Protein Alignment Tango1 and CTAGE6

DIOPT Version :10

• Sequence 1: NP_609058.2
• Gene: Tango1 / 33930
• FlyBaseID: FBgn0286898
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: NP_848656.2
• Gene: CTAGE6 / 340307
• HGNCID: 28644
• Length: 777
• Species: Homo sapiens
• Alignment Length: 748
• Identity: 167/748 - (22%)
• Similarity: 296/748 - (39%)
• Gaps: 166/748 - (22%)

  Fly   794 SQLLLC-VVIAAISSLFFMFAYY------CFCNSSQE-GALLS-----KLNHLER-SLLASHKEN 844
            |:|::| .||.....|.|::..:      .:....|: ||.||     |...||: ||:....|.
Human    41 SELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEG 105

  Fly   845 LIIKHDLMTTRTKLASIEDNSFGSNDMVADLKKQLESELYEK-----AKLQEQVGSLERDLDNAA 904
            ..::          :|:||.||  ....|:..:.||:.. ||     ::|::::..||:||....
Human   106 YEVE----------SSLEDASF--EKAAAEEARSLEATC-EKLNRSNSELEDEILCLEKDLKEEK 157

  Fly   905 EAGLELNKMLSEVLNGQNGDEAFMSTVDE---LQRQLND-----------QEKIIIEINNSLAEK 955
            ....:.:::::::      .::..|..||   |:.|:.:           :|:..|.|.::|.|.
Human   158 SKHSQQDELMADI------SKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDALNEN 216

  Fly   956 SRENSELQYTFTEATTRLNSELKTLQEDNYELEMEKSKLQTRLQEIQAETESELAKAL------- 1013
            |:..:..:..|.:.......|:..|.:.  ::..|.||:..  :::..:.|:.: |.|
Human   217 SQLQTSHKQLFQQEAEVWKGEVSELNKQ--KITFEDSKVHA--EQVLNDKENHI-KTLTGHLPMM 276

  Fly  1014 --EARNYEMQKLQNQIVELTVKWEREHGDLQTSLAKIEALEDCLKAVGKDAIHNVQELITSAKTR 1076
              :|...|.....:..:||.|..:.|:|         ..|:|.||...|..||..:..::.....
Human   277 KDQAAVLEEDTTDDDNLELEVNSQWENG---------ANLDDPLKGALKKLIHAAKLNVSLKSLE 332

  Fly  1077 GELNAVHKKLVELQSKVEQEEAHKQRLESQLQQSSQDVEQLKQDFNQSERDKLEAQTRLEVLSGY 1141
            ||.|.:..:|.|:....|:...|.:.|  |.||.|...|.:   :.:||..||  |.:|::::.:
Human   333 GERNHIIIQLSEVDKTKEELTEHIKNL--QTQQESLQSENI---YFESENQKL--QQKLKIMTEF 390

  Fly  1142 FREKENDLKKELSLQETKWLQHQGENASTVETQTLMKNEIQTLKSQNDELRAEIEAQIASHKAQM 1206
            ::|.|..|.::|:::|...::.:.:.:...|..:....:::|.:....:|..|:|..:..::.|:
Human   391 YQEDEMKLYRKLTVEENYRIEEEEKLSKVEEKLSRATEQLETYRKLAKDLEEELERTVHFYQKQV 455

  Fly  1207 GTLENRAHESWLAARQSERRCEEALAEAASLRRKLTTMASGGGGVGGDPGVMEAIAANGTSVLGA 1271
            .:.|.|.|::|||||.:||...:...|.|..::|||........:..||..::.    ..:..|.
Human   456 ISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDV----SNTAFGR 516

  Fly  1272 E-LKTAPSPLPLPGSPLLNMPNPLPFLAAPFSPFMGLPPPFLPPTGAGGARPP--PLGRMRSPPP 1333
            | ....|:||....|......:|...|..|    :|| .|.||..|..|.|.|  ||....:
Human   517 EHAPNGPAPLGQRSSETRAFLSPQTLLEDP----LGL-SPVLPEGGGRGPRGPGNPLDHQIT--- 573

  Fly  1334 SSRGDRDRERYSD----YSDYDDYDDDEEDDRGM----------DRR---RRHSGSWGRRHRGSY 1381
            :.||:...:|.:|    .||........|.|..|          |..   :|....:....|.|.
Human   574 NERGEPSCDRLTDPHRAPSDTGSLSSPVEQDCKMMFPPPGQSYPDSALPPQREDRFYSNSERLSG 638

  Fly  1382 SHSPRTYRSLS--------PSDSRYNYNDTETD---------------------FSP-------- 1409
            |..||:::..|        ||:...:.||.:.|                     |.|
Human   639 SAEPRSFKMTSLDKMDGSMPSEMESSRNDAKDDLGNLNVPDSSLPAENEATGPGFIPPPLAPVRG 703

  Fly  1410 ---------------PPSPPPVPSGRSATSRPY 1427
                           ||.|||.|......||.|
Human   704 PLFPVDTRGPFMRRGPPFPPPPPGTMFGASRGY 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tango1	NP_609058.2	SH3	42..113	CDD:473055
		PTZ00121	<191..672	CDD:173412
		Smc	<495..>623	CDD:440809
		SMC_prok_B	854..>1197	CDD:274008	77/370 (21%)
		CwlO1	1078..>1335	CDD:443091	66/259 (25%)
CTAGE6	NP_848656.2	Mplasa_alph_rch	<133..>503	CDD:275316	86/396 (22%)
		PHA03247	<512..775	CDD:223021	53/233 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	541..671		34/137 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	721..742		7/16 (44%)