DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-iota and robo4

DIOPT Version :9

Sequence 1:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	XP_689255.3	Gene:	robo4 / 560765	ZFINID:	ZDB-GENE-020809-1	Length:	1134	Species:	Danio rerio

Alignment Length:	376	Identity:	87/376 - (23%)
Similarity:	137/376 - (36%)	Gaps:	88/376 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SELNNSDPKFSGPINNSTVPVGRDALLTCVVHDLVSFKVAWLR---------VDTQT-------- 71
            ||:|.  |:.....::..|.||..|.|:|.........:.|||         :|.|:
Zfish    66 SEINL--PRIVHHPSDVVVRVGSPATLSCRAEGNPEPTIQWLRNGQPLDTDKMDAQSQPIVLPDG 128

  Fly    72 ---ILSI------QNH-----VITKNHRISISHTEHRIWQLKIRDVQESDRGWYMCQINTDPMKS 122
               ..|:      |:|     .|..|   ||.:...|...|.|..::|
Zfish   129 SLFFFSVVPGRKGQSHEAVYACIAHN---SIGNATSRNASLHIAALRE----------------- 173

  Fly   123 QMGYLDVVVPPDIVDYQTSQDVVRSTGQNVTLTCS-ATGVPMPTITWRREEATPILISDDGDREV 186
                 |..|.|        .||..:.|:..|:.|| ..|.|.|.:|||::   .|||:...:...
Zfish   174 -----DFRVQP--------SDVEVAIGEMATINCSPPVGHPEPNVTWRKD---GILINSSNEHYT 222

  Fly   187 FSVEGQNLTLWQVQRSHMGAYLCIASNGVPPTVSKRVMLVVNFAPTIWTRYDTIYVGLGQKLTLE 251
             .::|: |.:...|::..|.|.|||||.:....|:...|.|...|.:..:.:.:.|.||:.....
Zfish   223 -ELKGK-LIIAPAQKNDSGVYSCIASNMIGVRESRAARLSVLAKPVLLRKPEDVSVQLGESAQFF 285

  Fly   252 CITESQPASVNFWLRDSQLLQGGSYESVSVDHVFRIVMRITLRPITKRDFGEYICRAKNAMG--- 313
            |..:..|.....|.|:...|..|.| .::.||..:|      ..:|.:|.|.|.|..:|.:|
Zfish   286 CEADGDPMPSIEWSREQGPLPNGRY-LINPDHSLQI------HYVTAQDMGRYSCTVENKLGVSV 343

  Fly   314 -QTDRIITVHHKAKKHGQHSHQTSSRESQFIVIEEYIANMSDKSCSFQPLW 363
             ....::......:....|...::.|.|.     |.:..||..|...|.:|
Zfish   344 ASAQLLVEDAGGTRLRDLHKELSALRVSL-----ENVTVMSTASNMSQVMW 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	22/116 (19%)
		Ig	39..122	CDD:299845	22/113 (19%)
		Ig	132..213	CDD:299845	24/81 (30%)
		IG_like	141..227	CDD:214653	27/86 (31%)
		IG_like	239..322	CDD:214653	20/86 (23%)
		IGc2	245..313	CDD:197706	17/67 (25%)
robo4	XP_689255.3	Ig1_Robo	70..169	CDD:143317	21/103 (20%)
		I-set	71..168	CDD:254352	21/99 (21%)
		I-set	175..261	CDD:254352	29/98 (30%)
		Ig2_Robo	177..261	CDD:143201	29/96 (30%)
		I-set	265..350	CDD:254352	21/91 (23%)
		Ig	282..350	CDD:299845	17/74 (23%)
		FN3	373..448	CDD:214495	6/17 (35%)
		FN3	472..560	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900