DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-iota and KIRREL3

DIOPT Version :9

Sequence 1:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	XP_011541328.1	Gene:	KIRREL3 / 84623	HGNCID:	23204	Length:	809	Species:	Homo sapiens

Alignment Length:	357	Identity:	77/357 - (21%)
Similarity:	149/357 - (41%)	Gaps:	55/357 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 NSTVPVGRDALLTCVVHDLVSFKVAWLRVDTQTILSIQNHVIT--KNHRISISHTEHRIWQLKIR 101
            |..:|.|::   |.|..|:....:..|.|:.|.:|  :::|:|  .:.:.:.:.|::| |..:.:
Human   237 NKAIPGGKE---TSVTIDIQHPPLVNLSVEPQPVL--EDNVVTFHCSAKANPAVTQYR-WAKRGQ 295

  Fly   102 DVQESDRGWYMCQIN----TDPMKSQM----------GYLDVVVPPDIVDYQTSQDVVRSTGQNV 152
            .::|:....|...::    ::|:..::          ..:||...|.:.  ...|.::...|.:.
Human   296 IIKEASGEVYRTTVDYTYFSEPVSCEVTNALGSTNLSRTVDVYFGPRMT--TEPQSLLVDLGSDA 358

  Fly   153 TLTCSATGVPMPTITWRREEATPILISDDGDREVFSVEGQNLTLWQVQRSHMGAYLCIASNGVPP 217
            ..:|:.||.|..||.|.:..:..:|.::           :.|||..|::...|.|:|.|   |.|
Human   359 IFSCAWTGNPSLTIVWMKRGSGVVLSNE-----------KTLTLKSVRQEDAGKYVCRA---VVP 409

  Fly   218 TV---SKRVMLVVNFAPTIWTRYDTIYVGLGQKLTLECITESQPASVNF-WLRDSQLLQGG---- 274
            .|   .:.|.|.|| .|.|.:...|.:...|:|..::|...|.|..... |.....:|:.|
Human   410 RVGAGEREVTLTVN-GPPIISSTQTQHALHGEKGQIKCFIRSTPPPDRIAWSWKENVLESGTSGR 473

  Fly   275 -SYESVSVDHVFRIVMRITLRPITKRDFGE-YICRAKNAMGQTDRIITVHHKAKKHGQHSHQTSS 337
             :.|::|.:.  .::..:|:..|.:.||.. |.|.|.|:.|....||    :.|:.|......:.
Human   474 YTVETISTEE--GVISTLTISNIVRADFQTIYNCTAWNSFGSDTEII----RLKEQGSEMKSGAG 532

  Fly   338 RESQFIVIEEYIANMSDKSCSFQPLWIMFLCF 369
            .|::.:.:...|........:|..|....:.|
Human   533 LEAESVPMAVIIGVAVGAGVAFLVLMATIVAF 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	18/101 (18%)
		Ig	39..122	CDD:299845	18/88 (20%)
		Ig	132..213	CDD:299845	19/80 (24%)
		IG_like	141..227	CDD:214653	23/88 (26%)
		IG_like	239..322	CDD:214653	22/89 (25%)
		IGc2	245..313	CDD:197706	18/74 (24%)
KIRREL3	XP_011541328.1	Ig	58..149	CDD:299845
		IG_like	60..149	CDD:214653
		I-set	156..249	CDD:254352	4/14 (29%)
		Ig2_KIRREL3-like	171..252	CDD:143236	5/17 (29%)
		Ig_2	260..337	CDD:290606	12/79 (15%)
		I-set	341..422	CDD:254352	24/96 (25%)
		IGc2	355..406	CDD:197706	16/61 (26%)
		Ig5_KIRREL3	424..521	CDD:143306	24/102 (24%)
		IG_like	432..521	CDD:214653	22/94 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810