Protein Alignment Tango1 and Mia2

DIOPT Version :9

• Sequence 1: NP_609058.2
• Gene: Tango1 / 33930
• FlyBaseID: FBgn0286898
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: NP_001358270.1
• Gene: Mia2 / 100912115
• RGDID: 6488546
• Length: 1405
• Species: Rattus norvegicus
• Alignment Length: 1562
• Identity: 321/1562 - (20%)
• Similarity: 563/1562 - (36%)
• Gaps: 425/1562 - (27%)

  Fly    17 LALVLGLLICCLPTLTWAATLSDKRLCADPKCEQIISMGIAKITYAIGGEGLISFKINSPIRVLS 81
            |.||:.|..|    |.....|:..:.|.|.:||.:|:..:|...:.......::|.....|.|..
  Rat    10 LLLVISLAKC----LEGTKLLAHLKKCGDLECETLITRVLALRDHTGPDCRYLNFTTGEEISVYV 70

  Fly    82 KSAGSNMQLWGVDINGRRGYANKDFIMEKKILVRDKDLLYEVPVVGPGSPVQSVETPVQSVETTV 146
            |..|....||.    |.:|   |||    ....||...:.||.:      .:.||.|.:..:...
  Rat    71 KLGGDREDLWA----GSKG---KDF----GFFPRDAVEIEEVFI------SEEVEMPTKESDFLC 118

  Fly   147 ---QPVLNASES----TDDLATTTTSPLE--------IAVDSIVVEHD-------KLQDQQVPDP 189
               :..:..||.    :||.......|.|        |..|....|||       .|.:.|:...
  Rat   119 LLGEGYIFGSEQSEFISDDDGEEHMYPYEKDEDQHYNIYEDDFQPEHDFYEASEGSLPEDQISAS 183

  Fly   190 TAAS----KAQVQVIEGTELPLEAIAATTEGSIVPETAADPQEATNLDSTVVDTKEPQALNSEAI 250
            .||.    .::.:..|||         .:||:...:...||.:|  |.|  :.|.|.|......|
  Rat   184 EAAEDFRFSSKWKDWEGT---------ASEGTGEQDYTPDPDQA--LPS--LSTPERQGWFGLGI 235

  Fly   251 KLQEEPKAQQPATEAEKPPPLPQAINAELEDADDFD-------YGDDETDDDSQQGSQDN----- 303
            :..|| |..:|.||..:.... |:....||:..|.:       .|:.|.:..||..|:.:
  Rat   236 EEAEE-KTFEPDTEPTQESSF-QSRKLTLEEESDLEKLHDGEPQGELEQEPKSQFDSETSEFSSA 298

  Fly   304 -ESIVEIANDNKSI--------------------NESIELKPLSVAQLKKTDKVEDSKDETKEKH 347
             |...::|:.::|.                    ||..||:|||                 :|.|
  Rat   299 PEEQFDLASGSESAPNPKASGWFGGGFTSYLGFGNEGAELEPLS-----------------EESH 346

  Fly   348 AEMEVSKQEDSSLPTETLNVTALEEQIDQKEFPKQVLDAAVELKSSDPLPVEEVTETVAEPPRTI 412
                                                            ||:::|
  Rat   347 ------------------------------------------------LPLQDV----------- 352

  Fly   413 VEDKINEEIVPVSAKIQAKPATVNPTEPIVAQSDAEIKAPSESVISSTTPAPVVEEAPQKADPVG 477
                               |:.|:|.|      ||              |||..|.:..|.|.|
  Rat   353 -------------------PSPVSPDE------DA--------------PAPCRETSTVKEDTV- 377

  Fly   478 LPPLFEKKNFENPNNYYKQLQ----EEQEKQRLVAEAEEQKRLQEEADQQKRLQEEAALNKRLLE 538
                ....:..:|:.:|....    ...::.:::::..|.:  ..|.|..|.      ..|...:
  Rat   378 ----VNDSSVLSPSWFYFGFGMLGFTNADEDKIISDNGENE--DGEVDDLKH------PTKNDFD 430

  Fly   539 EAEQQKRLQEEAEQQKRLQEEAELNKRLLEEA---EKQKRLHEESEQLQRSSEEAEPQLSVQEAN 600
            ..::|||..|:     :..:|:.|.|  ::::   :..|:..:.....|...|:.|...|.|..:
  Rat   431 PEKEQKRKTED-----QTGKESTLEK--IDDSGSMQYLKKFFDNPWGFQNRPEDTELPFSKQRLD 488

  Fly   601 MQQLNDSVDSQSNEIVDNNNRQQPEQYQQHHHHTESAFNHPSTASHTTPTPDAESPYAAVQEETT 665
            ...:..|  .::.|::..|:   |....:....:.|.::....||.|      |||....:....
  Rat   489 EDDIVGS--DKTEELLTENS---PTGSMRDSMMSRSRYSLSDVASET------ESPTGVHEGINF 542

  Fly   666 EASQTD-NHREGVGYVEPVALPATASPVSEVPIKEDAAGFGLFATIVDTVNNFIGKDPQSDPADS 729
            ::|.:: |..:...:|:|..|        .|...|...|..|...:|             .|.:.
  Rat   543 KSSSSERNEEDSKSWVDPEEL--------SVAQTESLEGALLETQLV-------------SPNER 586

  Fly   730 SDELHRILYPGRPEVPPSQRKAEDFAPADVDGYCARFQAKDEHCHRSISLDNFVEVM-ADKLVDH 793
            :.|...:.|....:|....|.|  |:|.:                  |.|::.|..: .|...|.
  Rat   587 AAEFQLLKYLLHIDVYSFMRSA--FSPIE------------------ILLESVVAALPEDMRADF 631

