DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Oatp26F and Oatp58Db

DIOPT Version :9

Sequence 1:	NP_609055.2	Gene:	Oatp26F / 33927	FlyBaseID:	FBgn0051634	Length:	692	Species:	Drosophila melanogaster
Sequence 2:	NP_611658.3	Gene:	Oatp58Db / 37544	FlyBaseID:	FBgn0034715	Length:	680	Species:	Drosophila melanogaster

Alignment Length:	707	Identity:	178/707 - (25%)
Similarity:	322/707 - (45%)	Gaps:	74/707 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ATIELDSSIAVAPKCSNVNNNNSARSSRVGSSISGPDSDAECQRFGWCGWNPAWLQRFCTAKWAL 68
            |:.|:::|..:..|.:.:|..:..:  |:.|      ||..|   |:..:....||||.||.  :
  Fly     2 ASEEIEASKFLKDKEAGINVADDEK--RLNS------SDTTC---GFSIFRGPALQRFATAH--M 53

  Fly    69 FWLCWGGALQGLIV-----NGLINVSISTIERRFGLRSRQMGLVASGYDLASFACLVPVTYYGGR 128
            |.:.:|.|...|.:     .|    :|:|:|:||.:.::..||:..|.|:::......::||..|
  Fly    54 FVIVYGIASCFLAMAFTYFTG----TITTMEKRFNIPTKISGLITVGNDISTVFSSAFLSYYASR 114

  Fly   129 RGASKPRFIAIGLIVMGMGSLVFLLPNFLVGNYRATI---AEANVCETTGLPFNSNSSQSMTACE 190
              ..:||::|:|||::.:..|:.|.|:...|.....:   .|..:.|:.|...|..........|
  Fly   115 --GHRPRWVALGLIIIAIFCLLMLTPHIFYGPGEEALRLTEEYGMSESFGASLNITEKNDSLCHE 177

  Fly   191 LNAMGEGQSENLTWTVWLFLAAQLLHGAGASPLFTLGVTYIDENVSKKMSSVYLGIYYTMATVGP 255
            .|:....::.:.| .:.||..||.:.|.|.|..:..|::|:|:|.:...:...|.....:..:||
  Fly   178 KNSNCLERAGDYT-PIVLFFIAQFIGGIGCSLFYAPGLSYMDDNSASSKTPAMLSWSSFLRMLGP 241

  Fly   256 AIGYVFGGQLLLIYTDWMTVDPVQLSL-TSDSKVWIGAWWLGFIFAAAMCLLIALPIFGYPKLLP 319
            |:|:......|.:|     :||.:..| |::...|:||||:|:|....:..:.|:.:..:||.:|
  Fly   242 AMGFSMVSLCLRLY-----IDPFKKPLITTNDPRWMGAWWIGWILLTFILTISAVFVGMFPKEMP 301

  Fly   320 GAEKLQLERVSEAHATISEADDSSNVVRGLPRAVLSLLANPTFFFLNLAGATEGLVIAGFA---A 381
            .|:..:|:...|....:: .....:::..|.|    |.:|..:.:..||..   |.:.|:.   .
  Fly   302 RAKARRLKADGEEDIPLA-GRSFQDMLDSLKR----LASNKVYVYNMLASI---LYLFGYMPYWI 358

  Fly   382 FLPKQIENQFSISPMYSALVMGLITVPAGGGGTFLGGYLVKKWNLACRGIIKMCLLATTVAALFT 446
            |.||.||.|:..|...|.:..|...:.....|..:.||::.|:..:.|.:.....:...:.....
  Fly   359 FTPKYIEIQYRQSASTSTMATGTWALGFSAAGILISGYVISKYKPSARAMAAWNFVVDYLTVAGM 423

  Fly   447 ICF-LVSCPNPKFAGVTTGYKMQPSSDSPALVASCNSNCGCSRTNYDPICGVDGVMYYSPCYAGC 510
            :|: ||.|.....|   ....:.|:.|      ||:::|.|....|.|:|..:.:.:.|.|:|||
  Fly   424 LCYVLVGCDESDRA---NSLSIVPTGD------SCSASCVCEYVYYAPVCSPENITFISACHAGC 479

  Fly   511 VQEEHANSLKR--YHNCSCIEQV-GFVDDGNPSSEAPHFRPDATNRKCDSTC--QTLPLFVALCF 570
            . ::..|.|.:  |..|.|:..| ..:...|.:|.|...: .|.:..|...|  |.|.....:||
  Fly   480 T-DKAINELGKTIYTGCRCMGNVSSIISLSNVTSLASQSQ-IAMDGACPVDCNKQFLIFLAVMCF 542

  Fly   571 ILMVFTFLATMPALSATLRCVQDDQRSFALGLQWIKVRLLGTIPAPLIFGALIDESCILWQESCD 635
            :..|.....:...|.| ||||....::|:||...:...:|..||:|::||.::|..|::|.::|
  Fly   543 LKFVGATGRSSNLLLA-LRCVPSKDKTFSLGFGSMVYSVLAFIPSPIVFGWMLDSYCLVWGKTC- 605

  Fly   636 KDAGGACLVYDNFYISRYMWLLALICKLGSVVFFACAW----WFYVPPSKPLNANGK 688
             .:.|.|.:||...: ||  .:.|:|  .|::|....|    |::....|..:.:.|
  Fly   606 -SSKGNCWIYDTKSL-RY--TMNLVC--ASLIFLGSFWNIGVWYHAKDMKVFDEDEK 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Oatp26F	NP_609055.2	OATP	66..647	CDD:281175	150/598 (25%)
		MFS	69..>318	CDD:119392	66/257 (26%)
		KAZAL_SLC21	476..529	CDD:238650	17/54 (31%)
Oatp58Db	NP_611658.3	OATP	53..619	CDD:281175	151/599 (25%)
		MFS	55..>410	CDD:119392	91/374 (24%)
		KAZAL_SLC21	447..499	CDD:238650	18/58 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446210
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940