Protein Alignment Oatp26F and SLCO6A1

DIOPT Version :10

• Sequence 1: NP_609055.2
• Gene: Oatp26F / 33927
• FlyBaseID: FBgn0051634
• Length: 692
• Species: Drosophila melanogaster
• Sequence 2: NP_775759.3
• Gene: SLCO6A1 / 133482
• HGNCID: 23613
• Length: 719
• Species: Homo sapiens
• Alignment Length: 687
• Identity: 198/687 - (28%)
• Similarity: 343/687 - (49%)
• Gaps: 71/687 - (10%)

  Fly    17 KCSNVNNNNSARSSRVGSSISGP-------DSDAECQRFGWCGWNPAWLQRFCTAKWALFWLCWG 74
            |.....::.|.:...|..|:..|       .:..||     |.....::..:|     :..:|.|
Human    66 KRKKAKSSVSKKPGEVDDSLEQPCGLGCLVSTCCEC-----CNNIRCFMIFYC-----ILLICQG 120

  Fly    75 GALQGLIVNGLINVSISTIERRFGLRSRQMGLVASGYDLASFACLVPVTYYGGRRGASKPRFIAI 139
                  :|.|||:|||...::.:.|::.:...:...||::|....:.:.:||.|:   |..:...
Human   121 ------VVFGLIDVSIGDFQKEYQLKTIEKLALEKSYDISSGLVAIFIAFYGDRK---KVIWFVA 176

  Fly   140 GLIVMGMGSLVFLLPNFLVGNYRATIAEANVCETTGLPFNSNSSQSMTACELNAMGEGQSENLTW 204
            ...::|:|||:...|:....|.::.:...::||         ..:.::.|:.:.: ..||:.|::
Human   177 SSFLIGLGSLLCAFPSINEENKQSKVGIEDICE---------EIKVVSGCQSSGI-SFQSKYLSF 231

  Fly   205 TVWLFLAAQLLHGAGASPLFTLGVTYIDENVSKKMSSVYLGIYYTMATVGPAIGYVFGGQLLLIY 269
                |:..|.:.|....||:.||:|:|||||:...:.:||||....:.:|.|:|||.|..|:.:.
Human   232 ----FILGQTVQGIAGMPLYILGITFIDENVATHSAGIYLGIAECTSMIGYALGYVLGAPLVKVP 292

  Fly   270 TDWMTVDPVQLSLTSDSKVWIGAWWLGFIFAAAMCLLIALPIFGYPKLLPGAEKLQLERVSEAHA 334
            .:  |......::.:.|..|:..||:.|:|||.:.....:|:..:|..:||:.:::..:..:.|.
Human   293 EN--TTSATNTTVNNGSPEWLWTWWINFLFAAVVAWCTLIPLSCFPNNMPGSTRIKARKRKQLHF 355

  Fly   335 TISEADD---SSNVVRGLPRAVLSLLANPTFFFLNLAGATEGLVIAGFAAFLPKQIENQFSISPM 396
            ..|...|   .:| ::.|..|:..|:.||....|.|:.|||.|||.|.:.|||..:||||.::|.
Human   356 FDSRLKDLKLGTN-IKDLCAALWILMKNPVLICLALSKATEYLVIIGASEFLPIYLENQFILTPT 419

  Fly   397 YSALVMGLITVPAGGGGTFLGGYLVKKWNLACRGIIKMCLLATTVAALFTICFL--VSCPNPKFA 459
            .:..:.||:.:|.|..|..|||.:|....::|:.:::. ::.|:|.:|..:.|:  |.|...:||
Human   420 VATTLAGLVLIPGGALGQLLGGVIVSTLEMSCKALMRF-IMVTSVISLILLVFIIFVRCNPVQFA 483

  Fly   460 GVTTGYKMQPSSDSPALVASCNSNCGCSRTNYDPICGVDGVMYYSPCYAGCVQEEHANSLKRYHN 524
            |:...|  ..:.....|.|.||..|.||.:.|..|||.|.:.|:|||:|||...:..|..|.|:|
Human   484 GINEDY--DGTGKLGNLTAPCNEKCRCSSSIYSSICGRDDIEYFSPCFAGCTYSKAQNQKKMYYN 546

  Fly   525 CSCIEQVGFVDDGNPSSEAPHFRPDATNRKCDSTCQTLPLFVALCFILMVFTFLATMPALSATLR 589
            ||||:      :|..:::|.....||...|||:.|..||||:|..|..::|:..:.:|.:.|..|
Human   547 CSCIK------EGLITADAEGDFIDARPGKCDAKCYKLPLFIAFIFSTLIFSGFSGVPIVLAMTR 605

  Fly   590 CVQDDQRSFALGLQWIKVRLLGTIPAPLIFGALIDESCILWQESCDKDAG-----GACLVYDNFY 649
            .|.|..||.|||:.::.:|:.||||.|.||....:.||||      :|..     |.|.:|:...
Human   606 VVPDKLRSLALGVSYVILRIFGTIPGPSIFKMSGETSCIL------RDVNKCGHTGRCWIYNKTK 664

  Fly   650 ISRYMWLLALICKLGSVVFFACAWWFYVPPSKPLNAN 686
            ::..:..:..:|||.:::|...|::.|   .:.||.|
Human   665 MAFLLVGICFLCKLCTIIFTTIAFFIY---KRRLNEN 698

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp26F	NP_609055.2	MFS_SLCO4_OATP4	64..589	CDD:340961	156/529 (29%)
SLCO6A1	NP_775759.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..46
		MFS_SLCO6_OATP6	105..605	CDD:340963	157/539 (29%)