DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tango1 and ctage5

DIOPT Version :9

Sequence 1:	NP_609058.2	Gene:	Tango1 / 33930	FlyBaseID:	FBgn0286898	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	XP_021322994.1	Gene:	ctage5 / 393281	ZFINID:	ZDB-GENE-040426-872	Length:	2632	Species:	Danio rerio

Alignment Length:	1390	Identity:	283/1390 - (20%)
Similarity:	488/1390 - (35%)	Gaps:	377/1390 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 EAIAATTEGSIVPET-AADPQEATNL-----DSTVVDTKEPQALN--SEAIKLQEEPKAQQPATE 264
            |::....:|.::..| ..|.....||     |:.|:|.||.|.:.  |:.|...||
Zfish  1341 ESLTNKNDGLVMDSTNGLDMDRNYNLAINRNDNVVMDRKEVQFVEALSKDITFDEE--------- 1396

  Fly   265 AEKPPPLPQAINAELEDADDFDYGDDETDDDSQQGSQDNESIVEIANDNKSINE---SIELKPLS 326
                         :|.|::..|..:::                |::.:..|::|   .|.|:|.|
Zfish  1397 -------------KLPDSEPLDISNED----------------ELSTEINSLDEGRDQIHLEPNS 1432

  Fly   327 VAQLKKTDKVEDSKDETKEKH----AEMEVSKQEDSSLPTETLNVTALEEQIDQKEFPKQVLDAA 387
            .     .:...|..:.|.|.|    .:..:||..||. ...|..|...|||    |.||.|
Zfish  1433 A-----PNTTNDEINNTMESHDGSVEKAGISKDTDSE-RKYTDKVKIHEEQ----EEPKTV---- 1483

  Fly   388 VELKSSDPLPVEEVTETVAEPPRTIVEDKINEEIVPVSAKIQAKPATVNPTEPI-VAQSDA-EIK 450
                 |:|..:|..|       :.|.||..|:           ...|.|.:|.. |:::|. ::.
Zfish  1484 -----SEPTEIEFET-------KEIKEDTHNK-----------NGYTTNTSEGFGVSKNDGHDLD 1525

  Fly   451 AP------------SESVISSTTPAPVVEEAPQKADPVGLPPLFEKKNFENPNNY--YKQLQEEQ 501
            .|            |....:||.| .:......|.:||          .::..||  ..|.|..:
Zfish  1526 IPEKTDNGNIFNTDSNGHKASTEP-NLTSHFFSKEEPV----------LDDSTNYITLDQNQTVE 1579

  Fly   502 EKQRLVAEAEEQKRLQEEADQQKRLQEEAALNKRLLEEAEQQKRLQEEAEQQKRLQEEAELNKRL 566
            .|:....:...|.:.:....::||   :..:......:|:.....|:|.|:|....:..:.....
Zfish  1580 HKEETANDDNHQTKSEYVRKREKR---DTGVIHVQSNDADMAVHSQDEQEEQLGRPQHKKTFSHS 1641

  Fly   567 LEEAEKQKRLHEESEQLQRSSEEAEPQLSVQEANMQQLNDS--------VDSQSNEI---VDNNN 620
            .|..:..|.||                ..:.|.|:|.|:|.        :||:....   .|||:
Zfish  1642 PENFKVYKNLH----------------FHLSEQNIQDLSDLFGDHKLSWLDSKMENTHTGPDNND 1690

  Fly   621 RQQPEQYQQHHHHTESAFNHPSTASHTTPTPDAESPYAAVQEETTEASQTDNHREGVGYVEPVAL 685
            .::...::|...:...                ..:....:|::.......||::|.....:.:.|
Zfish  1691 LEELSDFEQLLEYYMK----------------MNTKLGLIQQDNRPGEDNDNNKEYPALQKLLTL 1739

  Fly   686 PAT-----ASPVSEVPI------KEDAAGFGLFATIVDTV--------NNFIGK--------DPQ 723
            .:|     ::.::::.:      |::...........|||        |..|.:        .||
Zfish  1740 LSTLKKTYSAAIADINVERQGISKDECFHEACLDVNKDTVISSKEVENNPVIAEMSDINDLSSPQ 1804

  Fly   724 SDPADSSDELHRILYPGRPEVPPSQ----RKAEDFAPADVDGYCARFQAK-DEHCHRSISLDNFV 783
            ::|.....|:.    ..|..|...|    ||.||:..:|:....|:.... .|....|.:.:.:.
Zfish  1805 NEPVSQKKEIS----SSRAIVKDVQSEQIRKEEDWTSSDIKKTTAQNHVLFSEELVESQNGEGYF 1865

  Fly   784 EVMADKLVDHSQLLLCVVIAAISSL------------------FFMFAYYCFCNSSQEGALLSKL 830
            ..||..:.|....:..:|:..:|||                  ||                   .
Zfish  1866 YHMAVFVEDTIYEIASIVVKVVSSLPDDIRPGPDLYGLPWEAVFF-------------------T 1911

