DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tango1 and mia3

DIOPT Version :9

Sequence 1:NP_609058.2 Gene:Tango1 / 33930 FlyBaseID:FBgn0286898 Length:1430 Species:Drosophila melanogaster
Sequence 2:XP_005160949.1 Gene:mia3 / 567041 ZFINID:ZDB-GENE-041014-270 Length:1874 Species:Danio rerio


Alignment Length:1925 Identity:371/1925 - (19%)
Similarity:668/1925 - (34%) Gaps:613/1925 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 LLIC-CLPTLTWAATLSDKRL-----CADPKCEQIISMGIAKITYAIGGEGLISFKINSPIRVLS 81
            ||:| |     :..:.||:|.     |||.:|..::..|.|...:.......:|||....|.|..
Zfish    15 LLLCSC-----FGGSCSDRRFSELKRCADEECSMLLGRGKAAKDFTGPDCRFLSFKKGETIYVYY 74

  Fly    82 KSAGSNMQLWGVDINGRRGYANKDFI------MEKKILV-------------RDKDLLYEVPVVG 127
            |.:|....:|...:....||..||::      .||::.|             .||...|::.|:.
Zfish    75 KLSGQRSDVWAGSVGNHFGYFPKDYLNINHIYTEKELEVPTEETDFVCFETGLDKFESYDIDVLL 139

  Fly   128 PGSPVQSVETPV-QSVETTVQPVLNASESTDDLATTTTSPLEIAVDSIVVEHDK---LQDQQVPD 188
            .......:|... :|.|.....:....||.:.|.:      |..::|..|..:.   ||.:.:..
Zfish   140 GSKLFMEIENSTEESKEADPYDISETEESVEHLDS------ESLLESEAVHSESRLPLQSELIDS 198

  Fly   189 PTAASKAQVQVIEGTELPLE-----AIAATTEGSIVPET-------------AADPQ-------- 227
            .:.....|..|...::||||     ..:|:|..|:..||             |..|:        
Zfish   199 ESVLILQQESVDSESKLPLELESVNLESASTHKSVNSETESTHESEFVYSKPALTPESESVDSES 263

  Fly   228 -----------EATNLDSTVVDT---KEPQALNSEAIKLQEEPKAQQPATEAEKPPPLPQAINAE 278
                       :.||.:||...|   ...|:.:||:.|.....:::..:|::|.   :.::.::|
Zfish   264 RTKSIDSESTTQLTNSESTTQSTDSESRTQSTDSESTKQSTNSESRTQSTDSES---MLKSTDSE 325

  Fly   279 L-EDADDFDYGDDET--------------DDDSQQGSQDNESIVEIANDNKSINESIELKPLSVA 328
            | ..:.|.:..|.|:              |.:|...|.|:||..| :||::|...|.:..  |..
Zfish   326 LTTQSTDLESTDSESTAESTDSESTTQSNDLESTSQSTDSESTAE-SNDSESATRSNDSG--STL 387

  Fly   329 QLKKTDKVEDSKD--ETKEKHAEMEVSKQEDS---SLPTETLNVTALEEQIDQKEFPKQVLDA-A 387
            |...::....|.|  .|.:.:|....|:..||   :.|.::.:..|||.:..:.|.....|:: :
Zfish   388 QSNDSESATQSNDSGSTLQSNASESTSQSADSESTTQPIDSESTLALESESFESELKSLPLESES 452

  Fly   388 VELKSSDPLPVEEVTETVAEP-------PRTIVEDKINEE---IVPVSAKIQAKPATVNPTEPIV 442
            .:.:|:.||..|.|.....|.       |::..:|..:.:   :|...:.::.|.|....|:.:.
Zfish   453 FDSESTLPLKSESVDSESVEASESDTLIPKSTEDDSDSSQPKTVVSSESTLEPKEAATEETDTLT 517

  Fly   443 AQSDAEIK--------------------APSESVISSTTPAPVVE-EAPQKADPVGLPPLFEKKN 486
            :|.|.|.:                    :.|||.:.:.|....|: |.|  |....||....:|.
Zfish   518 SQDDVETQPSDFDALNIDDVELLHIQHDSDSESQLETQTAGLDVDIEEP--ASHKDLPLQTLEKT 580

  Fly   487 FENPNNYYKQLQEEQEKQR------------LVAEAEEQKRLQEE------------------AD 521
            .|:.:::...|.|:.|.:.            ||.:.:.|:..:||                  :|
Zfish   581 LEDEDSWSSALNEKSESKETESFHEHAKESLLVHDLKAQRDFEEEENIDDVEFSHSPHNTKSASD 645

