DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tango1 and MIA3

DIOPT Version :9

Sequence 1:NP_609058.2 Gene:Tango1 / 33930 FlyBaseID:FBgn0286898 Length:1430 Species:Drosophila melanogaster
Sequence 2:NP_001310991.1 Gene:MIA3 / 375056 HGNCID:24008 Length:1931 Species:Homo sapiens


Alignment Length:2064 Identity:400/2064 - (19%)
Similarity:653/2064 - (31%) Gaps:811/2064 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 LVLGLLICCLPTLTW----------AATLSDKRLCADPKCEQIISMGIAKITYAIGGEGLISFKI 73
            |::.||:..||   |          ....|:.:||||.:|..::..|.|...:.......::||.
Human     7 LLVWLLVLRLP---WRVPGQLDPSTGRRFSEHKLCADDECSMLMYRGEALEDFTGPDCRFVNFKK 68

  Fly    74 NSPIRVLSKSAGSNMQLWGVDINGRRGYANKDFIM--------EKKILVRDKDLL---------- 120
            ..|:.|..|.|....::|...:....||..||.|.        |.::...:.|.:          
Human    69 GDPVYVYYKLARGWPEVWAGSVGRTFGYFPKDLIQVVHEYTKEELQVPTDETDFVCFDGGRDDFH 133

  Fly   121 -YEV-PVVGPGSPVQSVETPVQ-SVETTVQ-----PVLNA--------------------SESTD 157
             |.| .::|......|..|..: :||.|:|     |.|:.                    ||:|:
Human   134 NYNVEELLGFLELYNSAATDSEKAVEKTLQDMEKNPELSKEREPEPEPVEANSEESDSVFSENTE 198

  Fly   158 DLATTTTSPLEIAVDSIVVEH------------DKLQDQ-QVPDPTAASKAQVQVIEGTELPLEA 209
            ||....|:....:..:....|            :.|||: :||:......:....:...:..::|
Human   199 DLQEQFTTQKHHSHANSQANHAQGEQASFESFEEMLQDKLKVPESENNKTSNSSQVSNEQDKIDA 263

  Fly   210 I----------AATTEGSIVPETAADPQEATNLDSTVVDTKEPQALNSEAIKLQEEPKAQQ---- 260
            .          ..|..||......:| .|.|.|.:::.|..: :.|::|...:.:|.:..|    
Human   264 YKLLKKEMTLDLKTKFGSTADALVSD-DETTRLVTSLEDDFD-EELDTEYYAVGKEDEENQEDFD 326

  Fly   261 ---------------PATEAEKPPPLPQAINAELEDA-----------DDFD----YGD------ 289
                           ||....:..|..:..|:..||.           ||.:    :||      
Human   327 ELPLLTFTDGEDMKTPAKSGVEKYPTDKEQNSNEEDKVQLTVPPGIKNDDKNILTTWGDTIFSIV 391

  Fly   290 ---DETDD----------------------DSQQGS-------------QDNESIVEI--ANDNK 314
               :||.|                      ||:||.             .|...||:|  .|::|
Human   392 TGGEETRDTMDLESSSSEEEKEDDDDALVPDSKQGKPQSATDYSDPDNVDDGLFIVDIPKTNNDK 456

  Fly   315 SIN----------------------------------------ESIELKPLSVAQLKKTDKVEDS 339
            .:|                                        .|..|..:..|: |..|.::.:
Human   457 EVNAEHHIKGKGRGVQESKRGLVQDKTELEDENQEGMTVHSSVHSNNLNSMPAAE-KGKDTLKSA 520

  Fly   340 KDETKE--KHAEMEVSK---QEDSSLPTETLNVTALEEQIDQKEFPKQVLDAAVELKSSDPLPV- 398
            .|:|:.  |.|.:.:||   .|:.  |.|.:.....|.:..||....|:.|..::.:|....|: 
Human   521 YDDTENDLKGAAIHISKGMLHEEK--PGEQILEGGSESESAQKAAGNQMNDRKIQQESLGSAPLM 583

  Fly   399 ------------------------------------EEVTETVAEPPRTIVEDKIN-----EEIV 422
                                                ||:.......||....|:|:     |:.|
Human   584 GDDHPNASRDSVEGDALVNGAKLHTLSVEHQREELKEELVLKTQNQPRFSSPDEIDLPRELEDEV 648

  Fly   423 PV---------------------SAKI-----QAK------------------------------ 431
            |:                     |.||     :||                              
Human   649 PILGRNLPWQQERDVAATASKQMSEKIRLSEGEAKEDSLDEEFFHHKAMQGTEVGQTDQTDSTGG 713

