DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tango1 and Mia3

DIOPT Version :9

Sequence 1:NP_609058.2 Gene:Tango1 / 33930 FlyBaseID:FBgn0286898 Length:1430 Species:Drosophila melanogaster
Sequence 2:XP_036021859.1 Gene:Mia3 / 338366 MGIID:2443183 Length:1954 Species:Mus musculus


Alignment Length:2093 Identity:393/2093 - (18%)
Similarity:669/2093 - (31%) Gaps:835/2093 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 LALVLGLL--ICCLPTLTW---------AATLSDKRLCADPKCEQIISMGIAKITYAIGGEGLIS 70
            :|...|||  :..|..|.|         ....||.::|.|.:|..::..|.|...:.......::
Mouse     1 MAAAPGLLFWLFVLGALWWVPGQSDLSHGRRFSDLKVCGDEECSMLMYRGKALEDFTGPDCRFVN 65

  Fly    71 FKINSPIRVLSKSAGSNMQLWGVDINGRRGYANKDFI------MEKKILV-------------RD 116
            ||....:.|..|.||.:::||...:....||..||.|      .|:::.:             ||
Mouse    66 FKKGDDVYVYYKLAGGSLELWAGSVEHSFGYFPKDLIKVLHKYTEEELHIPADETDFVCFEGGRD 130

  Fly   117 KDLLYEV-PVVGPGSPVQSV---------------ETPVQSVETTVQPVLNA------------- 152
            ....|.| .::|......||               ::|.:|....:.||...             
Mouse   131 DFNSYNVEELLGSLELEDSVPEESKKAEEVSQHREKSPEESRGRELDPVPEPEAFRADSEDGEGA 195

  Fly   153 -SESTDDLA---------TTTTSP------LEIAVDSI-VVEHDKLQ----DQQVPDPTAAS--- 193
             ||||:.|.         ..|:.|      ::.::|:. .:.||||:    :.:..:.:.||   
Mouse   196 FSESTEGLQGQPSAQESHPHTSGPAANAQGVQSSLDTFEEILHDKLKVPGSESRTGNSSPASVER 260

  Fly   194 -KAQVQVIEGTELPLEAIAATTEGSIVPETAADPQEATNLDSTVVDTKEPQALNSEAIKLQEEPK 257
             |.....:..||:.|:  ..|..||......:| .|||.|.:::.|..: :||::|...::||.:
Mouse   261 EKTDAYKVLKTEMSLD--LKTKFGSTADALVSD-DEATRLVTSLEDGFD-EALDAEYYPMEEEEE 321

  Fly   258 AQQPATEAE----------------KP--------------------PPL--------------- 271
            .::.|..::                ||                    ||.               
Mouse   322 VEEDADSSDELPLLTFSDKDEKVPGKPMIEKYLTDKDPNLSEEDKVEPPTWGDAFFSIVTGGEGK 386

  Fly   272 PQAINAE--LEDADD----------------FDYGDDETDD---------DSQQGSQDNESIVEI 309
            |..::.|  :|:.:|                :...:||.||         |.:....|.|.:  |
Mouse   387 PGVVDLERSIEEEEDVSVSSSHQRKPQPAAGYTDSEDEGDDLFVEEPKTNDVKDSETDPELV--I 449

  Fly   310 ANDNKSINES--------------------------IELKPLSVAQLKK--TDKVEDSKDETKEK 346
            ..:.|.|.||                          .:|.|||.|:..:  |.|....|.|...|
Mouse   450 TGEEKDIQESRKGLVQPESQSEDAKSETASAYRLQGSKLNPLSAAEKGRDFTLKAVFEKKENGLK 514

  Fly   347 HAEMEVSKQ---ED-------SSLPTETLNVTALEEQIDQKEFPKQVLDAAVELKSSDPLPVEEV 401
            .:.:.:||:   ||       .||.:|.:: .||...:.:...||. |..|..|.::.|...::.
Mouse   515 ESVIHISKETLHEDKTREIQRDSLESELVH-RALGSSVTENNKPKS-LGVAPLLGNNKPDASKDS 577

  Fly   402 TETVAEPPRTIVEDKINEE--IVPVSAKIQAKPATVNPTE-----------PIVAQ--------- 444
            ||.   |..::...|..::  .:....|.|.:|....|.|           ||..:         
Mouse   578 TEV---PDGSVSGPKAGQQEGFLEPGLKTQHQPRFSPPEETGPSRELGGKVPISGRNLSWQQEQD 639

  Fly   445 ------------------------SDAE----IKAPSES----VISSTTPAPVVEEAPQKAD--- 474
                                    :|||    |:.|.|:    |:|.....|..||..::.|   
Mouse   640 VAAVVGKHANEKTGFPEEESREDGTDAEQARAIRRPQEAESPEVLSVQPGRPDEEEEEEEGDNYP 704