  Fly   522 QQKRLQEEAALNKRLLEEAEQQKRLQEEAEQ-------------QKRLQEEAE---LNK------ 564
            :.:.:..|.||....|..:|..:..:|.|:.             .|.:.::|.   :|:      
Zfish   646 ESEVVPSEPALETLALNISEITENTKENADDFVMKASMNTNENAHKNIADDARDAAINRSQQPTE 710

  Fly   565 --------RLLEEAEKQKRLHEESEQLQRSSEEAEPQLSVQEANMQQLNDSVDSQSNEIVDNNNR 621
                    .:.|..|....|::..||:::...|.|..|.......:......:.::.|::::.|.
Zfish   711 SIDEDETENVSESPESAPLLYKTDEQIEKVKNELEDLLKNTLETEEDSPGGEEDEAEELLEDENA 775

  Fly   622 -----------QQPEQYQQHHHH--TESAFNHPSTASHTTPT-----PDAESPYA---------- 658
                       |.||..:||...  .||..:..:|.:..|.|     |..|..|:          
Zfish   776 LLSSNSPHLTDQNPEDNEQHDDDGLVESQQSENTTQADETETEEVGLPPEEPEYSDSVLRLTILR 840

  Fly   659 -AVQEETTEASQ-------------------------------TDNHREGVGYV----EPVALPA 687
             .:::|.||..|                               |:...:.:..:    |...|.|
Zfish   841 DHLKDEDTERMQKYFGLKNMFRIEAMFSDLDLEMKSAREMKTDTEEIEQTLDQITEASENSILDA 905

  Fly   688 TASPVSEVPIK--ED------------AAGFGLFATIV-----------DTV-------NNFIGK 720
            |...:::...|  ||            ||....|..||           |:|       :.:...
Zfish   906 TEDILNDRDRKALEDGLQKQPEMYDVEAAMLDAFQEIVFALRQKYSTASDSVPLVEEEQSAYERD 970

  Fly   721 DPQSD---------------PADSSDELHRILYPGRPEVPPSQRKAEDFA-PADVDGYCARFQAK 769
            ||::|               ||: :.|:|:......|.:.|......|.: ..|||     .:..
Zfish   971 DPRADAEEVNNLDITTEITEPAE-TPEMHKEQNESEPILNPELNVNPDLSHNKDVD-----LEED 1029

  Fly   770 DEHCHRS----ISLDNFVEV------MADKLVDHSQLLLCVVIAAISSLFFMFAYYCFCNSSQEG 824
            ..|.:|:    ||.::..|:      :.:|.||            |...|.|..    .:.|.|.
Zfish  1030 GGHFNRNKDAQISFEDAEEIQKGPHAILEKPVD------------IGFHFEMDP----SSGSLES 1078

  Fly   825 ALLSKLNHLE--------------RSLLASHKENLIIKHDLMTT--------------------- 854
            ..:|..:..|              :.|:...||||.:..:::.|                     
Zfish  1079 PSVSDFHDAETGSDSSDSSTSDELQDLVVLVKENLGVYGEILITALPEEWRPGPNFHGVPWEPVV 1143

  Fly   855 ---------------RTKLASIEDNSFGSNDMVADLKKQLESELYEKAKLQEQVGSLERDLDNAA 904
                           ||.|| |:..|:               :|.|| :|::::..|..:..:||
Zfish  1144 VTVAIGALTILMFFWRTVLA-IKGRSY---------------QLTEK-QLRDKIQQLLNEKSDAA 1191

  Fly   905 EAGLELNKMLSE-VLNGQNGDEAFMSTVDELQRQLNDQEKI----------IIEINNSLAEKSRE 958
            ....|||.|:.| ....||.:::..|:..|::...|..:|:          |.::|.::.:...|
Zfish  1192 NKITELNDMIKEREQRLQNSEKSLSSSQHEIKGLKNHHQKMQSQWEQMSGSISQLNQTIVDTQEE 1256

  Fly   959 NSELQYTFTEATTRLNSELKTLQEDNYELEMEKSKLQTRLQEIQAETESELAKAL--EARNYEMQ 1021
            |:.|....::...|:....|||:  ||  :.|::|:...:.|.:...::..|:.|  |..|..::
Zfish  1257 NANLNEKISKMHQRIEKYQKTLK--NY--DDERAKVHVLMDEAKLREDALKAQVLSFEKENGALK 1317

  Fly  1022 KLQNQIVELTVKWEREH--------------GDLQTSLA----KIEALEDCLKAVGK-------- 1060
            :.:..::.....|:.:|              .:|:.||.    :|:.|..|:..:.:        
Zfish  1318 EQKKSLLGDAKDWQEKHKKLSEEIRVYHKSQKELEDSLVHKENEIDVLSSCIAELNRLGGCDSAE 1382

