DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment DIP-iota and SDK2

DIOPT Version :9

Sequence 1:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_001138424.1	Gene:	SDK2 / 54549	HGNCID:	19308	Length:	2172	Species:	Homo sapiens

Alignment Length:	399	Identity:	90/399 - (22%)
Similarity:	140/399 - (35%)	Gaps:	116/399 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GRRLP---------SFWLLLLQSVC------FSQASFSELNNSDPKFSGPI-------------- 37
            ||::|         ...|::|.:|.      :.||...:  |.|.|.|.||
Human   151 GRKIPPSSRIAITLENTLVILSTVAPDAGRYYVQAVNDK--NGDNKTSQPITLTVENVGGPADPI 213

  Fly    38 ---------NNSTVPVGRDALLTCVVH--DLVSFKVAWLRVDTQTILSIQNHVITKNHRISISHT 91
                     |.|.|....:..|.||.:  .|:...:.|.:........|.:|    |.|::|.:.
Human   214 APTIIIPPKNTSVVAGTSEVTLECVANARPLIKLHIIWKKDGVLLSGGISDH----NRRLTIPNP 274

  Fly    92 EHRIWQLKIRDVQESDRGWYMCQI----NTDPMKSQMGYLDVVVPPDIVDYQTSQDVVRSTGQNV 152
                        ..||.|:|.|:.    ::.|...:..||.|:.||..|. :..:.:.....:.|
Human   275 ------------TGSDAGYYECEAVLRSSSVPSVVRGAYLSVLEPPQFVK-EPERHITAEMEKVV 326

  Fly   153 TLTCSATGVPMPTITWRREEATPILISDDGDREVFSVEGQNLTLWQVQRS------------HMG 205
            .:.|.|.|||.|:|||.::.|.              ||.:.||.:: ||:            ..|
Human   327 DIPCQAKGVPPPSITWYKDAAV--------------VEVEKLTRFR-QRNDGGLQISGLVPDDTG 376

  Fly   206 AYLCIASNGVPPTVSKRVMLVVNFAPTIWTR--YDTIYVGLGQKLTLECITESQPASVNFWLRDS 268
            .:.|.|.|......:...:.|.:.||.| ||  .|:..:. |..:.|.|.|...|.....|.:..
Human   377 MFQCFARNAAGEVQTSTYLAVTSIAPNI-TRGPLDSTVID-GMSVVLACETSGAPRPAITWQKGE 439

  Fly   269 QLLQGGS--------YESVSVDHVFRIVMRITLRPITKRDFGEYICRAKNAMG----QTDRIITV 321
            ::|..||        .||.|          :.:.|....|.|.|.|.|.|:.|    ..|.::..
Human   440 RILASGSVQLPRFTPLESGS----------LLISPTHISDAGTYTCLATNSRGVDEASADLVVWA 494

  Fly   322 HHKAKKHGQ 330
            ..:..|..|
Human   495 RTRITKPPQ 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	18/91 (20%)
		Ig	39..122	CDD:299845	18/88 (20%)
		Ig	132..213	CDD:299845	23/92 (25%)
		IG_like	141..227	CDD:214653	21/97 (22%)
		IG_like	239..322	CDD:214653	21/94 (22%)
		IGc2	245..313	CDD:197706	19/75 (25%)
SDK2	NP_001138424.1	Ig	27..109	CDD:299845
		IG_like	40..109	CDD:214653
		I-set	120..203	CDD:254352	14/53 (26%)
		Ig	132..210	CDD:299845	14/60 (23%)
		IG_like	222..304	CDD:214653	21/97 (22%)
		IGc2	233..286	CDD:197706	15/68 (22%)
		I-set	308..397	CDD:254352	23/104 (22%)
		Ig	326..394	CDD:143165	21/82 (26%)
		I-set	402..492	CDD:254352	26/101 (26%)
		Ig	416..492	CDD:299845	21/85 (25%)
		Ig	502..586	CDD:299845	1/2 (50%)
		IG_like	502..586	CDD:214653	1/2 (50%)
		FN3	590..681	CDD:238020
		FN3	693..786	CDD:238020
		FN3	794..890	CDD:238020
		FN3	895..983	CDD:238020
		FN3	993..1087	CDD:238020
		FN3	1099..1194	CDD:238020
		FN3	1201..1290	CDD:238020
		FN3	1301..1394	CDD:238020
		FN3	1400..1484	CDD:238020
		FN3	1503..1616	CDD:238020
		FN3	1626..1719	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1707..1729
		FN3	1724..1805	CDD:238020
		FN3	1837..1916	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2039..2067
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2098..2172
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:Q6V4S5	2166..2172
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3510
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810