DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tango1 and CTAGE8

DIOPT Version :9

Sequence 1:	NP_609058.2	Gene:	Tango1 / 33930	FlyBaseID:	FBgn0286898	Length:	1430	Species:	Drosophila melanogaster
Sequence 2:	NP_001265436.1	Gene:	CTAGE8 / 100142659	HGNCID:	37294	Length:	777	Species:	Homo sapiens

Alignment Length:	752	Identity:	169/752 - (22%)
Similarity:	292/752 - (38%)	Gaps:	174/752 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   794 SQLLLC-VVIAAISSLFFMFAYY------CFCNSSQE-GALLS-----KLNHLER-SLLASHKEN 844
            |:|::| .||.....|.|::..:      .:....|: ||.||     |...||: ||:....|.
Human    41 SELVVCAAVIGFFVVLLFLWRSFRSVRSRLYVGREQKLGATLSGLIEEKCKLLEKFSLIQKEYEG 105

  Fly   845 LIIKHDLMTTRTKLASIEDNSFGSNDMVADLKKQLESELYEK-----AKLQEQVGSLERDLDNAA 904
            ..::          :|:||.||  ....|:..:.||:.. ||     ::|::::..||:||....
Human   106 YEVE----------SSLEDASF--EKAAAEEARSLEATC-EKLNRSNSELEDEILCLEKDLKEEK 157

  Fly   905 EAGLELNKMLSEVLNGQNGDEAFMSTVDE---LQRQLND-----------QEKIIIEINNSLAEK 955
            ....:.:::::::      .::..|..||   |:.|:.:           :|:..|.|.::|
Human   158 SKHSQQDELMADI------SKSIQSLEDESKSLKSQIAEAKIICKTFKMSEERRAIAIKDAL--- 213

  Fly   956 SRENSELQYTFTE-----------ATTRLNSELKTLQEDNYELEMEKSKLQTRLQEIQAETE--S 1007
             .|||:||.:..:           ..:.||.:..|.::.....|...:..:..::.:.....  .
Human   214 -NENSQLQTSHKQLFQQEAEVWKGQVSELNKQKITFEDSKVHAEQVLNDKENHIKTLTGHLPMMK 277

  Fly  1008 ELAKALEARNYEMQKLQNQIVELTVKWEREHGDLQTSLAKIEALEDCLKAVGKDAIHNVQELITS 1072
            :.|..||....:...|:   :|:..:||....           |:|.||...|..||..:..::.
Human   278 DQAAVLEEDTTDDDNLE---LEVNSQWENGAN-----------LDDPLKGALKKLIHAAKLNVSL 328

  Fly  1073 AKTRGELNAVHKKLVELQSKVEQEEAHKQRLESQLQQSSQDVEQLKQDFNQSERDKLEAQTRLEV 1137
            ....||.|.:..:|.|:....|:...|.:.|  |.||:|...|.:   :.:||..||  |.:|::
Human   329 KSLEGERNHIIIQLSEVDKTKEELTEHIKNL--QTQQASLQSENI---YFESENQKL--QQKLKI 386

  Fly  1138 LSGYFREKENDLKKELSLQETKWLQHQGENASTVETQTLMKNE-IQTLKSQNDELRAEIEAQIAS 1201
            ::.:::|.|..|.::|:::|...::.: |..|.||.:.....| ::|.:....:|..|:|..:..
Human   387 MTEFYQENEMKLYRKLTVEENYRIEEE-EKLSRVEEKISRATEGLETYRKLAKDLEEELERTVHF 450

  Fly  1202 HKAQMGTLENRAHESWLAARQSERRCEEALAEAASLRRKLTTMASGGGGVGGDPGVMEAIAANGT 1266
            ::.|:.:.|.|.|::|||||.:||...:...|.|..::|||........:..||..::.    ..
Human   451 YQKQVISYEKRGHDNWLAARTAERNLSDLRKENAHNKQKLTETELKFELLEKDPNALDV----SN 511

  Fly  1267 SVLGAE-LKTAPSPLPLPGSPLLNMPNPLPFLAAPFSPFMGLPPPFLPPTGAGGARPPPLGR-MR 1329
            :..|.| ...:||||..|.|.....|:|...|..|..     ..|.||  |.||..|...|. :.
Human   512 TAFGREHSPCSPSPLGRPSSETRAFPSPQTLLEDPLR-----LSPVLP--GGGGRGPSSPGNPLD 569

  Fly  1330 SPPPSSRGDRDRERYSD----YSDYDDYDDDEEDDRGM----------DRR---RRHSGSWGRRH 1377
            ....:.||:...:|..|    .||........|.||.|          |..   :|....:....
Human   570 HQITNERGEPSYDRLIDPHRAPSDTGSLSSPVEQDRRMMFPPPGQSYPDSTLPPQREDRFYSNSE 634

  Fly  1378 RGSYSHSPRTYRSLS--------PSDSRYNYNDTETD---------------------FSP---- 1409
            |.|....||:::..|        ||:...:.||.:.|                     |.|
Human   635 RLSGPAEPRSFKMTSLDKMDRSMPSEMESSRNDAKDDLGNLNVPDSSLPAENEATGPGFIPPPLA 699

  Fly  1410 -------------------PPSPPPVPSGRSATSRPY 1427
                               ||.|||.|......||.|
Human   700 PVRGPLFPVDTRGPFMRRGPPFPPPPPGTMFGASRGY 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tango1	NP_609058.2	SH3	42..113	CDD:302595
		GBP_C	<495..585	CDD:303769
		PKK	496..606	CDD:289257
		coiled coil	560..571	CDD:293879
		Drf_FH1	<1291..1337	CDD:283903	12/46 (26%)
CTAGE8	NP_001265436.1	KASH_CCD	107..298	CDD:291334	38/216 (18%)
		Ax_dynein_light	<157..229	CDD:287215	14/81 (17%)
		SYCE1	338..>445	CDD:291886	29/114 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..673		42/169 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	721..742		7/16 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158741
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002364
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23158
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4780
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.930