  Fly   475 PVGL---------------------------PPLFEK----------KNFENPNNYYKQLQEEQE 502
            |.||                           ..:|||          :..:.|.|...:..:|.|
Mouse   705 PEGLMEDENAVSAQQSRENSPSARDGRSDMNSQVFEKVILGTLNLNTEKTKQPANMILETGQESE 769

  Fly   503 K-------------QRLVAEAEEQ-------------KRLQEEA-----------------DQQK 524
            .             ..:|.::||.             ..|::|.                 |.||
Mouse   770 TTSEEAGDVGKESGHSVVVDSEESHLADMRAQRPSQVHGLRDETAAQTPGSGEAVLSKNPNDLQK 834

  Fly   525 RLQEEAALNKRLLE----------EAEQQKR-------------LQEEAEQQ----------KRL 556
            ...||..:|...||          |.|..|.             |:::..:|          |.:
Mouse   835 DNPEEELVNTLGLEDPGVGEISEGEPEDTKEFGVSESQGTDAEDLRDDPSRQATPEIPDIVLKSI 899

  Fly   557 QEE------------------------AELNKRLLEEAEKQKRLHEES---------EQLQRSSE 588
            :|:                        .||...|.:.:.:.:..|:.|         :::.|:||
Mouse   900 REDLPIINSFFKDDQQSLHRFLKYFDVRELEGLLEDMSIRLRSAHQNSLPYNMEKVLDKVFRASE 964

  Fly   589 E-----AEPQLSVQEANMQQLNDSVDS--QSNEIVDNNNRQQPEQYQQHHHHTESAFNHPSTASH 646
            .     ||..|....|..:.|.....|  :..|::|:        .|...:.....::...||..
Mouse   965 SRILSMAEKMLDTGVAKNRDLGSKESSPLEEAEVLDD--------IQDLIYFVRYQYSGVETAPL 1021

  Fly   647 TTPTPDAESPYAAVQEETTEASQTDNHREGVG--YVEPVALPATA-SPVSEVPIKEDAAGFGLFA 708
            .||.|..|. :|...||.....|....:|..|  .|:|...|..: .||:.|             
Mouse  1022 VTPPPPEEG-WARPGEERQPPQQDSLPQENTGDLSVQPPEEPELSDQPVTSV------------- 1072

  Fly   709 TIVDTVNNFIGKDPQSDPADSSDELHRILYPGRPEV---------PPSQRKAEDFAPADVDGYCA 764
                        .|..:|..|...:..:..|..||:         ||.:.:..|   ..|.||.:
Mouse  1073 ------------QPPEEPELSDQPVTSVQPPEEPELSDQPVTSVQPPEEPELSD---QPVTGYTS 1122

  Fly   765 RFQAKDE-HCHRSISL--------------DNFVEVMADK-----------------LVDHSQLL 797
            ..:...: ...:.|.|              ...:|.:|::                 ::..|::|
Mouse  1123 TSEVSQKPDTKKDIDLGPVMEGGPVGAGDVQKQLETIAEEPAAVPPLESAFGSLYAFILYLSKML 1187

  Fly   798 LC-------------------VVIAAISSL--FFMFAYYCFC-------------------NSSQ 822
            |.                   |:|.|:..:  |.:|::....                   |..:
Mouse  1188 LATLPDNVQPGPDFYGLPWQPVIITAVLGIVSFAIFSWRTILVVKSRVYQVTEKQISEKLENIKK 1252

  Fly   823 EGA-LLSKLNHLERSLLAS-------HKENLIIKHDLMTTRTKLASIEDNSFGSNDMVADLKKQL 879
            |.| |:.||:..|:.:..|       .|:|:|:..:.:..:.|:..:|:.:....|....|:.||
Mouse  1253 ENAELMQKLSSYEQKIKESKKYVQETKKQNMILSDEAVKYKDKIKILEETNVSLGDKAKSLRLQL 1317

  Fly   880 ESELYEKAKLQEQVGSLERDLDNAAEAGLELNKMLSEVLNGQNGDEAFMSTVDELQRQLNDQEKI 944
            |||..:..|.|:.:...::.::.           |.:|:: .|..|     :.|:|..||:    
Mouse  1318 ESEREQNVKNQDLILENKKSIEK-----------LKDVIS-MNASE-----LSEVQVALNE---- 1361

  Fly   945 IIEINNSLAEKSRENSELQYTFTEATTRLNSELKTLQEDNYELEMEKSKLQTRLQEIQAETESEL 1009
                    |:.|.||             :.||...:||:|..|:.:|.:||.:::| .:::.:||
Mouse  1362 --------AKLSEEN-------------VKSECHRVQEENARLKKKKEQLQQQVEE-WSKSHAEL 1404

