Protein Alignment Tango1 and mia3

DIOPT Version :10

• Sequence 1: NP_609058.2
• Gene: Tango1 / 33930
• FlyBaseID: FBgn0286898
• Length: 1430
• Species: Drosophila melanogaster
• Sequence 2: XP_004914852.2
• Gene: mia3 / 100379945
• XenbaseID: XB-GENE-5897283
• Length: 2853
• Species: Xenopus tropicalis
• Alignment Length: 1706
• Identity: 350/1706 - (20%)
• Similarity: 602/1706 - (35%)
• Gaps: 555/1706 - (32%)

  Fly    74 NSPIRVLSKSAGSNMQLWGVDINGRRGYANKDFIMEK--------------KILVRDKDLLYEVP 124
            |:...|||:   .||        |:.....||.|.||              .:|..||..|
 Frog  1190 NAASAVLSQ---QNM--------GKNNEETKDPINEKVEESSGSPNNLQNSDMLNSDKASL---- 1239

  Fly   125 VVGPGSPVQSVET---------------PVQ-SVETTVQPV-----LNASESTDDLATTTT---- 164
                 :|:|..||               |.| |.:.|||..     |..|..|:|.:..::
 Frog  1240 -----NPIQDTETKEGKETELNMQMPSVPTQESEDGTVQAANQMDPLQESNKTEDSSLPSSDEDV 1299

  Fly   165 -----SPLEIA-----VDSIVVEHDKLQDQQV--------PDPTA---------------ASKAQ 196
                 :..||.     :.::|:....|.|:|:        |:...               |.|.|
 Frog  1300 KEEDETDNEITSYADDIRNLVIIKSYLDDEQINECIKYLGPENIVRVEAMFHDMESELKLARKGQ 1364

  Fly   197 VQVIEGTELPLEAIAATTEGSIVP--ETAADPQEATNLDSTVVDTKEPQALNSE----------A 249
            |:. :..:..|:.|..::|.||:.  |...|.:||:|.:   :|..|....:.|          |
 Frog  1365 VRQ-DYIDKALDEILESSETSILDFVEAVLDEREASNEE---IDASENNMFDGETYLLENIQEIA 1425

  Fly   250 IKLQEEPKAQQPATE-------AEKPPPL-----PQAINAELEDADDFDY-----GDDETDDDSQ 297
            .||:::..|...:|.       .|:..||     |...|.|.|...||..     .::|..|||.
 Frog  1426 YKLRQKHSAYSDSTHLAPGVQAEEQDSPLEEKEPPNERNQEEEKLADFGQPNEKNQEEEKLDDSG 1490

  Fly   298 QGSQDNESIVEIANDNKSINESIELKPLSVAQLKKTDKVEDS-----KDETKEK--------HAE 349
            |.::.|:. .|..:|:...||          :.::.:|::||     |::.:||        ...
 Frog  1491 QPNEKNQE-EEKLDDSGRPNE----------RNQEEEKLDDSGRPNEKNQEEEKLDDSGRPNERN 1544

  Fly   350 MEVSKQEDSSLPTETLNVTALEEQIDQKEFPKQVLDAAVELKSSD-PLPVEEVTETVAEPPRTIV 413
            .|..|.:||..|.|.   ...||::|....|.:......:|..|. |....:..|.:.:..|...
 Frog  1545 QEEEKLDDSGRPNEK---NQEEEKLDDSGRPNEKNQEEEKLDDSGRPNERNQEEEKLDDSGRPKE 1606

  Fly   414 EDKIN-----------EEIVPVSAKIQAKPATVNPTEPIVAQSDAEIKAPSESVISSTTPAPVVE 467
            |:|:|           ||.:..|.:.:.:....:..:|.....|      .|.:..|..|....:
 Frog  1607 EEKLNDSGQQNEKNQKEEKLYDSGQPREEEKLDDSGQPNEKNQD------EEKLDDSGRPTERNQ 1665

