Protein Alignment Oatp26F and SLCO2A1

DIOPT Version :10

• Sequence 1: NP_609055.2
• Gene: Oatp26F / 33927
• FlyBaseID: FBgn0051634
• Length: 692
• Species: Drosophila melanogaster
• Sequence 2: NP_005621.2
• Gene: SLCO2A1 / 6578
• HGNCID: 10955
• Length: 643
• Species: Homo sapiens
• Alignment Length: 670
• Identity: 198/670 - (29%)
• Similarity: 325/670 - (48%)
• Gaps: 76/670 - (11%)

  Fly    31 RVGSSISGPDSDAECQRFGWCGWNPAWLQRFCTAKWALFWLCWGGALQ--GLIVNGLINVSISTI 93
            ::|:|   ..||....|.|.|.       |.......:|.|| .|.||  .|:.:.....|::||
Human     6 KLGAS---QGSDTSTSRAGRCA-------RSVFGNIKVFVLC-QGLLQLCQLLYSAYFKSSLTTI 59

  Fly    94 ERRFGLRSRQMGLVASGYDLASFACLVPVTYYGGRRGASKPRFIAIGLIVMGMGSLVFLLPNFLV 158
            |:||||.|...||::|..::::...::.|:|:|.|  ..:||.|.||.:.:..|:.:..||:||.
Human    60 EKRFGLSSSSSGLISSLNEISNAILIIFVSYFGSR--VHRPRLIGIGGLFLAAGAFILTLPHFLS 122

  Fly   159 GNYRATIA--------EANVCETTGLPFNSNSSQSMTACELNAMGEGQSENLTWTVW-LFLAAQL 214
            ..|:.|:|        :|.:|:........:...|.|.       ..|.|  |.::| |.:.|||
Human   123 EPYQYTLASTGNNSRLQAELCQKHWQDLPPSKCHSTTQ-------NPQKE--TSSMWGLMVVAQL 178

  Fly   215 LHGAGASPLFTLGVTYIDENVSKKMSSVYLGIYYTMATVGPAIGYVFGGQLLLIYTDWMTVDPVQ 279
            |.|.|..|:...|::|:|:......|.:|:.|.:.::..|||.||:.|..:|.|:.|:..|:...
Human   179 LAGIGTVPIQPFGISYVDDFSEPSNSPLYISILFAISVFGPAFGYLLGSVMLQIFVDYGRVNTAA 243

  Fly   280 LSLTSDSKVWIGAWWLGFIFAAAMCLLIALPIFGYPKLLP-GAEKL-----QLERVSEAHATISE 338
            ::|......||||||||.:.::|:.:|.:.|.|.:|:.:| ||::.     :..::.||.:..|.
Human   244 VNLVPGDPRWIGAWWLGLLISSALLVLTSFPFFFFPRAMPIGAKRAPATADEARKLEEAKSRGSL 308

  Fly   339 ADDSSNVVRGLPRAVLSLLANPTFFFLNLAGATEGLVIAGFAAFLPKQIENQFSISPMYSALVMG 403
            .|    .::..|...|.||.|..|..:.||..|...||||.:.||.|.:|.|:..|..|:..::|
Human   309 VD----FIKRFPCIFLRLLMNSLFVLVVLAQCTFSSVIAGLSTFLNKFLEKQYGTSAAYANFLIG 369

  Fly   404 LITVPAGGGGTFLGGYLVKKWNLACRGIIKMCLLATTVAALFTI-CFLVSCPNPKFAGV---TTG 464
            .:.:||...|...||.|:|::..:.:.|.::.....|::.:..: .|.:.|..|..|.|   :|.
Human   370 AVNLPAAALGMLFGGILMKRFVFSLQAIPRIATTIITISMILCVPLFFMGCSTPTVAEVYPPSTS 434

  Fly   465 YKMQPSSDSPALVASCNSNCGCSRTNYDPICGVDGVMYYSPCYAGCVQEEHANSLKR---YHNCS 526
            ..:.|  .|||    |..:|.|..:.:.|:||.:|:.|.|||:|||.....:::..:   |.|||
Human   435 SSIHP--QSPA----CRRDCSCPDSIFHPVCGDNGIEYLSPCHAGCSNINMSSATSKQLIYLNCS 493

  Fly   527 CIEQVGFVDDGNPSSEAPHFRPDATNRKCDSTCQ--TLPLFVALCFILMVFTFLATMPALSATLR 589
            |:       .|..:|        |....|...|.  .||....:.|:.:: ..::..|.....||
Human   494 CV-------TGGSAS--------AKTGSCPVPCAHFLLPAIFLISFVSLI-ACISHNPLYMMVLR 542

  Fly   590 CVQDDQRSFALGLQWIKVRLLGTIPAPLIFGALIDESCILWQESCDKDAGGACLVYDNFYI-SRY 653
            .|..:::|||:|:|::.:|||..:|:|.::|..||.|||.|...| ....|||..|||..: .||
Human   543 VVNQEEKSFAIGVQFLLMRLLAWLPSPALYGLTIDHSCIRWNSLC-LGRRGACAYYDNDALRDRY 606

  Fly   654 MWLLALICKLGSVVFFACAW 673
            :.|......||.::....:|
Human   607 LGLQMGYKALGMLLLCFISW 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp26F	NP_609055.2	MFS_SLCO4_OATP4	64..589	CDD:340961	157/550 (29%)
SLCO2A1	NP_005621.2	oat	1..630	CDD:273279	198/670 (30%)