDPELVNTGEGKDVQES 465

  Fly   297 QQG-----SQD-----------------------------------------NESIVEIANDNKS 315
            :.|     |:|                                         .|.::.|:.:...
  Rat   466 RGGLAHPESEDAKSETASAYRPQNSKLNPLPAAAKGKDFTLKAVFEKKENGLKEPVIHISKETVH 530

  Fly   316 INESIELK------------------------PLSVAQLKKTDKVEDSKDETKEKHAEMEVSK-- 354
            .:::.|:|                        ||.||.|...:|.:.|||.|:.....:..||
  Rat   531 EDKTREMKGDGLESELVHRAARSSEVENNKHQPLGVAPLVGNNKPDASKDSTEVPDTSVSGSKAG 595

  Fly   355 --------------QEDSSLPTETLNVTALEEQIDQKEFP--------KQVLD-AAVELKSSDP- 395
                          |...|.|.|    |.|..::..| .|        :|..| |||..|.:|.
  Rat   596 QQEGFREPGLKTQNQPRFSPPEE----TGLSRELGGK-VPISGRNLSRQQERDVAAVVSKHADEK 655

  Fly   396 --LPVEEVTE--TVAEPPRTIVEDKINEEIVPVSAKIQAKPATVNPTEPIVAQSDAEIKA----- 451
              .|.||..|  |.||||:  |..:..|...|       :..:|.|.:|.|.:.:.|.:.
  Rat   656 TGFPEEEGREDLTDAEPPK--VTQRTQEAESP-------EVLSVQPVKPEVEEEEEEEEEEEEDH 711

  Fly   452 -PSESVISSTTPAPVVEEAPQKADPVGLPP-----LFEK-----------KNFENPNNYY----- 494
             |.|.::.........:.........|..|     :|||           || ::|.|..
  Rat   712 DPHEVLLEDENAVSAQQSRENHPSTHGRRPDMNSQVFEKVILGTLNLNTEKN-KHPANVILDTGK 775

  Fly   495 --KQLQEE-----QEKQRLVAEAEE-------------------QKRLQEEADQQKRLQE----- 528
              :...||     :|...:|.:.||                   :|..|....::..|:|
  Rat   776 KSETTSEEAGDMGKESGSVVVDREESHVADVRAQGPSQVHSLPDKKAAQTPGSKEAVLRENPSDL 840

  Fly   529 -----EAALNKRLLE----------EAEQQKRLQEEAEQ-----------------------QKR 555
                 |...|...||          |.|..|:|.:...|                       .|.
  Rat   841 QKDNPEGPRNTLGLEDPGGEEISGGELEDTKKLGDSESQGPDAEDLGDDPSQRATPEIPDIVLKS 905

  Fly   556 LQEE------------------------AELNKRLLEEAEKQKRLHEES---------EQLQRSS 587
            ::|:                        .||...|.:.:.|.:..|.:|         :::.|:|
  Rat   906 IREDMPIINSFFKDDQQSLYRFLKYFDVRELEGLLQDMSIKLRSAHRDSLPYNVEKVLDKVFRAS 970

  Fly   588 EE-----AEPQLSVQEANMQQLNDSVDS--QSNEIVDNNNRQQPEQYQQHHHHTESAFNHPSTAS 645
            |.     ||..|....:.::.|:...:|  :..|::|:        .|...:.....::...||.
  Rat   971 ESLILSVAEKMLDTPVSKIRDLDAKENSPLEEAEVLDD--------IQDLIYFVRYQYSGVETAP 1027

  Fly   646 HTTPTPDAESPYAAVQEETTEASQTDNHREGVGYV------------EPVA---LPATA----SP 691
            ..||.|..|. :|...||...|.|....:|..|.:            :||.   ||...    .|
  Rat  1028 LATPPPPEEG-WAGPGEEMQPAQQDRLPQENTGDISVQVSEDRNLLDQPVTSVQLPEEPDLLDQP 1091

  Fly   692 VSEVPIKEDAAGFGLFATIVDTVNNFIGKDPQSDPADSSDELHRILYPGRPEV--PPSQRKAED- 753
            |:.|.:.||          .|.:|     .|.::            ||...|:  .||..|..|
  Rat  1092 VTSVQLPED----------TDVLN-----QPMTE------------YPSASEISQKPSTEKEIDL 1129

  Fly   754 -FAPA-------DVDGYCARFQAKDEHC----HRSISLDNFVEVMADKLV----DHSQ------- 795
             |.|.       |::....|...:....    ..|.||.:|:..::..||    |..|
  Rat  1130 GFVPEGGPVGADDIEKQQERTAERPADAPPLESTSGSLYSFILYLSKMLVATLPDSVQPGPDFYG 1194

  Fly   796 -----LLLCVVIAAISSLFFMFAYYCFC-------------------NSSQEGA-LLSKLNHLER 835
                 :::..|:..:|  |.:|::....                   |..:|.| |:.||:..|:
  Rat  1195 LPWQPVVVTAVLGVVS--FAIFSWRTILVVKSRIYQVTEKQISEKLENIKKENAELMQKLSSYEQ 1257

