DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-iota and KIRREL1

DIOPT Version :9

Sequence 1:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	XP_005245362.1	Gene:	KIRREL1 / 55243	HGNCID:	15734	Length:	773	Species:	Homo sapiens

Alignment Length:	337	Identity:	79/337 - (23%)
Similarity:	137/337 - (40%)	Gaps:	61/337 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 WLLLLQSVCFSQASFSELNNSDPKFSGPINNSTVPVGRDALLTCVVHDLVSFK--VAWLRVDTQT 71
            |:|.| |..|||       .:..:||....:.||..|:.|:|.||   |:::.  |.|.: |...
Human     7 WILTL-SDTFSQ-------GTQTRFSQEPADQTVVAGQRAVLPCV---LLNYSGIVQWTK-DGLA 59

  Fly    72 ILSIQNHVITKNHRISISHTEHRIWQLKIRDVQESDRGWYMCQINTDPMKSQMGYLDVVVPPDIV 136
            :...|.......:|: :...:...:.|:|.|.:.||...|.||.....::|:...|.|::||:..
Human    60 LGMGQGLKAWPRYRV-VGSADAGQYNLEITDAELSDDASYECQATEAALRSRRAKLTVLIPPEDT 123

  Fly   137 DYQTSQDVVRSTGQNVTLTCSA-TGVPMPTITWRRE--------EATPILISDDGDREV----FS 188
            .......::...|....|||.| ...|..||.|.|:        .:|.:|  .||.||.    ..
Human   124 RIDGGPVILLQAGTPHNLTCRAFNAKPAATIIWFRDGTQQEGAVASTELL--KDGKRETTVSQLL 186

  Fly   189 VEGQNLTLWQVQRSHMGAYLCIASN-GVPPTVSKRVMLVVNFAPTIWTRYDTIYVGLGQKLTLEC 252
            :...:|.:.:|       :.|.:.| .:|......:.|.|:..||:....:...|..|:::...|
Human   187 INPTDLDIGRV-------FTCRSMNEAIPSGKETSIELDVHHPPTVTLSIEPQTVQEGERVVFTC 244

  Fly   253 ITESQPASVNF-WLRDSQLLQGGSYES---VSVDHVFRIVMRITLRPITKRDFGEYI-CRAKNAM 312
            ...:.|..:.: |.:...|:: .::||   .:||:.|               |.|.: |...|.:
Human   245 QATANPEILGYRWAKGGFLIE-DAHESRYETNVDYSF---------------FTEPVSCEVHNKV 293

  Fly   313 GQTD--RIITVH 322
            |.|:  .::.||
Human   294 GSTNVSTLVNVH 305

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	22/87 (25%)
		Ig	39..122	CDD:299845	21/84 (25%)
		Ig	132..213	CDD:299845	21/93 (23%)
		IG_like	141..227	CDD:214653	22/99 (22%)
		IG_like	239..322	CDD:214653	17/89 (19%)
		IGc2	245..313	CDD:197706	14/72 (19%)
KIRREL1	XP_005245362.1	I-set	22..116	CDD:254352	25/98 (26%)
		Ig	25..116	CDD:299845	23/95 (24%)
		Ig2_KIRREL3-like	138..219	CDD:143236	21/89 (24%)
		I-set	223..304	CDD:254352	19/96 (20%)
		Ig_2	227..305	CDD:290606	17/93 (18%)
		Ig_2	311..405	CDD:290606
		IG_like	314..405	CDD:214653
		Ig5_KIRREL3	407..504	CDD:143306
		IG_like	416..504	CDD:214653
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810