  Fly   468 EAPQKADPVGLPPLFEKKNFENPNNYYKQLQEE-------QEKQRL------VAEAEEQKRLQEE 519
            | .:|.|..|.|...||.:.....|...|.:|:       :|:::|      ..:.:|:::|.:.
 Frog  1666 E-EEKLDDSGRPKEEEKLDDSGQPNEKNQEEEKLDDSGQPREEEKLDDSGQPNEKNQEEEKLDDS 1729

  Fly   520 ADQQKRLQEEAALNK--RLLEEAEQQKRLQEEAEQQKRLQEEAELN-------KRLLEEAEKQKR 575
            ....:|.|||..|:.  |..|..:::::|.:..:..:|.|||.:|:       :..|:::.:...
 Frog  1730 GRPTERNQEEEKLDDSGRPTERNQEEEKLDDSGQPTERNQEEEKLDDSGQPREEEKLDDSGRPTE 1794

  Fly   576 LHEESEQL-------QRSSEEAEPQLSVQ--EANMQQLNDSVDSQSNEIVDNNNRQQPEQYQQHH 631
            .::|.|:|       :::.||.:...|.|  |.|.::.|.. ||...|:|...:.:..|:..:..
 Frog  1795 RNQEDEKLDDSGRPNEKNQEEEKLDDSGQPNERNQEEGNLD-DSGRQEVVSEQHIENKEEVLEME 1858

  Fly   632 HHTESAFNHPSTASHTTPTPDAESPYA----AVQEETTEASQTDNHREGVGYVEPVALPATASPV 692
            .||:.....|..:.|...|.:...|.|    :..|||                    :|....|.
 Frog  1859 SHTDKNLEPPFLSDHNVETSETSPPLAHPTDSAPEET--------------------IPNEKEPE 1903

  Fly   693 SEVPIKEDAAGFGLFATIVDTVNNFIGKDPQSDPADSSDELHRILYPGRPEVPPSQRKAEDFAPA 757
            .||..:            |:..:.:...:..:.| ::...|..:|...:..:.|.........|.
 Frog  1904 QEVTAE------------VEVESTYFITEKVTVP-EAIQMLTSLLNATKESLAPLTESLISALPE 1955

  Fly   758 DV----DGYCARFQAKDEHCHRSISLDNFVEVMADKLVDHSQLLLCVVIAAISSLFFMFAYYCFC 818
            |:    |.:..:::|                              .:|.|.:..:..:..::..|
 Frog  1956 DIRPGPDFHGVQWEA------------------------------VIVTAVVGLITILILFWRTC 1990

  Fly   819 NSSQEGALLSKLNHLERSLLASHKENLIIKHDLMTTRTKLASIEDNSFGSNDMVADLKKQLESEL 883
            .|     :.|::..:....||....||:        :.|..::|        .:::.:|::
 Frog  1991 LS-----VKSRVYQVNEKQLAEKIANLV--------KEKSEALE--------KISECEKKI---- 2030

  Fly   884 YEKAKLQEQVGSLERDLDNAAEAGL---------ELNKML-SEVLNGQNGDEAFMSTVDELQRQL 938
             ::||..|.. :|::..|..|||..         :.||.| |::.|..|...:......:.|..:
 Frog  2031 -KEAKESEST-TLKKSTDLLAEAAALKATIKELKDSNKALDSKMRNIMNDLVSQKEQSKKKQEMI 2093

  Fly   939 NDQEKIIIEINNSLAEKSRENSELQYTFTEA---TTRLNSELKTLQEDNYELEMEKSKLQTRLQE 1000
            |:.:|.|.::.:...|.:.|.||||....|.   ..::.:||:.::::|..|:
 Frog  2094 NEGQKSIEKLQDKFLEHTVELSELQAALNEVKLKEAKVRNELRGVKDENSRLK------------ 2146

  Fly  1001 IQAETESELAKALEARNYEMQKLQNQIVELTVKWEREHGDLQTSLA----KIEALEDC---LKAV 1058
               ||:.:|.|..|..:...::|..|| :|.   ::.|.||:.:||    :||.|.:|   ||.:
 Frog  2147 ---ETKEQLLKEAEGWSERQRELDEQI-QLQ---QKSHKDLEETLAYKENEIEVLTNCIMQLKQL 2204

