DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-iota and lrit3a

DIOPT Version :9

Sequence 1:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001122166.1	Gene:	lrit3a / 558559	ZFINID:	ZDB-GENE-080723-63	Length:	636	Species:	Danio rerio

Alignment Length:	358	Identity:	67/358 - (18%)
Similarity:	122/358 - (34%)	Gaps:	125/358 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RRLPSFWLLLLQSVCFSQASFSELNNSDPKFSGPINNSTVPVGRDALLTCVVHDLVSFKVAWLRV 67
            ||:|:.....|..:.:...:::.:.:.||   |...|..           |:|:        ||:
Zfish    70 RRVPTEAFYYLSELRYLWITYNSITSVDP---GSFYNLK-----------VLHE--------LRL 112

  Fly    68 DTQTILSIQNHVITKNHRISISHTEHRIWQ-------LKIRDVQESDRGWYMCQINTDPMKS--- 122
            |...|.:..                   |:       ||..|:..:       ::.:.|:::
Zfish   113 DGNMIATFP-------------------WESLKEMPSLKTLDLHNN-------RLTSVPVEAAPY 151

  Fly   123 --QMGYLDV------VVPPDIVDY-----------QTSQDVVRSTGQNV-TLTCSATGVPMPTIT 167
              .:.|||:      .:|.|:||.           .|||..|.....|. ...|..:.:    |.
Zfish   152 LINITYLDISSNKLTTLPSDLVDIWPPFSGIQPSANTSQKTVLGLQDNPWYCDCRISKL----IE 212

  Fly   168 WRREEATPILISDDGDREVFSVEG-QNLTLWQVQRSHMGAYLCIASNGVPPTVSKRVMLVVNFAP 231
            ..:....|:::.|    :|.:..| ::|:....||:.:..  |:                   .|
Zfish   213 LSKMAGIPVVLMD----QVLTCSGPEHLSGVLFQRAELDQ--CV-------------------KP 252

  Fly   232 TIWTRYDTIYVGLGQKLTLECITESQPASVNFW------LRDSQLLQGGSYESV--SVDHVFRIV 288
            |:.|....|...||..:.|.|.....|.....|      :.::.::|....|.|  |:
Zfish   253 TVMTSATKITSPLGSNVLLRCDANGFPTPTLLWTTADGSVVNNTVVQESPGEGVRWSI------- 310

  Fly   289 MRITLRPITKRDFGEYICRAKNAMGQTDRIITV 321
              ::|..|..:|.|:|.|:|||..|..:..||:
Zfish   311 --LSLHSIVFKDAGDYRCKAKNVAGNAEAYITL 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	12/97 (12%)
		Ig	39..122	CDD:299845	12/89 (13%)
		Ig	132..213	CDD:299845	19/93 (20%)
		IG_like	141..227	CDD:214653	14/87 (16%)
		IG_like	239..322	CDD:214653	23/91 (25%)
		IGc2	245..313	CDD:197706	18/75 (24%)
lrit3a	NP_001122166.1	LRR_8	81..141	CDD:290566	14/107 (13%)
		leucine-rich repeat	83..106	CDD:275378	4/36 (11%)
		LRR_4	107..145	CDD:289563	9/71 (13%)
		leucine-rich repeat	107..130	CDD:275378	6/49 (12%)
		LRR_8	129..>171	CDD:290566	8/48 (17%)
		LRR_4	129..170	CDD:289563	7/47 (15%)
		leucine-rich repeat	131..154	CDD:275378	4/29 (14%)
		leucine-rich repeat	155..168	CDD:275378	3/12 (25%)
		TPKR_C2	199..249	CDD:301599	10/59 (17%)
		Ig	252..343	CDD:299845	26/99 (26%)
		IG_like	261..343	CDD:214653	23/90 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900