  Fly   831 NHLERSLLASHKENLIIKHDLMTTRTKLASIEDNSFGSNDMVADLKKQLESELYEKAK------- 888
            ..|..|:|            |:.|...:.||:...:.|.:  ..:..::...|.||.|
Zfish  1912 GFLGLSIL------------LLFTCRFIQSIKSRLYASKE--KQMAHKMAELLDEKCKVLETFSE 1962

  Fly   889 LQEQVGSLERDLDN------AAEAG-LELNKMLSEVLNGQNGDEAFMSTVDELQRQLNDQEKIII 946
            ::::...||..|.|      |||.. ||:.....|..|.|...|     ::.||.:|:.|.|
Zfish  1963 VKQKFDKLESTLQNNGMSARAAEKDTLEVASQKLEQSNAQMKKE-----IERLQEELSQQNK--- 2019

  Fly   947 EINNSLAEKSREN--SELQYTFTEATTRLNSELKTLQEDNYELEMEKSKLQTRLQEIQAETESEL 1009
                  |.|.:|:  :||:................|::||..|::.:...: |||:.....:.|.
Zfish  2020 ------ARKQQEDQLAELEQILRNLEEEAKERKSQLEQDNTTLKIHEINTE-RLQKNLLAAKEEH 2077

  Fly  1010 AKALEARNYEMQKLQ------NQIVELTVKWEREHGDLQTSLA----KIEALEDCL--------- 1055
            ...||::...||:.:      :::.|.....||.|..:....|    :|::|.:||
Zfish  2078 TMLLESKEQLMQEAEGWGERLSELEEEMKMCERSHAGMMEDCANKDDRIKSLTECLLKMRDWDSE 2142

  Fly  1056 ------------KAVGKDA--IH---NVQELITSAKTRGELNAVHKKLVELQSKVEQEEAHKQRL 1103
                        .|...|:  .|   .||:||.:||...:|.::.:....:.:|:..|...|:.|
Zfish  2143 DETSIDGSTNIAGAANGDSSDFHQKQKVQKLIEAAKMSADLKSLEEDKNRVFAKLADEIKAKEDL 2207

  Fly  1104 ESQLQQSSQDVEQLKQDFNQSERDKLEAQTRLEVLSGYFREKENDLKKELSLQETKWLQHQGENA 1168
            ...::|..:..|.|..:......:..:.|.:|::::..::|.|..|.:.|:::|.:.||.:.:..
Zfish  2208 HEGIKQLEEQKELLVSESANYSSESQKLQQKLQIMTEMYQENELKLHRMLTVEEKERLQKEEKLN 2272

  Fly  1169 STVETQTLMKNEIQTLKSQNDELRAEIEAQIASHKAQMGTLENRAHESWLAARQSERRCEEALAE 1233
            ...:..:|...|:.|.:.:..:|..|::....:.|.|:.:.|.:||::|||||.::|...:...|
Zfish  2273 KAGKKISLAAEELNTYRQRAKDLEDELDRTSQAFKNQISSHEKKAHDNWLAARAADRDLADVKRE 2337

  Fly  1234 AASLRRKLTTMASGGGGVGGDP----GVMEAIAANGTSVL-GAELKTAPSPLPLPGSPLLNMPNP 1293
            .|.||::||           |.    .::|.....|..:. |......||||..|.|......:|
Zfish  2338 NAHLRQRLT-----------DAQFRFDILEKDVREGRPIFRGERSPYGPSPLGRPSSETRTFLSP 2391

  Fly  1294 LPFLAAP--FSP-FMGLPPPFLPPTGAGGARPPPLGR---MRSPPPSSRGDR----DRERYSDYS 1348
            ...:..|  .|| |||      |...:.|...||.|.   .||.|.|..|..    ||||.....
Zfish  2392 PTLMDGPPRLSPQFMG------PGRASRGVVEPPSGGPEFERSGPHSDSGSLSPSWDRERRGPPV 2450

  Fly  1349 DYDDYDDDEEDDRGMDRRRRHSGSW------------GRRHRGSYSHSP--RTYRSLSPSDSRYN 1399
            .    ......|.|:..||...|.:            ..::.|..|.|.  |...|:|..:.|..
Zfish  2451 P----PGHPLPDPGLPYRRPPPGPYPMGPLPPRPPLPPEQYFGDKSDSSFLRNSSSISEHEGREG 2511

  Fly  1400 YNDTETDFSPP-------PSPPPVP 1417
            ..|...   ||       |.|||.|
Zfish  2512 SGDMRL---PPDPDSRMGPLPPPGP 2533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango1	NP_609058.2	SH3	42..113	CDD:302595
		GBP_C	<495..585	CDD:303769	15/89 (17%)
		PKK	496..606	CDD:289257	19/109 (17%)
		coiled coil	560..571	CDD:293879	1/10 (10%)
		Drf_FH1	<1291..1337	CDD:283903	16/51 (31%)
ctage5	XP_021322994.1	SH3_MIA2	33..105	CDD:212825
		MDN1	<257..730	CDD:331582
		MDN1	<528..987	CDD:331582
		COG2931	<1025..>1295	CDD:225483
		SMC_N	<1937..2319	CDD:330553	84/398 (21%)
		Dendrin	2360..>2442	CDD:317849	25/87 (29%)
		MISS	<2549..>2603	CDD:318115
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594693
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930