DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-iota and FCRLA

DIOPT Version :9

Sequence 1:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001171795.2	Gene:	FCRLA / 84824	HGNCID:	18504	Length:	365	Species:	Homo sapiens

Alignment Length:	277	Identity:	58/277 - (20%)
Similarity:	93/277 - (33%)	Gaps:	70/277 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 LLTCVVHDLVSFKVAWLRVDTQTILSIQNHVITKNHRISISHTEHRIWQLKIRDVQESDRGWYMC 113
            ||....|...||:.          |..:..|.|:.   |..|||.        |:.::....:..
Human    25 LLAAGCHAAASFET----------LQCEGPVCTEE---SSCHTED--------DLTDAREAGFQV 68

  Fly   114 QINT--DPMKSQMGYLDVVVPPDIVDYQTSQDVVRST--GQNVTLTCSA-TGVPMPTITWRREEA 173
            :..|  :|....:.|          |:...|...:..  |..:.|.|.| ...|:..:|:.|:.:
Human    69 KAYTFSEPFHLIVSY----------DWLILQGPAKPVFEGDLLVLRCQAWQDWPLTQVTFYRDGS 123

  Fly   174 TPILISDDGDREVFSVEGQNLTLWQVQRSHMGAYLCIA-----SNGVPPTVSKRVMLVVNFAPT- 232
            .   :...|....||:.       .||::..|.|.|..     ..|:|.|.|...:.|....|.
Human   124 A---LGPPGPNREFSIT-------VVQKADSGHYHCSGIFQSPGPGIPETASVVAITVQELFPAP 178

  Fly   233 IWTRYDTIYVGLGQKLTLECIT----ESQPASVNF-WLRDSQLLQGGSYESVSVDHVFRIVMRIT 292
            |.....:.....|..:||.|.|    :...|.:.| :.:|.:::|     |..:...|:|
Human   179 ILRAVPSAEPQAGSPMTLSCQTKLPLQRSAARLLFSFYKDGRIVQ-----SRGLSSEFQI----- 233

  Fly   293 LRPITKRDF-GEYICRA 308
              |....|. |.|.|.|
Human   234 --PTASEDHSGSYWCEA 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	15/77 (19%)
		Ig	39..122	CDD:299845	15/74 (20%)
		Ig	132..213	CDD:299845	17/88 (19%)
		IG_like	141..227	CDD:214653	20/93 (22%)
		IG_like	239..322	CDD:214653	18/76 (24%)
		IGc2	245..313	CDD:197706	18/70 (26%)
FCRLA	NP_001171795.2	Ig	85..152	CDD:353325	16/76 (21%)
		Ig_2	177..266	CDD:316418	19/84 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	265..319
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000