Protein Alignment Oatp26F and SLCO1B1

DIOPT Version :10

• Sequence 1: NP_609055.2
• Gene: Oatp26F / 33927
• FlyBaseID: FBgn0051634
• Length: 692
• Species: Drosophila melanogaster
• Sequence 2: NP_006437.3
• Gene: SLCO1B1 / 10599
• HGNCID: 10959
• Length: 691
• Species: Homo sapiens
• Alignment Length: 622
• Identity: 185/622 - (29%)
• Similarity: 311/622 - (50%)
• Gaps: 65/622 - (10%)

  Fly    85 LINVSISTIERRFGLRSRQMGLVASGYDLASFACLVPVTYYGGRRGASKPRFIAIGLIVMGMGSL 149
            ::..||..|||||.:.|..:|.:...:::.:...:|.|:|:|.:  ..:|:.|.||..:||:|.:
Human    47 IMKSSIIHIERRFEISSSLVGFIDGSFEIGNLLVIVFVSYFGSK--LHRPKLIGIGCFIMGIGGV 109

  Fly   150 VFLLPNFLVGNYRATIAEANVCETTGLPFNSNSSQSMTACELN-----------AMGEG---QSE 200
            :..||:|.:|.||.:       :.|.:..:.||:.:::.|.:|           .:|:|   :|.
Human   110 LTALPHFFMGYYRYS-------KETNINSSENSTSTLSTCLINQILSLNRASPEIVGKGCLKESG 167

  Fly   201 NLTWTVWLFLAAQLLHGAGASPLFTLGVTYIDENVSKKMSSVYLGIYYTMATVGPAIGYVFGGQL 265
            :..| :::|: ..:|.|.|.:|:..||::|||:...:..||:||||...:|.:||.||:..|...
Human   168 SYMW-IYVFM-GNMLRGIGETPIVPLGLSYIDDFAKEGHSSLYLGILNAIAMIGPIIGFTLGSLF 230

  Fly   266 LLIYTDWMTVDPVQLSLTSDSKVWIGAWWLGFIFAAAMCLLIALPIFGYPKLLPGAEKLQLERVS 330
            ..:|.|...||...:.:|.....|:|||||.|:.:....::.::|.|..|:.   ..|.|.||.:
Human   231 SKMYVDIGYVDLSTIRITPTDSRWVGAWWLNFLVSGLFSIISSIPFFFLPQT---PNKPQKERKA 292

  Fly   331 --EAHA--TISEADDSSNV----------VRGLPRAVLSLLANPTFFFLNLAGATEGLVIAGFAA 381
              ..|.  |..|.|.::|:          |.|..::..|:|.||.:....|....:.....|...
Human   293 SLSLHVLETNDEKDQTANLTNQGKNITKNVTGFFQSFKSILTNPLYVMFVLLTLLQVSSYIGAFT 357

  Fly   382 FLPKQIENQFSISPMYSALVMGLITVPAGGGGTFLGGYLVKKWNLACRGIIKM-CLLATTVAALF 445
            ::.|.:|.|:......:.:::|:||:|....|.|||||::||:.|...||.|. |..|....:.:
Human   358 YVFKYVEQQYGQPSSKANILLGVITIPIFASGMFLGGYIIKKFKLNTVGIAKFSCFTAVMSLSFY 422

  Fly   446 TICFLVSCPNPKFAGVTTGY----KMQPSSDSPALVASCNSNCGCSRTNYDPICGVDGVMYYSPC 506
            .:.|.:.|.|...||:|..|    .:....|.|  ::.|||:|.|..:.::|:||.:|:.|.|||
Human   423 LLYFFILCENKSVAGLTMTYDGNNPVTSHRDVP--LSYCNSDCNCDESQWEPVCGNNGITYISPC 485

  Fly   507 YAGCVQEEHANSLKRYHNCSCIEQVGFVDDGNPSS---EAPHFRPDATNRKCDSTCQTLPLFVAL 568
            .|||...........::||||:|..| :.:.|.|:   |.|  |.||..||       ...|||:
Human   486 LAGCKSSSGNKKPIVFYNCSCLEVTG-LQNRNYSAHLGECP--RDDACTRK-------FYFFVAI 540

  Fly   569 CFILMVFTFLATMPALSATLRCVQDDQRSFALGLQWIKVRLLGTIPAPLIFGALIDESCILWQ-E 632
            ..:.:.|:.|.....:...::.||.:.:|.|||...:.:|.||.|.||:.||||||.:||.|. .
Human   541 QVLNLFFSALGGTSHVMLIVKIVQPELKSLALGFHSMVIRALGGILAPIYFGALIDTTCIKWSTN 605

  Fly   633 SCDKDAGGACLVYDNFYISRYMWLLALICKLGSVVFF 669
            :|  ...|:|..|::...||....|:.:.::.|:|.:
Human   606 NC--GTRGSCRTYNSTSFSRVYLGLSSMLRVSSLVLY 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp26F	NP_609055.2	MFS_SLCO4_OATP4	64..589	CDD:340961	155/539 (29%)
SLCO1B1	NP_006437.3	MFS	27..561	CDD:475125	155/539 (29%)