Protein Alignment Oatp26F and SLCO4A1

DIOPT Version :10

• Sequence 1: NP_609055.2
• Gene: Oatp26F / 33927
• FlyBaseID: FBgn0051634
• Length: 692
• Species: Drosophila melanogaster
• Sequence 2: XP_011527094.1
• Gene: SLCO4A1 / 28231
• HGNCID: 10953
• Length: 768
• Species: Homo sapiens
• Alignment Length: 672
• Identity: 288/672 - (42%)
• Similarity: 395/672 - (58%)
• Gaps: 53/672 - (7%)

  Fly     2 SEATIELDSSIAVAPKCSNVNNNNSARSSRVGSSISGPDSDAECQRFGWCGWNPAWLQRFCTAKW 66
            |.|...||:|  ..|.|......:.||.:.....:|...|.| |   ||..:.|..||...|.|.
Human    46 SAAHSPLDTS--KQPLCQLWAEKHGARGTHEVRYVSAGQSVA-C---GWWAFAPPCLQVLNTPKG 104

  Fly    67 ALFWLCWGGALQGLIVNGLINVSISTIERRFGLRSRQMGLVASGYDLASFACLVPVTYYGGRRGA 131
            .||:||....|||:.|||.||..|:::|||:.|.|.|.||:||.||:|:..||..|:|:||  ..
Human   105 ILFFLCAAAFLQGMTVNGFINTVITSLERRYDLHSYQSGLIASSYDIAACLCLTFVSYFGG--SG 167

  Fly   132 SKPRFIAIGLIVMGMGSLVFLLPNFLVGNYRATI-AEANVCETTGLPFNSNSSQSMTACELNAMG 195
            .|||::..|:::||.|||||.||:|..|.|...: |....|........::|:..::..:|
Human   168 HKPRWLGWGVLLMGTGSLVFALPHFTAGRYEVELDAGVRTCPANPGAVCADSTSGLSRYQL---- 228

  Fly   196 EGQSENLTWTVWLFLAAQLLHGAGASPLFTLGVTYIDENVSKKMSSVYLGIYYTMATVGPAIGYV 260
                        :|:..|.|||.||:||:||||||:||||....|.||:.|:||.|.:|||.||:
Human   229 ------------VFMLGQFLHGVGATPLYTLGVTYLDENVKSSCSPVYIAIFYTAAILGPAAGYL 281

  Fly   261 FGGQLLLIYTDWMTVDPVQLSLTSDSKVWIGAWWLGFIFAAAMCLLIALPIFGYPKLLPGAEKLQ 325
            .||.||.|||:...    :..||::|.:|:||||:||:.:.|.....|:||.|||:.|||:::..
Human   282 IGGALLNIYTEMGR----RTELTTESPLWVGAWWVGFLGSGAAAFFTAVPILGYPRQLPGSQRYA 342

  Fly   326 LERVSEAH----ATISEAD--DSSNVVRGLPRAVLSLLANPTFFFLNLAGATEGLVIAGFAAFLP 384
            :.|.:|.|    ::..||.  |....:|.||.::..||.||||..|.||||||..:|.|.:.|.|
Human   343 VMRAAEMHQLKDSSRGEASNPDFGKTIRDLPLSIWLLLKNPTFILLCLAGATEATLITGMSTFSP 407

  Fly   385 KQIENQFSISPMYSALVMGLITVPAGGGGTFLGGYLVKKWNLACRGIIKMCLLATTVAALFTICF 449
            |.:|:|||:|...:|.:.|.:.||||||||||||:.|.|..|....:||.||..|.|:.|..:.|
Human   408 KFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFFVNKLRLRGSAVIKFCLFCTVVSLLGILVF 472

  Fly   450 LVSCPNPKFAGVTTGY--KMQPSSDSPALVASCNSNCGCSRTNYDPICGVDGVMYYSPCYAGC-- 510
            .:.||:...||||..|  .:.|.... .|.|.||:.|.|...:|.|:||.||:||:|.|:|||
Human   473 SLHCPSVPMAGVTASYGGSLLPEGHL-NLTAPCNAACSCQPEHYSPVCGSDGLMYFSLCHAGCPA 536

  Fly   511 VQEEHANSLKRYHNCSCIEQVGFVDDGNPSSEAPHFRPDATNRKCDSTCQTLPLFVALCFILMVF 575
            ..|.:.:..|.|.:||||.|       |.||...|    ||..||.||||..||.:...|:::.|
Human   537 ATETNVDGQKVYRDCSCIPQ-------NLSSGFGH----ATAGKCTSTCQRKPLLLVFIFVVIFF 590

  Fly   576 TFLATMPALSATLRCVQDDQRSFALGLQWIKVRLLGTIPAPLIFGALIDESCILWQESCDKDAGG 640
            |||:::|||:||||||:|.|||||||:|||.||:||.||.|:.||.:||::|:|||:.|.:.  |
Human   591 TFLSSIPALTATLRCVRDPQRSFALGIQWIVVRILGGIPGPIAFGWVIDKACLLWQDQCGQQ--G 653

  Fly   641 ACLVYDNFYISRYMWLLALICK 662
            :||||.|..:|||:.::.|:.|
Human   654 SCLVYQNSAMSRYILIMGLLYK 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp26F	NP_609055.2	MFS_SLCO4_OATP4	64..589	CDD:340961	227/535 (42%)
SLCO4A1	XP_011527094.1	MFS_SLCO4A_OATP4A	102..604	CDD:341020	227/535 (42%)