  Fly   432 PATVN-------PTEPIV--------------------AQSDAEIKAPSESVISSTTPAPVVEEA 469
            ||.::       |:|.::                    .|.|..::.|..:|:.:..|.|.:||:
Human   714 PAFLSKVEEDDYPSEELLEDENAINAKRSKEKNPGNQGRQFDVNLQVPDRAVLGTIHPDPEIEES 778

  Fly   470 PQKADPV------------GL--------------PPLFEKKN---------------------- 486
            .|:...:            |:              .||.:||.                      
Human   779 KQETSMILDSEKTSETAAKGVNTGGREPNTMVEKERPLADKKAQRPFERSDFSDSIKIQTPELGE 843

  Fly   487 -FENPNNYYKQLQEEQEKQR---LVAEAEEQKRLQEEADQQKRL----QEEAALNKR-------- 535
             |:|.::.|.:....:|..:   |..|.|.:...::..:.:|.:    |..||....        
Human   844 VFQNKDSDYLKNDNPEEHLKTSGLAGEPEGELSKEDHENTEKYMGTESQGSAAAEPEDDSFHWTP 908

  Fly   536 --LLEEAEQQKR-----LQEEAEQQKRLQ------EEAELNKRLLEEAEKQKRLHEES------- 580
              .:|.....||     :....::|:.||      ...||...|.|.:.|.|...:||       
Human   909 HTSVEPGHSDKREDLLIISSFFKEQQSLQRFQKYFNVHELEALLQEMSSKLKSAQQESLPYNMEK 973

  Fly   581 --EQLQRSSEE-----AEPQLSVQEANMQQLNDSVDSQSNEIVDNNNRQQPEQYQQHHHHTESAF 638
              :::.|:||.     ||..|..:.|..:.|..:.::...|....::.|....:.::.|      
Human   974 VLDKVFRASESQILSIAEKMLDTRVAENRDLGMNENNIFEEAAVLDDIQDLIYFVRYKH------ 1032

  Fly   639 NHPSTASHTTP---TPDAESPYAAVQEETTEASQTDNHREGVGYV------EPVAL------PAT 688
               |||..|..   .|..|.......||.....:.:..||....:      ||..|      ...
Human  1033 ---STAEETATLVMAPPLEEGLGGAMEEMQPLHEDNFSREKTAELNVQVPEEPTHLDQRVIGDTH 1094

  Fly   689 ASPVSEVPIKEDAAGFGLFATIVDTVNNFI--GKDPQS---DPADSSDELHRIL-------YPGR 741
            ||.||:.|..|.....|. .|..||..:.|  .|.|::   :||..:...:.||       |..:
Human  1095 ASEVSQKPNTEKDLDPGP-VTTEDTPMDAIDANKQPETAAEEPASVTPLENAILLIYSFMFYLTK 1158

  Fly   742 PEV---PPSQRKAEDF-----APADVDGY--CARFQAKDEHCHRSISLDNFVEVMADKLVDHSQL 796
            ..|   |...:...||     .|..:..:  .|.|         :|.|...|.|:.|::...::.
Human  1159 SLVATLPDDVQPGPDFYGLPWKPVFITAFLGIASF---------AIFLWRTVLVVKDRVYQVTEQ 1214

  Fly   797 LLCVVIAAISSLFFMFAYYCFCNSSQEGALLSKLNHLERSLLAS-------HKENLIIKHDLMTT 854
            .:...:..|              ..:...|:.||::.|:.:..|       .|:|:|:..:.:..
Human  1215 QISEKLKTI--------------MKENTELVQKLSNYEQKIKESKKHVQETRKQNMILSDEAIKY 1265

  Fly   855 RTKLASIEDNSFGSNDMVADLKKQLESELYEKAKLQEQVGSLERDLDNAAEAGLELNKMLSEVLN 919
            :.|:.::|.|....:|...:|:..||||..:..|.|:.:..               ||...|.| 
Human  1266 KDKIKTLEKNQEILDDTAKNLRVMLESEREQNVKNQDLISE---------------NKKSIEKL- 1314

  Fly   920 GQNGDEAFMSTVDELQRQLNDQEKIIIEINNSLAEKSRENSELQYTFTEA---TTRLNSELKTLQ 981
                                   |.:|.:|.|      |.||:|....||   ..::.||...:|
Human  1315 -----------------------KDVISMNAS------EFSEVQIALNEAKLSEEKVKSECHRVQ 1350

  Fly   982 EDNYELEMEKSKLQTRLQEIQAETESELAKALEARNYEMQKLQNQIVELTVKWEREHGDLQTSLA 1046
            |:|..|:.:|.:||   |||:                :..||..::.|....:|:...||:.:|.
Human  1351 EENARLKKKKEQLQ---QEIE----------------DWSKLHAELSEQIKSFEKSQKDLEVALT 1396

