DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DIP-iota and PECAM1

DIOPT Version :9

Sequence 1:	NP_001097100.1	Gene:	DIP-iota / 33925	FlyBaseID:	FBgn0031837	Length:	376	Species:	Drosophila melanogaster
Sequence 2:	NP_000433.4	Gene:	PECAM1 / 5175	HGNCID:	8823	Length:	738	Species:	Homo sapiens

Alignment Length:	376	Identity:	78/376 - (20%)
Similarity:	145/376 - (38%)	Gaps:	93/376 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SQASFSELNNSDPKFSGPINNSTVPVGRDALLTCVVHDLVSFKVAWLRVDTQTILSIQNHVITKN 83
            |:::.|||......||.|..:.: |.|. .:....:|...:.:|..|..:...|:..::..|..:
Human   219 SESTKSELVTVTESFSTPKFHIS-PTGM-IMEGAQLHIKCTIQVTHLAQEFPEIIIQKDKAIVAH 281

  Fly    84 HRISISHTEHRIWQLKIRDVQESDRGWYMCQINTDPMKSQMGYLDVVV--------PPDIVDYQT 140
            :|    |....::.: :..|:.|  |.|.|::.:    |::..:..:|        .|::....|
Human   282 NR----HGNKAVYSV-MAMVEHS--GNYTCKVES----SRISKVSSIVVNITELFSKPELESSFT 335

  Fly   141 SQDVVRSTGQNVTLTCSATGVPMPTITWRREEATPILISDDGDREVFSVEGQNLTLWQVQRSHMG 205
            ..|    .|:.:.|:||..|.|....|.::|:.   ::|...|....:           .:|..|
Human   336 HLD----QGERLNLSCSIPGAPPANFTIQKEDT---IVSQTQDFTKIA-----------SKSDSG 382

  Fly   206 AYLCIASNGVPPTVSK--RVMLVV---NFAPTIWTRYDTIY-VGLGQKLTLEC--ITESQPASVN 262
            .|:|.|  |:...|.|  .|.:||   ...|.|  .||..: |..||.:.:.|  |:.:.|.|..
Human   383 TYICTA--GIDKVVKKSNTVQIVVCEMLSQPRI--SYDAQFEVIKGQTIEVRCESISGTLPISYQ 443

  Fly   263 FWLRDSQLLQGGS------------------YESVS---------VDHVFRI-----VMRITLRP 295
            . |:.|::|:..:                  |:.|:         :..|.|:     |..:.:..
Human   444 L-LKTSKVLENSTKNSNDPAVFKDNPTEDVEYQCVADNCHSHAKMLSEVLRVKVIAPVDEVQISI 507

  Fly   296 ITKR--DFGEYI---CRAKNAMGQTDRIITVHHKAKKHGQHSHQTSSRESQ 341
            ::.:  :.||.|   |......|.    ||.....:|.|:..:|.:|..:|
Human   508 LSSKVVESGEDIVLQCAVNEGSGP----ITYKFYREKEGKPFYQMTSNATQ 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DIP-iota	NP_001097100.1	IG_like	39..125	CDD:214653	15/85 (18%)
		Ig	39..122	CDD:299845	14/82 (17%)
		Ig	132..213	CDD:299845	18/80 (23%)
		IG_like	141..227	CDD:214653	20/87 (23%)
		IG_like	239..322	CDD:214653	22/122 (18%)
		IGc2	245..313	CDD:197706	18/106 (17%)
PECAM1	NP_000433.4	IG_like	43..127	CDD:214653
		Ig_2	327..404	CDD:316418	22/96 (23%)
		IG_like	509..583	CDD:214653	12/50 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	658..715
		ITIM motif 1. /evidence=ECO:0000305\|PubMed:27958302	688..693
		Membrane-bound segment which detaches upon phosphorylation. /evidence=ECO:0000269\|PubMed:21464369	709..729
		ITIM motif 2. /evidence=ECO:0000305\|PubMed:27958302	711..716
		May play a role in cytoprotective signaling	721..738
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000