DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tango1 and MIA2

DIOPT Version :9

Sequence 1:	NP_609058.2	Gene:	Tango1 / 33930	FlyBaseID:	FBgn0286898	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	XP_024305360.1	Gene:	MIA2 / 4253	HGNCID:	18432	Length:	1426	Species:	Homo sapiens

Alignment Length:	1637	Identity:	333/1637 - (20%)
Similarity:	569/1637 - (34%)	Gaps:	516/1637 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LALVLGLLICCLPTLTWAATLSDKRLCADPKCEQIISMGIAKITYAIGGEGLISFKINSPIRVLS 81
            |.|.:.|..|    |.....|:|.:.|.|.:||.:|:...|...|.......::|.....|.|..
Human    10 LLLAISLTKC----LESTKLLADLKKCGDLECEALINRVSAMRDYRGPDCRYLNFTKGEEISVYV 70

  Fly    82 KSAGSNMQLWGVDINGRRGYANKDFIMEKKILV--------RDKDLLYEVPV------------- 125
            |.||....||........||..:|.:..:::.:        ::.|.|..:.|
Human    71 KLAGEREDLWAGSKGKEFGYFPRDAVQIEEVFISEEIQMSTKESDFLCLLGVSYTFDNEDSELNG 135

  Fly   126 -----VGPGSPVQSVETPVQSVETTVQPVLNAS-------------ESTDDLATTTTSP--LEIA 170
                 :.|....:..::.:...:..::|...|:             |:.:|:.:|:.|.  .|:.
Human   136 DYGENIYPYEEDKDEKSSIYESDFQIEPGFYATYESTLFEDQVPALEAPEDIGSTSESKDWEEVV 200

  Fly   171 VDSIVVEHDKLQDQQVPDPTAAS-----------KAQVQVIEGTELPLEAIAATTEGSIVPETAA 224
            |:|  :|.|::.:..||..:|.|           :|:.:..|....|::. ::.....|..|...
Human   201 VES--MEQDRIPEVHVPPSSAVSGVKEWFGLGGEQAEEKAFESVIEPVQE-SSFRSRKIAVEDEN 262

  Fly   225 DPQEATNLDSTVVDTKEPQALNSEAIKLQEEPKAQQPATEAEKPPPLPQA-------INAELEDA 282
            |.:|..|.:.   .|:..|...||   :...||.|.......:..|.||:       ..:.|
Human   263 DLEELNNGEP---QTEHQQESESE---IDSVPKTQSELASESEHIPKPQSTGWFGGGFTSYL--- 318

  Fly   283 DDFDYGDDET-------------DDDSQQGSQDNESIV---EIANDNKS--INESIELKP----- 324
               .:||::|             .|.....|.|.|:.|   ||..:.|.  .|:|:.|||
Human   319 ---GFGDEDTGLELIAEESNPPLQDFPNSISSDKEATVPCTEILTEKKDTITNDSLSLKPSWFDF 380

  Fly   325 ----LSVAQLKKTDKV--EDSKDE-----TKEKH---AEMEVSKQEDSSLPTETLNVTALEEQID 375
                |..|..|: ||:  :|.|:|     .:.:|   :|::..|:::    .||:.:...|:|||
Human   381 GFAILGFAYAKE-DKIMLDDRKNEEDGGADEHEHPLTSELDPEKEQE----IETIKIIETEDQID 440

  Fly   376 QKEFPKQVLDAAVELKSSDPLPVEEVTETVAEPPRTIVEDKINEEIVPVSAKIQAKPATVNPTEP 440
            :|                   ||.|.|:.
Human   441 KK-------------------PVSEKTDE------------------------------------ 450

  Fly   441 IVAQSDAEIKAPSESVISSTTPAPVVEEAPQKADPVGLPPLFEKK---NFENPNNYYKQLQEEQE 502
                             |.|.|                   :.||   ||:||.| ::.:.:|.|
Human   451 -----------------SDTIP-------------------YLKKFLYNFDNPWN-FQNIPKETE 478

  Fly   503 ----KQRLVAEAEEQKRLQEEADQQKRLQEEAALNKRLLEEAEQQKRLQEEAEQQKRLQEEAELN 563
                ||.|    ::...::.|...:..:......|.:::        :.:.:.....:....||.
Human   479 LPFPKQIL----DQNNVIENEETGEFSIDNYPTDNTKVM--------IFKSSYSLSDMVSNIELP 531

  Fly   564 KRLLEEAEKQKRLHEESEQLQRSSEEAE-PQLSVQEANMQQ--LNDSVDSQSNEIVDNNNRQQPE 625
            .|:.||...:....::|::..:.|.:.| |.|...:.:::.  ||..:.|..|.:...|...|.|
Human   532 TRIHEEVYFEPSSSKDSDENSKPSVDTEGPALVEIDRSVENTLLNSQMVSTDNSLSSQNYISQKE 596

  Fly   626 QYQQH-----------HHHTESAFNHPSTASHTTPTPDAESPYAAVQEETTEASQTDNHREGVGY 679
            ...:.           :....|||                ||...:.|...
Human   597 DASEFQILKYLFQIDVYDFMNSAF----------------SPIVILTERVV-------------- 631

  Fly   680 VEPVALPATASPVSEV-----PIKEDAAGFGLFATIVDTVNNFIGKDPQSDPADSSDELHRILYP 739
               .|||....|.|.:     .:...||..|.||.:.     |:.:..:|        :...||.
Human   632 ---AALPEGMRPDSNLYGFPWELVICAAVVGFFAVLF-----FLWRSFRS--------VRSRLYV 680

