DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango1 and Spz1

DIOPT Version :9

Sequence 1:	NP_609058.2	Gene:	Tango1 / 33930	FlyBaseID:	FBgn0286898	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_001019468.1	Gene:	Spz1 / 499510	RGDID:	1562395	Length:	400	Species:	Rattus norvegicus

Alignment Length:	329	Identity:	57/329 - (17%)
Similarity:	117/329 - (35%)	Gaps:	113/329 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   442 VAQSDAEIKAPSESVISSTTPAPVVEEAPQKAD------PVGLPPLFEKKNFENPNNYYKQLQEE 500
            :|.||:..:.|:.|  .|.:|.|..::.|....      .:|..|.|...:|..|||....::::
  Rat     1 MADSDSSSEMPAHS--PSPSPIPCAKQKPPNTGITISLLEIGSLPTFCCSSFSEPNNNMCPIRKQ 63

  Fly   501 QEKQRL-------------VAEAEEQKR---------LQEEA--------DQQKRL--------- 526
            .:.|:.             :|..||:..         :.|:.        |::.:|
  Rat    64 GKVQKFSNLLKDVKDVLKNIAGFEEKTTDGDPFDDTYIPEDLSELNIRGFDKRNKLRFKDDLFIH 128

  Fly   527 ---QEEAALNKRLLEEAEQQKRLQEE------AEQQKRLQEEAELN------------------- 563
               :.|..:.:.:|.::...|.:.::      ..::||..:..:||
  Rat   129 FDPERENTMRQEMLFKSHSAKNMVQKFARDLCNSEEKRGCDGVQLNAKRRRTGSVHIRGEYRKLR 193

  Fly   564 ---KRLLEEAEKQKRLHEESEQLQRSSEEAEPQLSVQEANMQQLNDSVD-------SQSNEIVDN 618
               ::||:||:...:.|.|..:|.||.:|..          :::.|.||       :|:|..|.:
  Rat   194 NNMEQLLQEADHWSKQHNELSELMRSYQECH----------KEIKDIVDCSRVCSQTQNNNEVPS 248

  Fly   619 NNR--QQPEQYQQHHH--HTESAFNHPSTASHTTPTPDAESPYAAVQEETTEASQTDNHREGVGY 679
            ..:  :|.::..|..|  |..:|.              .|:....:|:......:...|..|.|:
  Rat   249 KQKLEEQVKKLSQDTHSLHLIAAL--------------LENECQILQQRVDILRELHLHEAGPGH 299

  Fly   680 VEPV 683
            .:|:
  Rat   300 EKPL 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango1	NP_609058.2	SH3	42..113	CDD:302595
		GBP_C	<495..585	CDD:303769	21/159 (13%)
		PKK	496..606	CDD:289257	24/179 (13%)
		coiled coil	560..571	CDD:293879	5/32 (16%)
		Drf_FH1	<1291..1337	CDD:283903
Spz1	NP_001019468.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		8/27 (30%)
		PHA02896	<66..213	CDD:165222	19/146 (13%)
		Helix-loop-helix motif. /evidence=ECO:0000255	116..127		1/10 (10%)
		Basic motif. /evidence=ECO:0000255	128..193		7/64 (11%)
		Leucine-zipper	252..273		5/34 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..332		3/9 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352746
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930