  Fly   836 SLLAS-------HKENLIIKHDLMTTRTKLASIEDNSFGSNDMVADLKKQLESELYEKAKLQEQV 893
            .:..|       .|:|||:..:.:..:.|:..:|:.:....|....|:.|||||..:..|.|:.:
  Rat  1258 KIKESKKYVQETKKQNLILSDEAIKYKDKIKVLEETNVSLGDKAKSLRLQLESEREQNVKNQDLI 1322

  Fly   894 GSLERDLDNAAEAGLELNKMLSEVLNGQNGDEAFMSTVDELQRQLNDQEKIIIEINNSLAEKSRE 958
            ...::.::.           |.:|:: .|..|     :.|:|..||:            |:.|.|
  Rat  1323 LENKKSIEK-----------LKDVIS-MNASE-----LSEVQVALNE------------AKLSEE 1358

  Fly   959 NSELQYTFTEATTRLNSELKTLQEDNYELEMEKSKLQTRLQE---IQAE----------TESELA 1010
            |             :.||...:||:|..|:.:|.:||.:::|   ..||          ::.:|.
  Rat  1359 N-------------VKSECHRVQEENARLKKKKEQLQQQIEEWSRSHAELTEQIRSFETSQKDLE 1410

  Fly  1011 KALEARNYEMQKLQNQIVELT-VKWEREH------GDLQTSLAKIEALEDCLKAVGKDAIHNVQE 1068
            .||..::..:..|.|.|.:|. ::.|.|.      |:....||..|...|..|.: ||   .:::
  Rat  1411 VALTHKDDNISALTNCITQLNRLECELESEDADKGGNESDELANGEMGGDRSKKI-KD---RIKQ 1471

  Fly  1069 LITSAKTRGELNAVHKKLVELQSKVEQEEAHKQRLESQLQQSSQDVEQLKQDFNQSERDKLEAQT 1133
            ::..::|:..::.|.:.|..||.|:....:.|..||.|:::...|...|:......|.:....:.
  Rat  1472 MMDVSRTQTAVSIVEEDLKLLQLKLRASMSTKCNLEDQIKKLEDDRSSLQTAKAGLEDECKTLRQ 1536

  Fly  1134 RLEVLSGYFREKENDLKKELSLQETKWLQHQGENASTVETQTLMKNEIQTLKSQNDELRAEIEAQ 1198
            ::|:|:..:::||..|:|:||.:|.:....:.:..:..|...|...|::|.|.:.:|:..|::..
  Rat  1537 KVEILNELYQQKEMALQKKLSQEEYERQDREQKLTAADEKVVLAAEEVKTYKRRIEEMEEELQKT 1601

  Fly  1199 IASHKAQMGTLENRAHESWLAARQSERRCEEALAEAASLRRKLTTM------------------- 1244
            ..|.|.|:...|.:||::||.||.:||...|...|||:||.||..|
  Rat  1602 ERSFKNQIAAHEKKAHDNWLKARAAERAMAEEKREAANLRHKLLEMTQKMAMRQDEPVIVKPMPG 1666

  Fly  1245 -----------------------ASGG-----------------------------GGV------ 1251
                                   .|||                             |.:
  Rat  1667 RPNTQNPPRRGLLSQNGSFGPSPVSGGECSPPLPVESPGRPLSATLSRRDTPRSEFGSLDRHLPR 1731

  Fly  1252 ------------GGDPGVMEAIAANGTSVLGA------ELKTAP-SPLPLPGSPLLNMP------ 1291
                        ..|||....:.::..|...|      ::..|| .|.|.||.||:..|
  Rat  1732 PRWPSEASGKHSASDPGPPPVVNSSSRSSSPAKAMDEGKVNMAPKGPPPFPGVPLMGGPVPPPIR 1796

  Fly  1292 -NPLPFLAAPFSPFMGLPPPFLPPTGAGGARPPPLGRMRSPPPSSRGDRD-----RERYSDYSDY 1350
             .|.|.|..||.| ..|||||:|     |.| ||||.....|....|.||     ||....::.:
  Rat  1797 YGPPPQLCGPFGP-RPLPPPFVP-----GMR-PPLGVREYAPGVLPGKRDLPVDPREFVPGHTPF 1854

  Fly  1351 DDYDDDEEDDRGMDRRRRHSGSWGRRH---RGSY----SHSPRTYRSLSPSDSRYNYNDTETDFS 1408
                             |..||.|.|.   .|:.    ||.|:.|
  Rat  1855 -----------------RPPGSLGPREFFIPGTRLPPPSHGPQDY-------------------- 1882

  Fly  1409 PPPSP---PPVPSGRSATSRPYS 1428
            |||.|   ..:|||....::|.|
  Rat  1883 PPPPPALRDSLPSGPREEAQPAS 1905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango1	NP_609058.2	SH3	42..113	CDD:302595	19/121 (16%)
		GBP_C	<495..585	CDD:303769	27/189 (14%)
		PKK	496..606	CDD:289257	34/214 (16%)
		coiled coil	560..571	CDD:293879	3/10 (30%)
		Drf_FH1	<1291..1337	CDD:283903	20/52 (38%)
Mia3	XP_038947420.1	SH3	38..109	CDD:418401	17/70 (24%)
		Mplasa_alph_rch	<1230..1615	CDD:275316	97/430 (23%)
		PHA03307	1665..>1920	CDD:223039	61/285 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46296
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23158
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010