  Fly  1010 AKALEARNYEMQKLQNQIVELTVKWEREHGDLQTSLA----KIEALEDCLKAVGK---------- 1060
            .:.:::                  :|:...||:.:|.    .|.||.:|:..:.:          
Mouse  1405 TEQIKS------------------FEKSQEDLEIALTHKDDNISALTNCITQLNRLECELESEDP 1451

  Fly  1061 --------------------DAIHN-VQELITSAKTRGELNAVHKKLVELQSKVEQEEAHKQRLE 1104
                                :.|.| :::::..::|:..::.|.:.|..||.|:....:.|..||
Mouse  1452 DKGGNESDDLANGETGGDRSEKIRNRIKQMMDVSRTQTAVSIVEEDLKLLQLKLRASMSTKCNLE 1516

  Fly  1105 SQLQQSSQDVEQLKQDFNQSERDKLEAQTRLEVLSGYFREKENDLKKELSLQETKWLQHQGENAS 1169
            .|:::...|...|:......|.:....:.::|:|:..:::||..|:|:||.:|.:....:....:
Mouse  1517 DQIKKLEDDRSSLQTAKAGLEDECKTLRQKVEILNELYQQKEMALQKKLSQEEYERQDREQRLTA 1581

  Fly  1170 TVETQTLMKNEIQTLKSQNDELRAEIEAQIASHKAQMGTLENRAHESWLAARQSERRCEEALAEA 1234
            ..|...|...|::|.|.:.:|:..|::....|.|.|:...|.:||::||.||.:||...|...||
Mouse  1582 ADEKVVLAAEEVKTYKRRIEEMEEELQKTERSFKNQIAAHEKKAHDNWLKARAAERAMAEEKREA 1646

  Fly  1235 ASLRRKLTTM------------------------------------------ASGG--------- 1248
            |:||.||..|                                          .|||         
Mouse  1647 ANLRHKLLEMTQKMAMRQDEPVIVKPMPGRPNTQNPPRRGLLSQNGSFGPSPVSGGECSPPLPAE 1711

  Fly  1249 --------------------GGV------------------GGDPGVMEAIAANGTSVLGAEL-- 1273
                                |.:                  ..|||....:.::..|...|:.  
Mouse  1712 PPGRPLSATLSRRDTPRSEFGSLDRHLPRPRWPSEASGKHSASDPGPAPVVNSSSRSSSPAKAVD 1776

  Fly  1274 ---KTAP--------------------------SPLPLPGSPLLNMPNPLP--------FLAAPF 1301
               :|.|                          .|.|.||.||:..|.|.|        ....||
Mouse  1777 EGKQTVPQEPEGPSASSMAPLAGHPVAVNMAPKGPPPFPGVPLMGGPVPPPIRYGPPPQLCGGPF 1841

  Fly  1302 SPFMGLPPPFLPPTGAGGARPPPLGRMRSPPPSSRGDRD-----RERYSDYSDYDDYDDDEEDDR 1361
            .| ..|||||:|      ...||||.....|....|.||     ||....::.:           
Mouse  1842 GP-RPLPPPFVP------GMHPPLGVREYAPGVLPGKRDLPLDPREFLPGHTPF----------- 1888

  Fly  1362 GMDRRRRHSGSWGRRH---RGSY----SHSPRTYRSLSPSDSRYNYNDTETDFSPPPSPPPV--- 1416
                  |..||.|.|.   .|:.    :|.|:.|                     ||.||.|   
Mouse  1889 ------RPPGSLGPREFFIPGTRLPPPTHGPQEY---------------------PPPPPAVRDS 1926

  Fly  1417 -PSGRSATSRPYS 1428
             |||....::|.|
Mouse  1927 LPSGPREEAKPAS 1939

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tango1NP_609058.2 SH3 42..113 CDD:302595 19/76 (25%)
GBP_C <495..585 CDD:303769 27/198 (14%)
PKK 496..606 CDD:289257 35/223 (16%)
coiled coil 560..571 CDD:293879 3/10 (30%)
Drf_FH1 <1291..1337 CDD:283903 17/53 (32%)
Mia3XP_036021859.1 SH3 38..109 CDD:418401 18/70 (26%)
PRK14949 <716..1119 CDD:237863 72/439 (16%)
PHA03247 <1014..1144 CDD:223021 32/158 (20%)
Mplasa_alph_rch <1239..1625 CDD:275316 89/446 (20%)
PHA03247 <1671..1954 CDD:223021 58/314 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167849134
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 158 1.000 Inparanoid score I4248
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm44202
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23158
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4780
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.020

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