  Fly  1059 GKDAI----HNVQELITSAKTRGELNAVHKKLVELQSK--------------VEQEEAHKQR--- 1102
            ..|:.    .|.|:........||:....|:.:::|.|              :|:|:...||
 Frog  2205 EADSTLVEDGNWQQAGDGELANGEVPEKQKEKMKVQIKQMMDVSRVKTTLSIIEEEKDLYQRKLA 2269

  Fly  1103 --------LESQLQQSSQDVEQLKQDFNQSERDKLEAQTRLEVLSGYFREKENDLKKELSLQETK 1159
                    ||.|:||...|...|:.|..:.:.:....:.::|:|:..:::||..|:|:|:.:|.:
 Frog  2270 DEVSARHDLEEQIQQLQHDGSSLQSDKTRLDNECKTLRQKVEILTELYQQKEMALQKKLTQEEFE 2334

  Fly  1160 WLQHQGENASTVETQTLMKNEIQTLKSQNDELRAEIEAQIASHKAQMGTLENRAHESWLAARQSE 1224
            ....:.:.....|.......|::..|.:..|:..|::....|.|.|:.:.|.:|||:||:||.:|
 Frog  2335 RQDKEQKLTMADEKAVSAVAEVKIYKQRIQEMEEELQKTERSFKNQIASHEKKAHENWLSARSAE 2399

  Fly  1225 RRCEEALAEAASLRRKLTTM-----------------------------------------ASGG 1248
            |...|...|.|:||:||..:                                         .|||
 Frog  2400 RTLAEEKRECANLRQKLIEVNQRVAELQRPAIVKPTPGRPEHQQSLKRGNLSRDGSFGPSPVSGG 2464

  Fly  1249 G----------------------GVGGDPGVMEA-----------------------IAANG--T 1266
            .                      |..||.|.|:.                       :|:.|  |
 Frog  2465 NPSPPLMMDVSGRSSSANLNRSEGPKGDFGAMDIPPGPRCSQADMSGRISAPVELGHLASMGPRT 2529

  Fly  1267 SVLGAELKTAPSP----------------------LP-------LPGSPLLNMPNPLPFLAAPFS 1302
            |.....:...|:|                      ||       .||:|::|.|.....::.|..
 Frog  2530 SSPSMTVDGMPNPPHEPEAPSVAPSFPPPDEAEAVLPGAKGPPSFPGTPVMNSPASAALMSQPPV 2594

  Fly  1303 PFMGLPPPFLPPTGAGGARPPPLGRMRSPPPSSR-----GDRDRERYSDYSDYDDYDDDEEDDRG 1362
            |.|..|   |||.|..|.||   .::..|||..|     |..                 ..|.||
 Frog  2595 PRMIGP---LPPRGPLGPRP---SQLHGPPPGMRPLLPPGPM-----------------PSDPRG 2636

  Fly  1363 MDRRRRHSGSWGRRHRGSY------SHSPRTYRSLSPSDSRYNYNDTETDFSP----------PP 1411
            ..|     |..|.|   .|      ...||.|..|.|.         ..||.|          ||
 Frog  2637 FIR-----GPLGPR---DYPPGPVPPPGPRDYAMLPPG---------VRDFPPGAPIPGPRDFPP 2684

  Fly  1412 SPP--------PVPSG 1419
            .||        |.|.|
 Frog  2685 GPPLARDFPPGPPPPG 2700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tango1	NP_609058.2	SH3	42..113	CDD:473055	12/52 (23%)
		PTZ00121	<191..672	CDD:173412	126/584 (22%)
		Smc	<495..>623	CDD:440809	34/158 (22%)
		SMC_prok_B	854..>1197	CDD:274008	85/391 (22%)
		CwlO1	1078..>1335	CDD:443091	84/398 (21%)
mia3	XP_004914852.2	SH3	33..105	CDD:473055
		PTZ00121	<517..1238	CDD:173412	15/58 (26%)
		SMC_N	1459..2387	CDD:481474	212/1058 (20%)
		PHA03247	<2428..2853	CDD:223021	60/313 (19%)