  Fly  1061 ------------------DAIH-NVQELITSAKTRGELNAVHKKLVELQSKVEQEEAHKQRLESQ 1106
                              |.:. .:::::..::.:..|:.|..:.......:..|:..:|.||.|
Zfish  1383 LQKEDARMSNGDESEKKMDTMRLRIKQMMDVSRIKATLSVVEDERNRYMENLLAEQKSRQELEEQ 1447

  Fly  1107 LQQSSQDVEQLKQDFNQSERDKLEAQTRLEVLSGYFREKENDLKKELSLQETKWLQHQGENASTV 1171
            .|:...|...|..:....|......|.|||:.:..:::|||.|:::|:.:|.: .:.:....|.|
Zfish  1448 YQKVMHDQMNLNNEKTHLENQMKNLQQRLEITTELYQQKENALQQKLTQEELE-RREKETKLSEV 1511

  Fly  1172 ETQTL-MKNEIQTLKSQNDELRAEIEAQIASHKAQMGTLENRAHESWLAARQSERRCEEALAEAA 1235
            :::.| .:.|::.||.:..::..|::....|.|:::...|.:|||:||.||.|||...|...|:|
Zfish  1512 DSKALRSEEEVRALKQKIKDIEEEMQQNERSLKSEVAVQEKKAHENWLKARASERTLVEERRESA 1576

  Fly  1236 SLRRKLT--------------TMASG---------------------GGGVGGDPGVMEA----- 1260
            :||:||.              .:.||                     .||....|.::|.     
Zfish  1577 TLRQKLVEYRDKISDMEQSLFKLNSGPPDRHMPPPQRRGDSYGPSPVSGGAPSPPLMIEGPGRPP 1641

  Fly  1261 ---IAANGT--------------SVLGAELKTAP--------SPL----PLPGSPLLN------- 1289
               :...|.              |.||..|.:.|        ||.    |:..:|::.       
Zfish  1642 SAPVGRRGEPFGPRPPSDPHGRFSELGHPLPSRPEMFQPMTSSPCAHDGPMQTAPVVEPAESSDQ 1706

  Fly  1290 ------------------MPNPL-----PFLAAPFSPFMGLPPPFLPPTGAGGARPPPLGRMRSP 1331
                              :|:|:     |....|..|:   .||.:||.|......||.|.:...
Zfish  1707 ASSEPVESLSKSQSQGSFLPSPIRDSPVPPPNVPLKPY---GPPGMPPNGPPMMIRPPNGHLPMM 1768

  Fly  1332 PPSSRGDRDRERYSDYSDYDDYDDDEEDDRGMDRRRRHSGSWG-RRHRGSYSHSPRTYRSLSPSD 1395
            ||..|                            .|..|..|:| ..|.|.:...|..:....|..
Zfish  1769 PPDPR----------------------------FRPPHMDSYGPPPHIGPFGPVPPPFARGPPLG 1805

  Fly  1396 SRYNYNDTETDF------SPPPSPP-PVPSGRSATSRPYS 1428
            ......|...||      .|.|.|| |:|...:....|||
Zfish  1806 PPLGQRDVPPDFFAPRGLPPRPFPPGPLPPPGAMIPPPYS 1845

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tango1NP_609058.2 SH3 42..113 CDD:302595 20/81 (25%)
GBP_C <495..585 CDD:303769 24/149 (16%)
PKK 496..606 CDD:289257 27/169 (16%)
coiled coil 560..571 CDD:293879 3/27 (11%)
Drf_FH1 <1291..1337 CDD:283903 15/50 (30%)
mia3XP_005160949.1 SH3_MIA3 35..107 CDD:212826 18/71 (25%)
Metaviral_G 268..424 CDD:118131 36/161 (22%)
Peptidase_S64 285..>446 CDD:285411 37/166 (22%)
PRK08581 326..>699 CDD:236304 75/377 (20%)
NPIP 1120..>1320 CDD:283949 43/220 (20%)
Tropomyosin_1 1179..1342 CDD:289488 34/166 (20%)
COG1340 1262..1541 CDD:224259 50/283 (18%)
DUF4795 1300..1496 CDD:292662 33/195 (17%)
AAA_23 <1424..1535 CDD:290211 25/111 (23%)
G_path_suppress 1461..1728 CDD:292610 55/267 (21%)
NPIP <1492..1658 CDD:283949 36/166 (22%)
PROL5-SMR <1647..1733 CDD:292254 12/85 (14%)
PROL5-SMR <1759..>1815 CDD:292254 15/83 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170594695
Domainoid 1 1.000 135 1.000 Domainoid score I4944
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 135 1.000 Inparanoid score I4562
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm25275
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23158
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4780
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
98.980

Return to query results.
Submit another query.