DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango1 and CTAGE9

DIOPT Version :9

Sequence 1:	NP_609058.2	Gene:	Tango1 / 33930	FlyBaseID:	FBgn0286898	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_001139131.1	Gene:	CTAGE9 / 643854	HGNCID:	37275	Length:	777	Species:	Homo sapiens

Alignment Length:	745	Identity:	165/745 - (22%)
Similarity:	293/745 - (39%)	Gaps:	160/745 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   794 SQLLLC-VVIAAISSLFFMFAYY------CFCNSSQE-GALLS-----KLNHLER-SLLASHKEN 844
            |:|::| .||.....|.|::..:      .:....|: ||.||     |...||: ||:....|.
Human    41 SELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEG 105

  Fly   845 LIIKHDLMTTRTKLASIEDNSF--GSNDMVADLKKQLESELYEKAKLQEQVGSLERDLDNAAEAG 907
            ..::          :|:||.||  .:.:....|:...|......::|::::..||:||.......
Human   106 YEVE----------SSLEDASFEKAAAEEARSLEATCEKLSRSNSELEDEILCLEKDLKEEKSKH 160

  Fly   908 LELNKMLSEVLNGQNGDEAFMSTVDE---LQRQLND-----------QEKIIIEINNSLAEKSRE 958
            .:.:::::::      .::..|..||   |:.|:.:           :|:..|.|.::|.|.|:.
Human   161 SQQDELMADI------SKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNENSQL 219

  Fly   959 NSELQYTFTEATTRLNSELKTLQEDNYELEMEKSKLQTRLQEIQAETESELAKAL---------E 1014
            .:..:..|.:.......::..|.:.  ::..|.||:..  :::..:.|:.: |.|         :
Human   220 QTSHKQLFQQEAEVWKGQVSELNKQ--KITFEDSKVHA--EQVLNDKENHI-KTLTGHLPMMKDQ 279

  Fly  1015 ARNYEMQKLQNQIVELTVKWEREHGDLQTSLAKIEALEDCLKAVGKDAIHNVQELITSAKTRGEL 1079
            |...|.....:..:||.|..:.|:|         ..|:|..|...|..||..:..::.....||.
Human   280 AAVLEEDTTDDDNLELKVNSQWENG---------ANLDDPPKGALKKLIHAAKLNVSLKSLEGER 335

  Fly  1080 NAVHKKLVELQSKVEQEEAHKQRLESQLQQSSQDVEQLKQDFNQSERDKLEAQTRLEVLSGYFRE 1144
            |.:..:|.|:....|:...|.:.|  |.||:|...|.:   :.:||..||  |.:|::::.:::|
Human   336 NHIIIQLSEVDKTKEELTEHIKNL--QTQQASLQSENI---YFESENQKL--QQKLKIMTEFYQE 393

  Fly  1145 KENDLKKELSLQETKWLQHQGENASTVETQ-TLMKNEIQTLKSQNDELRAEIEAQIASHKAQMGT 1208
            .|..|.::|:::|...::.: |..|.||.: :....|::|.:....:|..|:|..:..::.|:.:
Human   394 NEMKLYRKLTVEENYRIEEE-EKLSRVEEKISHATEELETYRKLAKDLEEELERTVHFYQKQVIS 457

  Fly  1209 LENRAHESWLAARQSERRCEEALAEAASLRRKLTTMASGGGGVGGDPGVMEAIAANGTSVLGAE- 1272
            .|.|.|::|||||.:||...:...|.|..::|||........:..||..::.    ..:..|.|
Human   458 YEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTERELKFELLEKDPNALDV----SNTAFGREH 518

  Fly  1273 LKTAPSPLPLPGSPLLNMPNPLPFLAAPFSPFMGLPPPFLPPTGAGGARPPPLGR-MRSPPPSSR 1336
            ...:||||..|.|.....|:|...|..|..     ..|.||  |.||..|...|. :.....:.|
Human   519 SPCSPSPLGRPSSETRAFPSPQTLLEDPLR-----LSPVLP--GGGGRGPSSPGNPLDHQITNER 576

  Fly  1337 GDRDRERYSD----YSDYDDYDDDEEDDRGM----------DRR---RRHSGSWGRRHRGSYSHS 1384
            |:...:|..|    .||........|.||.|          |..   :|....:....|.|....
Human   577 GEPSYDRLIDPHRAPSDTGSLSSPVEQDRRMMFPPPGQSYPDSTLPPQREDRFYSNSERLSGPAE 641

  Fly  1385 PRTYRSLS--------PSDSRYNYNDTETD--------------------------FSP------ 1409
            ||:::..|        ||:...:.||.:.|                          .:|
Human   642 PRSFKMTSLDKMDRSMPSEMESSRNDAKDDLGNLNVPDSSLPAENEATGPGLIPPPLAPISGPLF 706

  Fly  1410 ------------PPSPPPVPSGRSATSRPY 1427
                        ||.|||.|......||.|
Human   707 PVDTRGPFMRRGPPFPPPPPGTMFGASRGY 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango1	NP_609058.2	SH3	42..113	CDD:302595
		GBP_C	<495..585	CDD:303769
		PKK	496..606	CDD:289257
		coiled coil	560..571	CDD:293879
		Drf_FH1	<1291..1337	CDD:283903	12/46 (26%)
CTAGE9	NP_001139131.1	IncA	<43..188	CDD:282066	33/160 (21%)
		TPR_MLP1_2	123..244	CDD:285204	20/126 (16%)
		Ax_dynein_light	<157..229	CDD:287215	12/77 (16%)
		SYCE1	338..>445	CDD:291886	29/114 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..688		42/184 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	721..742		7/16 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158734
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002364
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23158
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.900