Protein Alignment Tango1 and CTAGE15

DIOPT Version :10

• Sequence 1: NP_609058.2
• Gene: Tango1 / 33930
• FlyBaseID: FBgn0286898
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: NP_001008747.1
• Gene: CTAGE15 / 441294
• HGNCID: 37295
• Length: 777
• Species: Homo sapiens
• Alignment Length: 753
• Identity: 169/753 - (22%)
• Similarity: 294/753 - (39%)
• Gaps: 176/753 - (23%)

  Fly   794 SQLLLC-VVIAAISSLFFMFAYY------CFCNSSQE-GALLS-----KLNHLER-SLLASHKEN 844
            |:|::| .||.....|.|::..:      .:....|: ||.||     |...||: ||:....|.
Human    41 SELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEG 105

  Fly   845 LIIKHDLMTTRTKLASIEDNSFGSNDMVADLKKQLESELYEK-----AKLQEQVGSLERDLDNAA 904
            ..::          :|:||.||  ....|:..:.||:.. ||     ::|::::..||:||....
Human   106 YEVE----------SSLEDASF--EKAAAEEARSLEATC-EKLNRSNSELEDEILCLEKDLKEEK 157

  Fly   905 EAGLELNKMLSEVLNGQNGDEAFMSTVDE---LQRQLND-----------QEKIIIEINNSLAEK 955
            ....:.:::::::      .::..|..||   |:.|:.:           :|:..|.|.::|
Human   158 SKHSQQDELMADI------SKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDAL--- 213

  Fly   956 SRENSELQYTFTE-----------ATTRLNSELKTLQEDNYELEMEKSKLQTRLQEIQAETE--S 1007
             .|||:||.:..:           ..:.||.:..|.::.....|...:..:..::.:.....  .
Human   214 -NENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMK 277

  Fly  1008 ELAKALEARNYEMQKLQNQIVELTVKWEREHGDLQTSLAKIEALEDCLKAVGKDAIHNVQELITS 1072
            :.|..||....:...|:   :|:..:||....           |:|.||...|..||..:..::.
Human   278 DQAAVLEEDTTDDDNLE---LEVNSQWENGAN-----------LDDPLKGALKKLIHAAKLNVSL 328

  Fly  1073 AKTRGELNAVHKKLVELQSKVEQEEAHKQRLESQLQQSSQDVEQLKQDFNQSERDKLEAQTRLEV 1137
            ....||.|.:..:|.|:....|:...|.:.|  |.||:|...|.:   :.:||..||  |.:|::
Human   329 KSLEGERNHIIIQLSEVDKTKEELTEHIKNL--QTQQASLQSENI---YFESENQKL--QQKLKI 386

  Fly  1138 LSGYFREKENDLKKELSLQETKWLQHQGENASTVETQTLMKNE-IQTLKSQNDELRAEIEAQIAS 1201
            ::.:::|.|..|.::|:::|...::.: |..|.||.:.....| ::|.:....:|..|:|..:..
Human   387 MTEFYQENEMKLYRKLTVEENYRIEEE-EKLSRVEEKLSRATEQLETYRKLAKDLEEELERTVHF 450

  Fly  1202 HKAQMGTLENRAHESWLAARQSERRCEEALAEAASLRRKLTTMASGGGGVGGDPGVMEAIAANGT 1266
            ::.|:.:.|.|.|::|||||.:||...:...|.|..::|||........:..||..::.    ..
Human   451 YQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDV----SN 511

  Fly  1267 SVLGAE-LKTAPSPLPLPGSPLLNMPNPLPFLAAPFSPFMGLPPPFLPPTGAGGARPP--PLGRM 1328
            :..|.| ....|:||....|......:|...|..|    :|| .|.||..|..|.|.|  ||...
Human   512 TAFGREHAPNGPAPLGQRSSETRAFLSPQTLLEDP----LGL-SPVLPEGGGRGPRGPGNPLDHQ 571

  Fly  1329 RSPPPSSRGDRDRERYSD----YSDYDDYDDDEEDDRGM----------DRR---RRHSGSWGRR 1376
            .:   :.||:...:|.:|    .||........|.|..|          |..   :|....:...
Human   572 IT---NERGEPSCDRLTDPHRAPSDTGSLSSPVEQDCKMMFPPPGQSYPDSALPPQREDRFYSNS 633

  Fly  1377 HRGSYSHSPRTYRSLS--------PSDSRYNYNDTETD---------------------FSP--- 1409
            .|.|.|..||:::..|        ||:...:.||.:.|                     |.|
Human   634 ERLSGSAEPRSFKMTSLDKMDGSMPSEMESSRNDAKDDLGNLNVPDSSLPAENEATGPGFIPPPL 698

  Fly  1410 --------------------PPSPPPVPSGRSATSRPY 1427
                                ||.|||.|......||.|
Human   699 APVRGPLFPVDTRGPFMRRGPPFPPPPPGTMFGASRGY 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tango1	NP_609058.2	SH3	42..113	CDD:473055
		PTZ00121	<191..672	CDD:173412
		Smc	<495..>623	CDD:440809
		SMC_prok_B	854..>1197	CDD:274008	79/375 (21%)
		CwlO1	1078..>1335	CDD:443091	70/260 (27%)
CTAGE15	NP_001008747.1	PRK03918	<86..>507	CDD:235175	104/465 (22%)
		PHA03247	<512..775	CDD:223021	53/233 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	541..671		34/137 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	721..742		7/16 (44%)