  Fly  1047 ----KIEALEDCLKAV---------------GKDA----------------IHNVQELITSAKTR 1076
                .|.||.:|:..:               |.|:                .:.:::::..::|:
Human  1397 HKDDNINALTNCITQLNLLECESESEGQNKGGNDSDELANGEVGGDRNEKMKNQIKQMMDVSRTQ 1461

  Fly  1077 GELNAVHKKLVELQSKVEQEEAHKQRLESQLQQSSQDVEQLKQDFNQSERDKL----EAQT---R 1134
            ..::.|.:.|..||.|:....:.|..||.|       |::|:.|.|..:..|.    |.:|   :
Human  1462 TAISVVEEDLKLLQLKLRASVSTKCNLEDQ-------VKKLEDDRNSLQAAKAGLEDECKTLRQK 1519

  Fly  1135 LEVLSGYFREKENDLKKELSLQETKWLQHQGENASTVETQTLMKNEIQTLKSQNDELRAEIEAQI 1199
            :|:|:..:::||..|:|:||.:|.:..:.:...::..|.......|::|.|.:.:|:..|::...
Human  1520 VEILNELYQQKEMALQKKLSQEEYERQEREHRLSAADEKAVSAAEEVKTYKRRIEEMEDELQKTE 1584

  Fly  1200 ASHKAQMGTLENRAHESWLAARQSERRCEEALAEAASLRRKLTTM-------------------- 1244
            .|.|.|:.|.|.:|||:||.||.:||...|...|||:||.||..:                    
Human  1585 RSFKNQIATHEKKAHENWLKARAAERAIAEEKREAANLRHKLLELTQKMAMLQEEPVIVKPMPGK 1649

  Fly  1245 ----------------------ASGG-----------------------------GGVGG----- 1253
                                  .|||                             |.|.|     
Human  1650 PNTQNPPRRGPLSQNGSFGPSPVSGGECSPPLTVEPPVRPLSATLNRRDMPRSEFGSVDGPLPHP 1714

  Fly  1254 -------------DPGVMEAIAANGTS-------VLG---------AELKTAPS----------- 1278
                         |||...|...|.:|       ||.         .|:.:.||           
Human  1715 RWSAEASGKPSPSDPGSGTATMMNSSSRGSSPTRVLDEGKQTVLQEPEVPSVPSITSLAERPVAV 1779

  Fly  1279 ------PLPLPGSPLLNMP-----------NPLPFLAAPFSPFMGLPPPFLPPTGAGGARPPPLG 1326
                  |.|.||.||::.|           .|.|.|..||.| ..|||||.|     |.| ||||
Human  1780 NMAPKGPPPFPGVPLMSTPMGGPVPPPIRYGPPPQLCGPFGP-RPLPPPFGP-----GMR-PPLG 1837

  Fly  1327 RMRSPPPSSRGDRDRERYSDYSDYDDYDDDEEDDRGM---DRRRRHSGSWGRRHRGSY------- 1381
            .....|....|.||...:               .||.   ....|..||.|.|   .|       
Human  1838 LREFAPGVPPGRRDLPLH---------------PRGFLPGHAPFRPLGSLGPR---EYFIPGTRL 1884

  Fly  1382 ---SHSPRTY------RSLSPSDSRYNYNDTETDFSPPPSPPPVPSGRS 1421
               :|.|:.|      |.|.||.||             ..|||.....|
Human  1885 PPPTHGPQEYPPPPAVRDLLPSGSR-------------DEPPPASQSTS 1920

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tango1NP_609058.2 SH3 42..113 CDD:302595 20/78 (26%)
GBP_C <495..585 CDD:303769 22/126 (17%)
PKK 496..606 CDD:289257 30/151 (20%)
coiled coil 560..571 CDD:293879 4/10 (40%)
Drf_FH1 <1291..1337 CDD:283903 20/56 (36%)
MIA3NP_001310991.1 SH3_MIA3 37..109 CDD:212826 19/71 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 155..258 18/102 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 314..378 10/63 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 390..601 35/213 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 659..918 35/258 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1093..1121 10/28 (36%)
NPIP 1160..>1370 CDD:283949 58/296 (20%)
Mediates interaction with MIA2. /evidence=ECO:0000269|PubMed:21525241 1211..1650 113/523 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1420..1443 2/22 (9%)
NPIP <1458..1697 CDD:283949 57/245 (23%)
Drf_FH1 1710..1914 CDD:283903 58/241 (24%)
SEC16A-interacting region (SIR), required for its localization to endoplasmic reticulum exit sites and for its interaction with SEC16A. /evidence=ECO:0000269|PubMed:28442536 1812..1871 24/80 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165158738
Domainoid 1 1.000 149 1.000 Domainoid score I4438
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 185 1.000 Inparanoid score I3954
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23158
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4780
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
87.980

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