  Fly   740 GRPE---------VPPSQRKAEDFA--PADVDGYCARFQAKDEHCHRSISLDNFVEVMADKLVDH 793
            ||.:         :....:..|.|:  ..:.:||......||....:..:....:||.....|:.
Human   681 GREKKLALMLSGLIEEKSKLLEKFSLVQKEYEGYEVESSLKDASFEKEATEAQSLEVENQMFVEG 745

  Fly   794 SQLLLCVVIAAISSLFFMFAYYCFCNSSQEGALLSKLNHLERSLLASHKENLIIKHDLMTTRTKL 858
            ||:                          ..|...|||   ||......|.|.::.:|...::|.
Human   746 SQI--------------------------SEATCEKLN---RSNSELEDEILCLEKELKEEKSKH 781

  Fly   859 ASIEDNSFGSNDMVADLKKQLESELYEKAKLQEQVGSLERDLDNAAEAGLELNKMLSEVLNGQNG 923
            :.       .::::||:.|:::|...|...|:.||          |||     ||..::.
Human   782 SE-------QDELMADISKRIQSLEDESKSLKSQV----------AEA-----KMTFKIF----- 819

  Fly   924 DEAFMSTVDELQRQLNDQEKIIIEINNSLAEKSRENSELQYTFTEATTRLNSELKTLQEDNYELE 988
                         |:| :|::.|.|.::|    .|||:||    |:..:|..|.:..:|...||.
Human   820 -------------QMN-EERLKIAIKDAL----NENSQLQ----ESQKQLLQEAEVWKEQVSELN 862

  Fly   989 MEK-----SKLQTRLQEIQAETESELAKALEARNYEMQK---------LQNQIVELTVKWEREHG 1039
            .:|     ||:..  :::..:.||.: |.|..|..:|:.         ..:..:||.:..|.|:|
Human   863 KQKVTFEDSKVHA--EQVLNDKESHI-KTLTERLLKMKDWAAMLGEDITDDDNLELEMNSESENG 924

  Fly  1040 DLQTSLAKIEALEDCLKAVGKDAIHNVQELITSAKT-RGELNAVHKKLVELQSKVEQEEAHKQRL 1103
                     ..|::..|...|..|| ..:|..|.|| .||.|.::.:|.|:....|:...|.:.|
Human   925 ---------AYLDNPPKGALKKLIH-AAKLNASLKTLEGERNQIYIQLSEVDKTKEELTEHIKNL 979

  Fly  1104 ESQLQQSSQDVEQLKQDFNQSERDKLEAQTRLEVLSGYFREKENDLKKELSLQETKWLQHQGENA 1168
              |.:|:|     |:.:....|.:..:.|.:|:|::..::|.|..|.::|:::|...|:.:.:.:
Human   980 --QTEQAS-----LQSENTHFENENQKLQQKLKVMTELYQENEMKLHRKLTVEENYRLEKEEKLS 1037

  Fly  1169 STVETQTLMKNEIQTLKSQNDELRAEIEAQIASHKAQMGTLENRAHESWLAARQSERRCEEALAE 1233
            ...|..:....|::|.:.:..:|..|:|..|.|::.|:.:.|.:||::|||||.:||...:...|
Human  1038 KVDEKISHATEELETYRKRAKDLEEELERTIHSYQGQIISHEKKAHDNWLAARNAERNLNDLRKE 1102

  Fly  1234 AASLRRKLTTMASGGGGVGGDPGVMEAIAANGTSVLGAELKT-APSPLPLPGSPLLNMPNPLPFL 1297
            .|..|:|||........:..||..::.    ..:..|.|... .||||..|.|......:|...|
Human  1103 NAHNRQKLTETELKFELLEKDPYALDV----PNTAFGREHSPYGPSPLGWPSSETRAFLSPPTLL 1163

  Fly  1298 AAPFSPFMGLPPPFLPPTGAGGARPP--PLGRMRSPPPSSRGDRDRERYSD----YSDYDDYDDD 1356
            ..|..     ..|.||..|..|:|.|  ||....:   :.||:...:|.:|    .||.......
Human  1164 EGPLR-----LSPLLPGGGGRGSRGPGNPLDHQIT---NERGESSCDRLTDPHRAPSDTGSLSPP 1220

  Fly  1357 EEDDRGM----------------DRRRRHSGSWGRRHRGSYSHSPRTYRSLS-----------PS 1394
            .:.||.|                .|:.|...:.||      ...|...||.:           ||
Human  1221 WDQDRRMMFPPPGQSYPDSALPPQRQDRFCSNSGR------LSGPAELRSFNMPSLDKMDGSMPS 1279

  Fly  1395 DSRYNYNDTETD---------------------FSP-----------------------PPSPPP 1415
            :...:.|||:.|                     |.|                       ||.|||
Human  1280 EMESSRNDTKDDLGNLNVPDSSLPAENEATGPGFVPPPLAPIRGPLFPVDARGPFLRRGPPFPPP 1344

  Fly  1416 VPSGRSATSRPY 1427
            .|......||.|
Human  1345 PPGAMFGASRDY 1356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango1	NP_609058.2	SH3	42..113	CDD:302595	18/70 (26%)
		GBP_C	<495..585	CDD:303769	13/93 (14%)
		PKK	496..606	CDD:289257	18/116 (16%)
		coiled coil	560..571	CDD:293879	5/10 (50%)
		Drf_FH1	<1291..1337	CDD:283903	12/47 (26%)
MIA2	XP_024305360.1	SH3_MIA2	31..103	CDD:212825	18/71 (25%)
MIA2	XP_024305360.1	SbcC	<682..>1121	CDD:223496	122/536 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158733
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	185	1.000	Inparanoid score	I3954
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002364
OrthoInspector	1	1.000	-	-		oto91487
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23158
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4780
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.980