Protein Alignment Oatp26F and Slco2b1

DIOPT Version :10

• Sequence 1: NP_609055.2
• Gene: Oatp26F / 33927
• FlyBaseID: FBgn0051634
• Length: 692
• Species: Drosophila melanogaster
• Sequence 2: XP_011239939.1
• Gene: Slco2b1 / 101488
• MGIID: 1351872
• Length: 697
• Species: Mus musculus
• Alignment Length: 674
• Identity: 196/674 - (29%)
• Similarity: 329/674 - (48%)
• Gaps: 78/674 - (11%)

  Fly    35 SISGPDSDAECQRFGWCGWNPAWLQRFCTAKWALFWLCWG-GALQGLIVNGLINVSISTIERRFG 98
            |:...||..:.|..|          .|...|:  |.||.. ..|..|:::|.:..||||:|:|||
Mouse    35 SVEPQDSHQDAQPRG----------MFHNIKF--FVLCHSLLQLTQLMISGYLKSSISTVEKRFG 87

  Fly    99 LRSRQMGLVASGYDLASFACLVPVTYYGGRRGASKPRFIAIGLIVMGMGSLVFLLPNFLVGNYRA 163
            |.|:..||:|:..::.:.:.::.|:|:|.|  ..:||.|..|.:::....|:..||:|:...||
Mouse    88 LSSQISGLLAAFNEVGNVSLILFVSYFGSR--VHRPRMIGYGALLVATAGLLMALPHFISEPYR- 149

  Fly   164 TIAEANVCETTGLPFNSNSSQSMTACELNAMGEGQSENLTWT-----VWLFLAAQLLHGAGASPL 223
              .:.:..:...|.|.::.....|....:|:..|...:.|.|     |.:..|||.|.|.|..|:
Mouse   150 --YDHSSSDNRSLDFEASLCLPTTMAPASALSNGSCSSHTETKHLTMVGIMFAAQTLLGIGGVPI 212

  Fly   224 FTLGVTYIDENVSKKMSSVYLGIYYTMATVGPAIGYVFGGQLLLIYTDWMTVDPVQLSLTSDSKV 288
            ...|::|||:......|.:|:||.:.:.|:||.:.|..|..:|.:|.|...:....::||.....
Mouse   213 QPFGISYIDDFAHHSNSPLYIGILFGITTMGPGLAYGLGSLMLRLYVDIDRMPEGGINLTPKDPR 277

  Fly   289 WIGAWWLGFIFAAAMCLLIALPIFGYPKLLPGAEK----LQLERVSEAHATISEADDSSN----- 344
            |:|||||||:.::.:.:|.:.|.|.:|:.:| .||    .:.:.::.|.:|.|:.:|.|:
Mouse   278 WVGAWWLGFLISSGLVVLASSPYFFFPREMP-KEKHEFHFRRKVLASAASTASKGEDLSSQHEPL 341

  Fly   345 -----------------VVRGLPRAVLSLLANPTFFFLNLAGATEGLVIAGFAAFLPKQIENQFS 392
                             .|:..||.:|..|.:|.|..:.|:......::||.|.||||.:|.|||
Mouse   342 KKQAGLAQIAPDLTLVQFVKVFPRVLLRNLRHPIFLLVVLSQVCTSSMVAGMATFLPKFLERQFS 406

  Fly   393 ISPMYSALVMGLITVPAGGGGTFLGGYLVKKWNLACRGIIKMCLLATTVAALFTI-CFLVSCPNP 456
            |:..::.:::|.:|:|....|..:||.|||:.:|:......:|||.:.:..||:: .|.:.|...
Mouse   407 ITASFANMLLGCLTIPLVIVGIMMGGVLVKRLHLSPVQCSALCLLGSLLCLLFSVPLFFIGCSTH 471

  Fly   457 KFAGVTTGYKMQPSSDSPALVASCNSNCGCSRTNYDPICGVDG-VMYYSPCYAGC----VQEEHA 516
            :.||:|.....||   .|:|...|:..|.|...:::|:|.... |.|.:||:|||    |||...
Mouse   472 QIAGITQDLGAQP---GPSLFPGCSEPCSCQSDDFNPVCDTSAYVEYTTPCHAGCTGRVVQEALG 533

  Fly   517 NSLKRYHNCSCIEQVGFVDDGNPSSEAPHFRPDATNRKCDSTCQTLPL-FVALCFILMVFTFLAT 580
            .|...|.||||:...|.|..|:                |:|.|..|.| |:.|..:......:..
Mouse   534 KSQVFYTNCSCVAGNGTVPAGS----------------CESACSRLVLPFIVLFSLGAGLASITH 582

  Fly   581 MPALSATLRCVQDDQRSFALGLQWIKVRLLGTIPAPLIFGALIDESCILWQESCDKDAGGACLVY 645
            .|:....||.|:.:.::.|:|:|::.:|:|..:|:|:|.|:.||.:|:.|..:|.:.|  .|..|
Mouse   583 TPSFMLILRGVKKEDKTLAVGMQFMLLRVLAWMPSPVIHGSAIDTTCVHWALTCGRRA--VCRYY 645

  Fly   646 DNFYISRYMWLLALICKLGSVVFF 669
            |:..:......|....|.||:|.|
Mouse   646 DHDLLRNRFIGLQFFFKSGSLVCF 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Oatp26F	NP_609055.2	MFS_SLCO4_OATP4	64..589	CDD:340961	163/563 (29%)
Slco2b1	XP_011239939.1	MFS	54..591	CDD:475125	163/563 (29%)