  Fly   794 S------QLLLCVV-IAAISSLFFMFAYYCFCNSSQEGALLSKLNHLERSLLASHKENLIIK--- 848
            :      :|.:||: :..::.:.|::..:....|........|| .||.|.|...|..|:.|
  Rat   632 NPNGFSLELAICVLTVGLLAIVLFLWRGFRSIRSRFYVGREKKL-ALELSALIEEKCKLLEKVSF 695

  Fly   849 ----HDLMTTRTKLASIEDNSFGSNDMVADLKKQLESELYE-----KAKLQEQVGSLERDLDNAA 904
                ::.:.:..|.||.|..|..:..:......|:....||     |:||::::..||:.|:...
  Rat   696 VQKEYEGLESSLKEASFEKESTEAQSLEFVEGSQISEAAYENLERSKSKLEDEILLLEKKLEEER 760

  Fly   905 EAGLELNKMLSEVLNGQNGDEAFMSTVDE---LQRQLNDQEKI--IIEIN-----NSLAEKSREN 959
            ....|.:::::::      .:...|..||   |:.|:.:.:..  |.|||     .::.:...||
  Rat   761 VKHSEQDELMADI------SKRIQSLEDESKSLKSQVAEAKTTFRIFEINEERLRGAIKDALNEN 819

  Fly   960 SELQYTFTEATTRLNSELKTLQEDNYELEMEKSKLQTRLQEIQAETESELAKALEARNYEMQKLQ 1024
            |:||    |:..:|..|.:.::|...:|:.:|    ..|:|.:|:.|    :.|..:..:::.|.
  Rat   820 SQLQ----ESQKQLLQEAEIMKEQVSDLDKQK----VTLEESRAQAE----QVLSEKETQIESLI 872

  Fly  1025 NQIVELTVKWEREHG-----------DLQTSLAKIEALEDCLKAVGKDAIHNVQELITSAKT-RG 1077
            ..::::. .|....|           |:::.|....:|::..|...|..|: ..:|..|.|. .|
  Rat   873 KSLLKMK-DWAAVLGDDTADDGNLDLDMKSGLEDTASLDNQPKGALKKLIY-AAKLNASLKALEG 935

  Fly  1078 ELNAVHKKLVELQSKVEQEEAHKQRLESQLQQSSQDVEQLKQDFNQSERDKLEAQTRLEVLSGYF 1142
            |.|.::.:|.|:....|....|.:.|||  :|:|     |:.:..:.|.:....|.:|:|::..:
  Rat   936 ERNQIYTQLSEVDQIKEDLTEHIKSLES--KQAS-----LQSENTEFESESQRLQQKLKVITELY 993

  Fly  1143 REKENDLKKELSLQETKWLQHQGENASTVETQTLMKNEIQTLKSQNDELRAEIEAQIASHKAQMG 1207
            :|.|..|.::|:::|...|:.:.:.:...|..:....|::|.:.:..:|..|:|..|.|::.|:.
  Rat   994 QENEMKLHRKLTVEENYRLEKEEKLSKVDERISHAAEELETYRQRAKDLEEELERTIHSYQGQVI 1058

  Fly  1208 TLENRAHESWLAARQSERRCEEALAEAASLRRKLTTMASGGGGVGGDPGVMEAIAANGTSVLGAE 1272
            :.|.:||::|||||..||...:...|.|..|:|||........:..||..::.    ..:..|.|
  Rat  1059 SHEKKAHDNWLAARTLERNLNDLRKENAHNRQKLTETEFKFELLEKDPYALDV----PNTAFGRE 1119

  Fly  1273 LKT-APSPLPLPGSPLLNMPNPLPFLAAPFSPFMGLPPPFLPPTGAGGARPPPLGRMRSPPPSSR 1336
            ... .||||..|.|......:|...|..|..     ..|.||..|..|:|.|. ..:.....:.|
  Rat  1120 HSPYGPSPLGRPPSETRAFLSPPTLLEGPLR-----LSPLLPGGGGRGSRGPE-NLLDHQMNTER 1178

  Fly  1337 GDRDRERYSDYSDYDDYDDDEEDDRGM----DRRRR----------HSGSWGRRHRGSYSHS--- 1384
            ||...:|.||       ......||.:    ::.||          :|....:|....||:|
  Rat  1179 GDSSYDRLSD-------APRAPSDRSLSPPWEQERRMTAHPPPGQPYSDPVPQRQDRFYSNSGRL 1236

  Fly  1385 --PRTYRSL------------------SPSDSRYNYNDTETDFSPPPS----------PPPVPSG 1419
              |...||.                  |.:|::.|..::....||.|:          |||.|..
  Rat  1237 SGPAELRSYNMPSLDKVDGPVSSEMESSRNDTKDNLGNSNVPDSPHPTESEAAGRGFIPPPFPPV 1301

  Fly  1420 RS 1421
            |:
  Rat  1302 RA 1303

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tango1	NP_609058.2	SH3	42..113	CDD:302595	18/70 (26%)
		GBP_C	<495..585	CDD:303769	13/96 (14%)
		PKK	496..606	CDD:289257	18/116 (16%)
		coiled coil	560..571	CDD:293879	2/13 (15%)
		Drf_FH1	<1291..1337	CDD:283903	10/45 (22%)
Mia2	NP_001358270.1	SH3	31..103	CDD:388381	22/82 (27%)
		SbcC	<671..>1105	CDD:223496	109/461 (24%)
		PHA03247	<1190..1400	CDD:223021	23/114 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352749
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002364
OrthoInspector	1	1.000	-	-		otm46296
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23158
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	7	6.900